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公开(公告)号：EP3738611A1
公开(公告)日：2020-11-18
申请号：EP20180951.4
申请日：2014-07-30
申请人： BioNTech AG , Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , WALTER, Korden , WAGNER, Meike , KREUZBERG, Maria , HÄCKER, Sabine , JACOBS, Stefan
IPC分类号： A61K39/395 , G01N33/50 , G01N33/569 , G01N33/574
摘要： The present invention provides methods for diagnosis or treatment of cancer diseases involving cancer stem cells comprising targeting CLDN6. In particular, the present invention provides a method of determining cancer stem cells comprising detecting cells expressing CLDN6. Furthermore, the present invention provides a method of treating or preventing cancer comprising inhibiting and/or eliminating cancer stem cells by administering an antibody having the ability of binding to CLDN6 to a cancer patient.
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公开(公告)号：EP3738612A1
公开(公告)日：2020-11-18
申请号：EP20181374.8
申请日：2014-07-30
申请人： Biontech AG , Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , WALTER, Korden , WAGNER, Meike , KREUZBERG, Maria , HÄCKER, Sabine , JACOBS, Stefan
IPC分类号： A61K39/395 , G01N33/50 , G01N33/569 , G01N33/574
摘要： The present invention provides methods for diagnosis or treatment of cancer diseases involving cancer stem cells comprising targeting CLDN6. In particular, the present invention provides a method of determining cancer stem cells comprising detecting cells expressing CLDN6. Furthermore, the present invention provides a method of treating or preventing cancer comprising inhibiting and/or eliminating cancer stem cells by administering an antibody having the ability of binding to CLDN6 to a cancer patient.
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公开(公告)号：EP3027208B1
公开(公告)日：2020-06-24
申请号：EP14750331.2
申请日：2014-07-30
申请人： Biontech AG , Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , WALTER, Korden , WAGNER, Meike , KREUZBERG, Maria , HÄCKER, Sabine , JACOBS, Stefan
IPC分类号： A61K39/395 , G01N33/50
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公开(公告)号：EP2591003B1
公开(公告)日：2020-05-13
申请号：EP11730907.0
申请日：2011-07-04
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , WALTER, Korden , KREUZBERG, Maria , LUXEN, Sylvia
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
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公开(公告)号：EP4331578A3
公开(公告)日：2024-06-05
申请号：EP23209136.3
申请日：2016-04-13
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , WALTER, Korden , KREUZBERG, Maria , MITNACHT-KRAUS, Rita , LE GALL, Fabrice , JACOBS, Stefan
CPC分类号： C07K16/28 , C07K16/303 , C07K16/3046 , A61K2039/50520130101 , A61K2039/62720130101 , C07K2317/2420130101 , C07K2317/7720130101 , A61K47/6849 , A61K47/6863 , A61K47/6859 , A61P35/04 , A61P35/00 , A61K31/40 , A61K47/68031 , A61K47/68033
摘要： The present invention provides anti-CLDN18.2 antibody-drug conjugates which are effective for treating and/or preventing cancer diseases associated with cells expressing CLDN18.2, including gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.
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公开(公告)号：EP4461354A2
公开(公告)日：2024-11-13
申请号：EP24193389.4
申请日：2010-11-11
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , WALTER, Korden , WÖLL, Stefan , KREUZBERG, Maria , HUBNER, Bernd , ERDELJAN, Michael
IPC分类号： A61P1/18
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing Claudin-6 (CLDN6), including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.
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公开(公告)号：EP4331578A2
公开(公告)日：2024-03-06
申请号：EP23209136.3
申请日：2016-04-13
申请人： Astellas Pharma Inc. , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , WALTER, Korden , KREUZBERG, Maria , MITNACHT-KRAUS, Rita , LE GALL, Fabrice , JACOBS, Stefan
IPC分类号： A61K31/40
摘要： The present invention provides anti-CLDN18.2 antibody-drug conjugates which are effective for treating and/or preventing cancer diseases associated with cells expressing CLDN18.2, including gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.
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公开(公告)号：EP3027208A1
公开(公告)日：2016-06-08
申请号：EP14750331.2
申请日：2014-07-30
申请人： Biontech AG , GANYMED Pharmaceuticals AG , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , WALTER, Korden , WAGNER, Meike , KREUZBERG, Maria , HÄCKER, Sabine , JACOBS, Stefan
IPC分类号： A61K39/395 , A61K47/48 , G01N33/50 , G01N33/569 , G01N33/574
摘要： The present invention provides methods for diagnosis or treatment of cancer diseases involving cancer stem cells comprising targeting CLDN6. In particular, the present invention provides a method of determining cancer stem cells comprising detecting cells expressing CLDN6, Furthermore, the present invention provides a method of treating or preventing cancer comprising inhibiting and/or eliminating cancer stem cells by administering an antibody having the ability of binding to CLDN6 to a cancer patient.
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公开(公告)号：EP3283521A1
公开(公告)日：2018-02-21
申请号：EP16715583.7
申请日：2016-04-13
申请人： Ganymed Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , WALTER, Korden , KREUZBERG, Maria , MITNACHT-KRAUS, Rita , LE GALL, Fabrice , JACOBS, Stefan
CPC分类号： A61K47/6859 , A61K31/40 , A61K47/6803 , A61K47/6849 , A61K47/6863 , A61K2039/505 , A61K2039/627 , A61P35/00 , A61P35/04 , C07K16/28 , C07K16/303 , C07K16/3046 , C07K2317/24 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要： The present invention provides anti-CLDN18.2 antibody-drug conjugates which are effective for treating and/or preventing cancer diseases associated with cells expressing CLDN18.2, including gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.
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公开(公告)号：EP3026064B1
公开(公告)日：2018-10-17
申请号：EP15201110.2
申请日：2012-04-20
申请人： Ganymed Pharmaceuticals GmbH , TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg- Universität Mainz gemeinnützige GmbH
发明人： SAHIN, Ugur , TÜRECI, Özlem , KOSLOWSKI, Michael , WALTER, Korden , WÖLL, Stefan , KREUZBERG, Maria , HUBNER, Bernd , ERDELJAN, Michael , WEICHEL, Michael
IPC分类号： C07K16/30 , A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： C07K16/30 , A61K39/39591 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLDN6, including tumor- related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.
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