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    SPIROIMIDAZOLE COMPOUNDS AND THEIR USE AS BACE INHIBITORS
    2.
    发明公开
    SPIROIMIDAZOLE COMPOUNDS AND THEIR USE AS BACE INHIBITORS 审中-公开
    螺咪唑化合物及其作为BACE抑制剂的用途

    公开(公告)号：EP3176172A1

    公开(公告)日：2017-06-07

    申请号：EP17150757.7

    申请日：2011-12-21

    申请人： Astrazeneca AB

    发明人： CSJERNYIK, Gabor ,  KARLSTR M, Sofia ,  KERS, Annika ,  KOLMODIN, Karin ,  NYLÖF, Martin ,  ÖHBERG, Liselotte ,  RAKOS, Laszlo ,  SANDBERG, Lars ,  SEHGELMEBLE, Fernando ,  SÖDERMAN, Peter ,  SWAHN, Britt-Marie ,  VON BERG, Stefan

    IPC分类号： C07D491/107 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/4439 ,  A61K31/506 ,  A61P25/28 ,  C07D401/04 ,  C07D235/02 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D491/20

    摘要： The present invention relates to compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of Aß-related pathologies such as Down's syndrome, ß- amyloid angiopathy such as, but not limited to, cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI ("mild cognitive impairment"), Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease.

    摘要翻译： 本发明涉及式（I）的化合物及其药物组合物。 此外，本发明涉及用于治疗和/或预防Aβ相关病症如唐氏综合症，β-淀粉样血管病例如但不限于脑淀粉样血管病或遗传性脑出血的疾病的治疗方法，与 认知障碍，诸如但不限于MCI（“轻度认知障碍”），阿尔茨海默病，记忆丧失，与阿尔茨海默病相关的注意力缺陷症状，与诸如阿尔茨海默病的疾病相关的神经变性或包括混合血管和退行性起源的痴呆在内的痴呆， 老年痴呆症，老年痴呆症和帕金森病相关的痴呆症。