公开(公告)号：EP2601217A2

公开(公告)日：2013-06-12

申请号：EP11815158.8

申请日：2011-08-02

申请人： AnaptysBio, Inc.

发明人： HORLICK, Robert ,  KING, David ,  BOWERS, Peter ,  DALTON, Jennifer ,  WU, Betty ,  ROBERTS, Traci ,  ZHANG, Xue ,  ALTOBELL III, Laurence

IPC分类号： C07K16/00 ,  A61K39/395 ,  C12N15/00 ,  C12N5/16 ,  C12P21/06

CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/76 ,  C07K2317/92

摘要： The disclosure relates to an isolated IL-17-binding agent which comprises an immunoglobulin heavy chain polypeptide comprising SEQ ID NO: 1 and optionally an immunoglobulin light chain polypeptide comprising SEQ ID NO: 23, except that one or more specific of residues of SEQ ID NO: 1 and SEQ ID NO: 23 are replaced with a different residue. The disclosure also provides vectors, compositions, and methods of using the IL-17-binding agent to treat an IL-17-mediated disease.

公开(公告)号：EP2601217B1

公开(公告)日：2017-06-14

申请号：EP11815158.8

申请日：2011-08-02

申请人： AnaptysBio, Inc.

发明人： HORLICK, Robert ,  KING, David ,  BOWERS, Peter ,  DALTON, Jennifer ,  WU, Betty ,  ROBERTS, Traci ,  ZHANG, Xue ,  ALTOBELL III, Laurence

IPC分类号： C07K16/00 ,  A61K39/395 ,  C12N15/00 ,  C12N5/16 ,  C12P21/06

CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/76 ,  C07K2317/92