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公开(公告)号：EP2601217A2
公开(公告)日：2013-06-12
申请号：EP11815158.8
申请日：2011-08-02
申请人： AnaptysBio, Inc.
发明人： HORLICK, Robert , KING, David , BOWERS, Peter , DALTON, Jennifer , WU, Betty , ROBERTS, Traci , ZHANG, Xue , ALTOBELL III, Laurence
IPC分类号： C07K16/00 , A61K39/395 , C12N15/00 , C12N5/16 , C12P21/06
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/76 , C07K2317/92
摘要： The disclosure relates to an isolated IL-17-binding agent which comprises an immunoglobulin heavy chain polypeptide comprising SEQ ID NO: 1 and optionally an immunoglobulin light chain polypeptide comprising SEQ ID NO: 23, except that one or more specific of residues of SEQ ID NO: 1 and SEQ ID NO: 23 are replaced with a different residue. The disclosure also provides vectors, compositions, and methods of using the IL-17-binding agent to treat an IL-17-mediated disease.
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2.发明公开METHODS OF GENERATING IMPROVED ANTIGEN-BINDING AGENTS USING CHAIN SHUFFLING AND OPTIONALLY SOMATIC HYPERMUTATION 审中-公开用于生产改善的抗原结合剂和手段KETTENUMORDNUNG可选的体细胞突变
公开(公告)号：EP2496706A1
公开(公告)日：2012-09-12
申请号：EP10829021.4
申请日：2010-11-03
申请人： AnaptysBio, Inc.
发明人： HORLICK, Robert
CPC分类号： C12N15/102 , C12N15/1034 , C40B40/08 , C40B50/06
摘要： The invention relates to a method of identifying a desired antigen-binding agent that binds to an antigen of interest. The method utilizes a combinatorial approach wherein a nucleic acid sequence encoding a polypeptide comprising a first component of an antigen-binding agent is provided to a population of cells together with a library of nucleic acid sequences, each of which encodes a polypeptide comprising a second component of an antigen-binding agent. The method further comprises subjecting one or more of the nucleic acid sequences encoding a first component, a second component, and/or an identified antigen-binding agent to somatic hypermutation.
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公开(公告)号：EP2601217B1
公开(公告)日：2017-06-14
申请号：EP11815158.8
申请日：2011-08-02
申请人： AnaptysBio, Inc.
发明人： HORLICK, Robert , KING, David , BOWERS, Peter , DALTON, Jennifer , WU, Betty , ROBERTS, Traci , ZHANG, Xue , ALTOBELL III, Laurence
IPC分类号： C07K16/00 , A61K39/395 , C12N15/00 , C12N5/16 , C12P21/06
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/21 , C07K2317/76 , C07K2317/92
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4.发明公开
公开(公告)号：EP2547781A1
公开(公告)日：2013-01-23
申请号：EP11756860.0
申请日：2011-03-15
申请人： AnaptysBio, Inc.
发明人： HORLICK, Robert , MACOMBER, John , CUBITT, Andrew , KING, David
CPC分类号： C12P21/02 , C07K16/00 , C07K16/244 , C07K2317/34 , C12N15/111 , C12N15/63 , C12N2310/14 , C12N2330/00
摘要： The invention is directed to a method of preparing a nucleic acid sequence with a modified splice site usage profile, which employs the use of a nucleic acid sequence comprising a cryptic splice donor site. The invention also provides a method of producing an alternate form of an RNA molecule encoded by a nucleic acid sequence, which nucleic acid sequence comprises a cryptic splice donor site, a heterologous nucleic acid sequence, and a splice acceptor site.
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