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1.发明公开
公开(公告)号：EP1888739A2
公开(公告)日：2008-02-20
申请号：EP06771115.0
申请日：2006-05-24
申请人： Angros, Lee H. , Byers, Thomas L.
发明人： Angros, Lee H. , Byers, Thomas L.
IPC分类号： C12M3/00
CPC分类号： G01N1/30 , A61F7/0085 , A61F7/12 , A61F2007/0063 , A61F2007/126 , B01L7/00 , B01L7/52 , B01L2200/16 , B01L2300/0822 , B01L2300/14 , B01L2400/0478 , G01N1/28 , G01N1/312 , G01N1/44 , G01N35/00029 , G01N35/026 , G01N2035/00138 , G01N2035/0412 , Y10T436/25
摘要： Contemplated herein is an automated microscope slide antigen recovery and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments for individually and independently processing a plurality of individual microscope slides. The apparatus preferably features independently movable slide support elements each having an individually heatable heating plate. Each slide support element preferably supports a single microscope slide. Each microscope slide can be enclosed within an individual pressurizable reaction compartment. Pressures exceeding 1 atm or below 1 atm can be created and maintained in the reaction compartment prior to, during or after heating of the slide begins. Because of the ability to pressurize and regulate pressure within the reaction compartment, and to individually heat each slide, each slide and a liquid solution or reagent thereon can be heated to temperatures that could not be obtained without the enclosed pressurized environment of the reaction compartment. A reagent dispensing strip having a plurality of reconfigurable reagent modules may also be used.
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公开(公告)号：EP1208378B1
公开(公告)日：2014-03-05
申请号：EP00947135.0
申请日：2000-07-07
申请人： Angros, Lee H.
发明人： Angros, Lee H.
CPC分类号： G01N1/30 , B01L9/52 , G01N1/312 , G01N1/44 , G01N33/52 , G01N33/521 , G01N33/53 , G01N33/5306 , G01N35/00029 , G01N35/00584 , G01N2035/00138 , G01N2035/00346 , Y10T436/11 , Y10T436/110833 , Y10T436/111666 , Y10T436/112499 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
摘要： An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. The reaction conditions for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide.
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3.发明公开
公开(公告)号：EP2969968A1
公开(公告)日：2016-01-20
申请号：EP14764755.6
申请日：2014-03-17
申请人： Angros, Lee H.
发明人： Angros, Lee H.
IPC分类号： C02F1/40
摘要： A method of removing a floatation liquid from between a microscope slide and a paraffin embedded biological specimen including position the microscope slide with the paraffin embedded biological specimen floated thereon onto a slide support element. The slide support element is rotated to cause the microscope slide and the paraffin embedded biological specimen to turn in a way that causes the floatation liquid disposed between the microscope slide and the paraffin embedded biological specimen to be drawn from between the microscope slide and the paraffin embedded biological specimen.
摘要翻译： 一种从显微镜载玻片和石蜡包埋的生物样品之间除去漂浮液的方法，包括将显微镜载玻片与石蜡包埋的生物样品置于载玻片支撑元件上。 旋转滑动支撑元件以使显微镜载玻片和石蜡包埋的生物样本移动，使得布置在显微镜载玻片和石蜡包埋的生物样本之间的浮选液体从显微镜载玻片和石蜡包埋之间移除 生物标本。
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公开(公告)号：EP1055123B1
公开(公告)日：2007-08-08
申请号：EP99905927.2
申请日：1999-02-09
申请人： Angros, Lee H.
发明人： Angros, Lee H.
CPC分类号： B01L3/508 , B01L2300/0822 , G02B21/34
摘要： An analytical plate such as a microscope slide (10) having an upper surface (12) and a lower surface (14). Disposed upon a portion of the upper surface (12) is a liquid containment border (16).
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公开(公告)号：EP2062045A2
公开(公告)日：2009-05-27
申请号：EP07837343.8
申请日：2007-08-25
申请人： Angros, Lee H.
发明人： Angros, Lee H.
CPC分类号： G01N1/30 , B01L3/5082 , B01L3/545 , B01L3/5453 , B01L2300/0822 , C09D5/32
摘要： An analytical plate or other substrate (12) having a permanent etchable, laserable, an/or developable marking surface coating (22) that is present on at least a portion of any side or surface thereof and is used to form a permanent indicium thereon.
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公开(公告)号：EP1991900A2
公开(公告)日：2008-11-19
申请号：EP06826510.7
申请日：2006-10-24
申请人： Angros, Lee H.
发明人： Angros, Lee H.
IPC分类号： G02B21/34
CPC分类号： G02B21/34
摘要： The present invention is a microscope coverslip constructed of a glass or plastic plate having an indicium thereon which can be used to uniquely or non-uniquely identify the coverslip or the microscope slide to which the coverslip is attached and/or provide information therefor. Preferably the indicium, such as a barcode, is machine readable. The microscope coverslip may have an adherent surface and a non-adherent surface, the adherent surface having a solvent activated dry adhesive film (adhesive coating) bonded thereto and having an indicium thereon for indicating the adherent side of the coverslip. The dry adhesive film of the adherent surface is non-tacky (non-sticky) in its storage or preapplication condition. At use, the adhesive of the adherent side can be activated by a solvent.
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公开(公告)号：EP1055123A1
公开(公告)日：2000-11-29
申请号：EP99905927.2
申请日：1999-02-09
申请人： Angros, Lee H.
发明人： Angros, Lee H.
IPC分类号： G01N33/48
CPC分类号： B01L3/508 , B01L2300/0822 , G02B21/34
摘要： An analytical plate such as a microscope slide (10) having an upper surface (12) and a lower surface (14). Disposed upon a portion of the upper surface (12) is a liquid containment border (16).
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公开(公告)号：EP1874485B1
公开(公告)日：2018-11-07
申请号：EP06750302.9
申请日：2006-04-14
申请人： Angros, Lee H.
发明人： Angros, Lee H.
IPC分类号： B01L3/02 , B05C9/06 , B05C9/14 , B05D7/00 , B05D1/02 , B05D1/20 , B05D1/28 , G01N1/30 , B01L99/00 , B05C13/02 , B01L3/00 , B05C1/02 , B05C11/02
CPC分类号： G01N1/30 , B01L3/0258 , B01L3/508 , B01L99/00 , B01L2200/12 , B01L2300/0822 , B01L2300/16 , B01L2300/161 , B05C1/025 , B05C9/06 , B05C9/14 , B05C11/028 , B05C13/02 , B05D1/02 , B05D1/20 , B05D1/28 , B05D7/5483 , B05D2252/04 , G01N2001/305 , Y10T156/179 , Y10T156/1798
摘要： An apparatus and method for producing a coated analytic substrate using a compact and portable automated instrument located in the laboratory setting at the point of use which can consistently produce one or a plurality of coated analytic substrates “on demand” for using the analytic substrate immediately after coating, preferably without a step of rinsing the coated analytic substrate before use. The apparatus preferably uses applicator cartridges having a reservoir containing the coating compositions used to form the coatings. Preferably the cartridges are removable and interchangeable to facilitate the production of individual analytic substrates having different coatings or different coating patterns. These coated analytic substrates have superior specimen adhesion characteristics due to the improved quality of the coatings applied by the coating apparatus and due to the quickness with which the coated analytic substrates can be used in the lab after production.
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公开(公告)号：EP1208378B9
公开(公告)日：2014-12-10
申请号：EP00947135.0
申请日：2000-07-07
申请人： Angros, Lee H.
发明人： Angros, Lee H.
CPC分类号： G01N1/30 , B01L9/52 , G01N1/312 , G01N1/44 , G01N33/52 , G01N33/521 , G01N33/53 , G01N33/5306 , G01N35/00029 , G01N35/00584 , G01N2035/00138 , G01N2035/00346 , Y10T436/11 , Y10T436/110833 , Y10T436/111666 , Y10T436/112499 , Y10T436/114165 , Y10T436/114998 , Y10T436/119163 , Y10T436/25 , Y10T436/2575
摘要： An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do not need to be physically removed from one apparatus to another. The reaction conditions for treating a slide can preferably be controlled independently, including the individualized application of reagents to each slide and the individualized treatment of each slide.
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公开(公告)号：EP1874485A2
公开(公告)日：2008-01-09
申请号：EP06750302.9
申请日：2006-04-14
申请人： Angros, Lee H.
发明人： Angros, Lee H.
IPC分类号： B05D3/02
CPC分类号： G01N1/30 , B01L3/0258 , B01L3/508 , B01L99/00 , B01L2200/12 , B01L2300/0822 , B01L2300/16 , B01L2300/161 , B05C1/025 , B05C9/06 , B05C9/14 , B05C11/028 , B05C13/02 , B05D1/02 , B05D1/20 , B05D1/28 , B05D7/5483 , B05D2252/04 , G01N2001/305 , Y10T156/179 , Y10T156/1798
摘要： An apparatus and method for producing a coated analytic substrate using a compact and portable automated instrument located in the laboratory setting at the point of use which can consistently produce one or a plurality of coated analytic substrates “on demand” for using the analytic substrate immediately after coating, preferably without a step of rinsing the coated analytic substrate before use. The apparatus preferably uses applicator cartridges having a reservoir containing the coating compositions used to form the coatings. Preferably the cartridges are removable and interchangeable to facilitate the production of individual analytic substrates having different coatings or different coating patterns. These coated analytic substrates have superior specimen adhesion characteristics due to the improved quality of the coatings applied by the coating apparatus and due to the quickness with which the coated analytic substrates can be used in the lab after production.
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