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1.发明授权
公开(公告)号：EP2250155B1
公开(公告)日：2013-07-03
申请号：EP09701043.3
申请日：2009-01-09
发明人： BANKA, Anna , BENCSIK, Josef R. , BLAKE, James F. , HENTEMANN, Martin F. , KALLAN, Nicholas C. , LIANG, Jun , MITCHELL, Ian S. , SCHLACHTER, Stephen T. , WALLACE, Eli M. , XU, Rui , TANG, Tony, P.
IPC分类号： C07D239/70 , A61K31/517 , A61P35/00 , C07D401/04 , C07D401/10 , C07D409/04 , C07D417/04 , C07D487/04
CPC分类号： C07D401/10 , C07D211/08 , C07D211/46 , C07D239/70 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/10 , C07D409/04 , C07D417/04 , C07D417/10 , C07D487/04
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2.发明公开
公开(公告)号：EP2250155A1
公开(公告)日：2010-11-17
申请号：EP09701043.3
申请日：2009-01-09
发明人： BANKA, Anna , BENCSIK, Josef R. , BLAKE, James F. , HENTEMANN, Martin F. , KALLAN, Nicholas C. , LIANG, Jun , MITCHELL, Ian S. , SCHLACHTER, Stephen T. , WALLACE, Eli M. , XU, Rui , TANG, Tony, P.
IPC分类号： C07D239/70 , A61K31/517 , A61P35/00 , C07D401/04 , C07D401/10 , C07D409/04 , C07D417/04 , C07D487/04
CPC分类号： C07D401/10 , C07D211/08 , C07D211/46 , C07D239/70 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/10 , C07D409/04 , C07D417/04 , C07D417/10 , C07D487/04
摘要： Compounds of Formula I are useful for inhibiting AKT protein kinases. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. Formula (I).
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公开(公告)号：EP2766368A1
公开(公告)日：2014-08-20
申请号：EP12775905.8
申请日：2012-10-09
申请人： Array Biopharma Inc.
发明人： BOYS, Mark Laurence , BURGESS, Laurence E. , EARY, C. Todd , GRONEBERG, Robert , HACHE, Bruno P. , HARVEY, Darren , HICKEN, Erik James , KRASER, Christopher F. , LAIRD, Ellen , MORENO, David A. , MUNSON, Mark C. , REN, Li , ROBINSON, John E. , SCHLACHTER, Stephen T.
IPC分类号： C07D487/04 , A61K31/519 , A61P29/00 , A61P37/00
CPC分类号： C07D487/04
摘要： Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , X
1 and X
2 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.摘要翻译： 其中R 1，R 2，R 3，R 4，R 5，R 6，X 1和X 2具有说明书中给出的含义的式I化合物及其立体异构体和药学上可接受的盐和溶剂合物是 一种或多种JAK激酶，并且可用于治疗自身免疫性疾病，炎性疾病，移植器官，组织和细胞的排斥，以及血液病和恶性肿瘤及其并发症。
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公开(公告)号：EP2334677B1
公开(公告)日：2013-10-09
申请号：EP09791625.8
申请日：2009-08-18
发明人： ALLEN, Shelley , CELESTE, Laura L. , DAVIS, T. Gregg , DELISLE, Robert Kirk , GRESCHUK, Julie Marie , GROSS, Stefan, D. , HICKEN, Erik, James , JACKSON, Leila, J. , LYSSIKATOS, Joseph, P. , KALLAN, Nicholas C. , MARMSATER, Fredrik, P. , MUNSON, Mark, C. , PHENEGER, Jed , RAST, Bryson , ROBINSON, John, E. , SCHLACHTER, Stephen T. , TOPALOV, George T. , WRIGHT, A. Dale , ZHAO, Qian
IPC分类号： C07D471/04 , A61K31/47
CPC分类号： C07D471/04
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公开(公告)号：EP2334677A1
公开(公告)日：2011-06-22
申请号：EP09791625.8
申请日：2009-08-18
发明人： ALLEN, Shelley , CELESTE, Laura L. , DAVIS, T. Gregg , DELISLE, Robert Kirk , GRESCHUK, Julie Marie , GROSS, Stefan, D. , HICKEN, Erik, James , JACKSON, Leila, J. , LYSSIKATOS, Joseph, P. , KALLAN, Nicholas C. , MARMSATER, Fredrik, P. , MUNSON, Mark, C. , PHENEGER, Jed , RAST, Bryson , ROBINSON, John, E. , SCHLACHTER, Stephen T. , TOPALOV, George T. , WRIGHT, A. Dale , ZHAO, Qian
IPC分类号： C07D471/04 , A61K31/47
CPC分类号： C07D471/04
摘要： Compounds of Formula (I), in which A, B, R
1 , R
1a , R
2 , R
3 , R
4 , R
5 , R
6 , and R
7 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of immune cell-associated diseases and disorders, such as inflammatory and autoimmune diseases.摘要翻译： 其中A，B，R 1，R 1a，R 2，R 3，R 4，R 5，R 6和R 7具有说明书中给出的含义的式（I）化合物是有用的受体酪氨酸抑制剂 用于治疗免疫细胞相关疾病和病症，例如炎性和自身免疫性疾病。
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