公开(公告)号：EP3218107A1

公开(公告)日：2017-09-20

申请号：EP15794534.6

申请日：2015-11-10

申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.

发明人： NOLL, Reinhard ,  LENENBACH, Achim ,  MEINEKE, Georg ,  MATHIS, Harald

IPC分类号： B01L3/00 ,  G01N15/10

CPC分类号： G01N15/10 ,  B01L3/502738 ,  B01L3/502761 ,  B01L2200/0652 ,  B01L2300/0864 ,  B01L2300/0883 ,  B01L2300/1861 ,  B01L2300/1872 ,  B01L2400/0442 ,  B01L2400/0622 ,  G01N2015/1081 ,  G01N2015/1415

摘要： The invention relates to a method and a device for sorting microparticles (6) in a fluid flow (5) whereby a microparticle (6) is detected by means of a detection unit and an identification signal is generated when the microparticle (6) passes a detection area (7), and at a switching point (8, 9), which is selected depending on the identification signal, of a branching with at least one inlet (2) and at least two outlets (3, 4), the viscosity of the fluid (5) is decreased by means of irradiation with electromagnetic radiation for a predetermined period of time once a predetermined time span after the generation of the identification signal has elapsed such that the proportion of the portions of the fluid flow (5) passing through the at least two outlets (3, 4) is changed in such a way that the microparticle (6) is guided through the outlet determined by the identification signal.

摘要翻译： 本发明涉及一种用于在流体流动（5）中分选微粒（6）的方法和设备，借此通过检测单元检测微粒（6），并且当微粒（6）通过 （2）和至少两个出口（3,4）分支的切换点（7），并且在根据识别信号选择的切换点（8,9）处，粘度 一旦在识别信号产生之后的预定时间间隔已经过去，流体（5）的一部分通过用电磁辐射照射预定的时间段减少，使得流体流（5）的部分通过 通过至少两个出口（3,4）以这样的方式改变，使得微粒（6）被引导通过由识别信号确定的出口。

公开(公告)号：EP2496924A4

公开(公告)日：2016-03-23

申请号：EP10827750

申请日：2010-11-03

申请人： 7685297 CANADA INC

发明人： KANIPAYOR RAVI K ,  EMBURGH RON J

IPC分类号： G01N1/44 ,  B01L7/00

CPC分类号： G01N1/4044 ,  B01L3/04 ,  B01L7/00 ,  B01L2300/049 ,  B01L2300/0832 ,  B01L2300/1822 ,  B01L2300/1838 ,  B01L2300/1872 ,  B01L2300/1883 ,  B01L2300/1894 ,  G01N1/10 ,  G01N1/4022 ,  G01N1/42 ,  G01N1/44 ,  Y10T436/25 ,  Y10T436/25125

摘要： A system for preparing samples for chemical analysis comprises at least one sample container, and a container receptacle apparatus for receiving the sample container. The sample container comprises an elongate tubular body having a crucible portion proximal to a closed end for receiving a sample therein, and an expansion portion proximal to an open end. The container receptacle apparatus comprising a housing having a heating compartment, a cooling compartment spaced apart from the heating compartment, and an insulating region located between the heating compartment and the cooling compartment. The heating compartment is shaped to receive the crucible portion of the sample container, and the cooling compartment is shaped to receive the expansion portion of the sample container. The apparatus also includes a heating mechanism for heating the sample within the crucible portion of the sample container, and a cooling mechanism for cooling the expansion portion of the sample container.

公开(公告)号：EP2240613B1

公开(公告)日：2013-09-11

申请号：EP09709059.1

申请日：2009-02-06

申请人： Ludwig-Maximilians-Universität München ,  Baaske, Philipp ,  Duhr, Stefan

发明人： DUHR, Stefan ,  BAASKE, Philipp

IPC分类号： C12Q1/68 ,  G01N21/64

CPC分类号： G01N21/6428 ,  B01L3/50273 ,  B01L2300/0822 ,  B01L2300/1861 ,  B01L2300/1872 ,  B01L2400/0451 ,  C12Q1/6813 ,  G01N21/171 ,  G01N21/6408 ,  G01N21/6458 ,  C12Q2527/107 ,  C12Q2523/313

公开(公告)号：EP1567861B1

公开(公告)日：2010-04-28

申请号：EP03773337.5

申请日：2003-11-20

申请人： Corbett Life Science Pty Ltd

发明人： CORBETT, John, Michael ,  CORBETT, John, Michael, Jr

IPC分类号： G01N33/543 ,  G01N33/00 ,  B01L7/00 ,  C12Q1/68

CPC分类号： G01N21/6428 ,  B01L3/502 ,  B01L3/50851 ,  B01L7/52 ,  B01L2300/0636 ,  B01L2300/0803 ,  B01L2300/1844 ,  B01L2300/1872 ,  B01L2400/0409 ,  G01N33/54366

摘要： The invention the subject of this application relates to a device performing binding assays. In particular, the invention relates to a centrifugal device (1) for performing such assays. The invention also relates to a method of performing binding assays involving antigen-antibody binding, nucleic acid hybridization, or receptor-ligand interaction.

公开(公告)号：EP2046940A2

公开(公告)日：2009-04-15

申请号：EP07809900.9

申请日：2007-06-26

申请人： Applera Corporation

发明人： HIRANO, Kirk M. ,  BABCOKE, Jason E. ,  CARRILLO, Albert L. ,  HAGA, Douwe D. ,  KAO, Pin ,  KINNEY, Patrick D. ,  NURSE, James C.

IPC分类号： C12M1/02

CPC分类号： B01L7/52 ,  B01L3/50851 ,  B01L3/50853 ,  B01L3/50857 ,  B01L7/00 ,  B01L2200/0605 ,  B01L2200/0642 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/1816 ,  B01L2300/1838 ,  B01L2300/1861 ,  B01L2300/1872 ,  F28F13/00 ,  F28F2013/001 ,  G01N21/0332 ,  G01N21/6452 ,  G01N2201/062 ,  H05B3/84 ,  H05B6/02 ,  H05B6/105

摘要： A heating apparatus comprising a support base and a microplate having a first surface and an opposing second surface. The microplate is positioned adjacent the support base and comprises a plurality of wells formed in the first surface thereof. Each of the plurality of wells is sized to receive an assay therein. A sapphire crystalline transparent window is positioned adjacent the microplate opposing the support base. A heating device heats the transparent window in response to a control system.

公开(公告)号：EP2040983A2

公开(公告)日：2009-04-01

申请号：EP07809899.3

申请日：2007-06-26

申请人： Applera Corporation

发明人： HIRANO, Kirk M. ,  NURSE, James C. ,  CARRILLO, Albert L. ,  LU, Mike Y. ,  FAWCETT, Adrian

IPC分类号： B65B7/28

CPC分类号： G01N35/028 ,  B01L3/50851 ,  B01L3/50853 ,  B01L3/563 ,  B01L7/52 ,  B01L2200/0605 ,  B01L2200/0642 ,  B01L2200/142 ,  B01L2300/041 ,  B01L2300/044 ,  B01L2300/046 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/0864 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1872 ,  B01L2400/0406 ,  B01L2400/0487 ,  G01N2035/00287

摘要： An apparatus for sealing a microplate, wherein the apparatus comprises a microplate having a first surface and an opposing second surface. A plurality of wells is formed in the first surface of the microplate, wherein each of the plurality of wells is sized to receive an assay therein. A sealing cover is disposed over the microplate adjacent the plurality of wells and is compliant to accommodate variations between the sealing cover and the microplate and/or distribute loads evenly therebetween.

公开(公告)号：EP1567861A4

公开(公告)日：2008-04-09

申请号：EP03773337

申请日：2003-11-20

申请人： CORBETT LIFE SCIENCE PTY LTD

发明人： CORBETT JOHN MICHAEL ,  CORBETT JOHN MICHAEL JR

IPC分类号： B01L3/00 ,  B01L7/00 ,  G01N33/543 ,  C12Q1/68 ,  G01N33/00

CPC分类号： G01N21/6428 ,  B01L3/502 ,  B01L3/50851 ,  B01L7/52 ,  B01L2300/0636 ,  B01L2300/0803 ,  B01L2300/1844 ,  B01L2300/1872 ,  B01L2400/0409 ,  G01N33/54366

摘要： The invention the subject of this application relates to a device performing binding assays. In particular, the invention relates to a centrifugal device (1) for performing such assays. The invention also relates to a method of performing binding assays involving antigen-antibody binding, nucleic acid hybridization, or receptor-ligand interaction.

公开(公告)号：EP1885885A2

公开(公告)日：2008-02-13

申请号：EP06759494.5

申请日：2006-05-10

申请人： Nanolytics, Inc.

发明人： SHENDEROV, Alexander D.

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： B01L7/525 ,  B01L3/502792 ,  B01L2200/0673 ,  B01L2300/0654 ,  B01L2300/0864 ,  B01L2300/0887 ,  B01L2300/089 ,  B01L2300/1816 ,  B01L2300/1827 ,  B01L2300/1872 ,  B01L2400/0427

摘要： Methods and devices for conducting chemical or biochemical reactions that require multiple reaction temperatures are described. The methods involve moving one or more reaction droplets or reaction volumes through various reaction zones having different temperatures on a microfluidics apparatus. The devices comprise a microfluidics apparatus comprising appropriate actuators capable of moving reaction droplets or reaction volumes through the various reaction zones.

摘要翻译： 方法和装置用于进行化学或生物化学反应那样需要多个反应温度进行说明。 该方法涉及将一个或多个反应液滴或反应体积通过各种反应区上的微流体装置，其具有不同的温度。 该装置包括微流体装置，其包括能够通过各个反应区移动反应液滴或反应体积的适当的致动器。

公开(公告)号：EP1534954A1

公开(公告)日：2005-06-01

申请号：EP03787745.3

申请日：2003-08-14

申请人： Memsflow APS

发明人： USSING, Tomas

IPC分类号： F04B19/24

CPC分类号： B01F13/0079 ,  B01B1/005 ,  B01F5/0471 ,  B01F13/0001 ,  B01F13/0008 ,  B01F13/0064 ,  B01F13/0094 ,  B01F2215/0431 ,  B01F2215/0477 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00934 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L3/502776 ,  B01L7/52 ,  B01L2200/147 ,  B01L2300/168 ,  B01L2300/1861 ,  B01L2300/1872 ,  B01L2400/0442 ,  F04B17/00 ,  F04B19/006 ,  F04B19/24 ,  F16K99/0001 ,  F16K99/0019 ,  F16K99/0036 ,  F16K2099/0084 ,  F16K2099/0094

摘要： The invention makes available methods and devices for handling liquids in micro channel systems by means of bubbles generated by a movable light beam. In particular the devices relate to pumps, valves, mixers and thermal reactors in micro channel systems and the combination of these devices into larger systems. The methods relate the preparation and operation of the devices.

公开(公告)号：EP0943011A4

公开(公告)日：2004-03-31

申请号：EP97938302

申请日：1997-08-14

申请人： AMERSHAM BIOSCIENCES CORP

发明人： FRANCISKOVICH PHILLIP P

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： B01L7/52 ,  B01L2200/0647 ,  B01L2300/1861 ,  B01L2300/1872

摘要： A method and device for promoting induced thermal transduction in chemical and biochemical reactions is disclosed. In one preferred embodiment, a method of elongating a primer annealed to a DNA template is disclosed. This method comprises the first step of combining a radio frequency responsive support in an aqueous environment with a DNA template molecule, DNA primers, DNA polymerase, deoxynucleotide triphosphates and reagents necessary to amplify the DNA template. An electromagnetic field is then applied to the combination, wherein the temperature of the support will increase and the DNA template with become denatured. The electromagnetic field is removed and the temperature of the support decreases. The primer molecules anneal to the denatured DNA template and the DAN polymerase catalyzes elongation of the primer. In an especially preferred embodiment of the present invention, the support is derivatized so that the DNA template molecules are attracted to the surface of the support. The figure diagrams the relationship between PCR reagents, including the DNA template, primers and DNA polymerase, and the radio frequency responsive support.