公开(公告)号：EP1869158A2

公开(公告)日：2007-12-26

申请号：EP06739280.3

申请日：2006-03-21

申请人： Applera Corporation

发明人： CARRILLO, Albert L. ,  FAWCETT, Adrian ,  HARDING, Ian A. ,  LU, Mike Y. ,  OLDHAM, Mark F.

IPC分类号： C12M1/34 ,  C12M3/00

CPC分类号： B01L3/0268 ,  B01L3/5025 ,  B01L3/5027 ,  B01L3/50851 ,  B01L3/50853 ,  B01L7/52 ,  B01L2200/021 ,  B01L2200/0605 ,  B01L2200/0642 ,  B01L2200/0689 ,  B01L2200/142 ,  B01L2300/021 ,  B01L2300/044 ,  B01L2300/0829 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0487 ,  G01N35/04

摘要： In a high-density sequence detection system, an apparatus for transporting a microplate. A control system provides a thermocycler control signal to regulate a desired thermal output of a thermocycler block. A frame has a first side, a second side, and an opening that extends through the first side and the second side. A window is positioned in the opening and a circumferential seal is positioned around a periphery of the opening at the second side. The seal has a peripheral lip that seals against the microplate. A clamp is adapted to engage and displace the frame from an unclamped position to a clamped position, wherein in the unclamped position, the microplate is displaced away from the thermocycler block and in the clamped position, the clamp urges the microplate against the thermocycler block. In some embodiments the peripheral lip is positioned radially inward of the periphery of the opening.

公开(公告)号：EP2046940A2

公开(公告)日：2009-04-15

申请号：EP07809900.9

申请日：2007-06-26

申请人： Applera Corporation

发明人： HIRANO, Kirk M. ,  BABCOKE, Jason E. ,  CARRILLO, Albert L. ,  HAGA, Douwe D. ,  KAO, Pin ,  KINNEY, Patrick D. ,  NURSE, James C.

IPC分类号： C12M1/02

CPC分类号： B01L7/52 ,  B01L3/50851 ,  B01L3/50853 ,  B01L3/50857 ,  B01L7/00 ,  B01L2200/0605 ,  B01L2200/0642 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/1816 ,  B01L2300/1838 ,  B01L2300/1861 ,  B01L2300/1872 ,  F28F13/00 ,  F28F2013/001 ,  G01N21/0332 ,  G01N21/6452 ,  G01N2201/062 ,  H05B3/84 ,  H05B6/02 ,  H05B6/105

摘要： A heating apparatus comprising a support base and a microplate having a first surface and an opposing second surface. The microplate is positioned adjacent the support base and comprises a plurality of wells formed in the first surface thereof. Each of the plurality of wells is sized to receive an assay therein. A sapphire crystalline transparent window is positioned adjacent the microplate opposing the support base. A heating device heats the transparent window in response to a control system.

公开(公告)号：EP2040983A2

公开(公告)日：2009-04-01

申请号：EP07809899.3

申请日：2007-06-26

申请人： Applera Corporation

发明人： HIRANO, Kirk M. ,  NURSE, James C. ,  CARRILLO, Albert L. ,  LU, Mike Y. ,  FAWCETT, Adrian

IPC分类号： B65B7/28

CPC分类号： G01N35/028 ,  B01L3/50851 ,  B01L3/50853 ,  B01L3/563 ,  B01L7/52 ,  B01L2200/0605 ,  B01L2200/0642 ,  B01L2200/142 ,  B01L2300/041 ,  B01L2300/044 ,  B01L2300/046 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/0864 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1872 ,  B01L2400/0406 ,  B01L2400/0487 ,  G01N2035/00287

摘要： An apparatus for sealing a microplate, wherein the apparatus comprises a microplate having a first surface and an opposing second surface. A plurality of wells is formed in the first surface of the microplate, wherein each of the plurality of wells is sized to receive an assay therein. A sealing cover is disposed over the microplate adjacent the plurality of wells and is compliant to accommodate variations between the sealing cover and the microplate and/or distribute loads evenly therebetween.