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公开(公告)号：EP2367814A1
公开(公告)日：2011-09-28
申请号：EP09826375.9
申请日：2009-11-13
申请人： AstraZeneca AB
发明人： HOLENZ, Jörg , KARLSTRÖM, Sofia , KOLMODIN, Karin , LINDSTRÖM, Johan , RAKOS, Laszlo , ROTTICCI, Didier , SÖDERMAN, Peter , SWAHN, Britt-Marie , VON BERG, Stefan
IPC分类号： C07D401/14 , A61K31/4439 , A61K31/444 , A61K31/506 , A61P25/28 , C07D401/04 , C07D403/04 , C07D403/10 , C07D403/14
CPC分类号： C07D401/14 , C07D401/04 , C07D403/04 , C07D403/10
摘要： The present invention relates to novel compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of Aβ-related pathologies such as Downs syndrome, β-amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI ("mild cognitive impairment"), Alzheimer Disease, memory loss, attention deficit symptoms associated with Alzheimer disease, neurodegeneration associated with diseases such as Alzheimer disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.
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2.发明公开AMINO-IMIDAZOLONES AND THEIR USE AS A MEDICAMENT FOR TREATING COGNITIVE IMPAIRMENT, ALZHEIMER DISEASE, NEURODEGENERATION AND DEMENTIA 审中-公开氨基咪唑啉酮及其作为药物治疗认知障碍，阿尔茨海默病，神经退化和痴呆的药物
公开(公告)号：EP2044072A1
公开(公告)日：2009-04-08
申请号：EP07748237.0
申请日：2007-06-12
发明人： BERG, Stefan , HOLENZ, Jörg , HÖGDIN, Katharina , KOLMODIN, Karin , PLOBECK, Niklas , ROTTICCI, Didier , SEHGELMEBLE, Fernando , EK, Maria
IPC分类号： C07D487/04 , A61K31/519 , A61P25/28
CPC分类号： C07D487/04
摘要： This invention relates to novel compounds having the structural formula (I) below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
摘要翻译： 本发明涉及具有以下结构式（I）的新化合物：及其药学上可接受的盐，组合物和使用方法。 这些新型化合物提供了认知障碍，阿尔茨海默病，神经变性和痴呆的治疗或预防。
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3.发明公开AMINO-IMIDAZOLONES AND THEIR USE AS A MEDICAMENT FOR TREATING COGNITIVE IMPAIRMENT, ALZHEIMER DISEASE, NEURODEGENERATION AND DEMENTIA. 审中-公开AMINOIMIDAZOLONE和它们作为治疗认知障碍阿尔茨海默氏症，老年痴呆症和神经变性治疗
公开(公告)号：EP2035424A1
公开(公告)日：2009-03-18
申请号：EP07748235.4
申请日：2007-06-12
发明人： BERG, Stefan , HOLENZ, Jörg , HÖGDIN, Katharina , KIHLSTRÖM, Jacob , KOLMODIN, Karin , LINDSTRÖM, Johan , PLOBECK, Niklas , ROTTICCI, Didier , SEHGELMEBLE, Fernando , EK, Maria
IPC分类号： C07D487/04 , A61K31/519 , A61P25/28
CPC分类号： C07D487/04
摘要： This invention relates to novel compounds having the structural formula (I) and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
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公开(公告)号：EP3176172B1
公开(公告)日：2020-01-29
申请号：EP17150757.7
申请日：2011-12-21
申请人： Astrazeneca AB
发明人： CSJERNYIK, Gabor , KARLSTRÖM, Sofia , KERS, Annika , KOLMODIN, Karin , NYLÖF, Martin , ÖHBERG, Liselotte , RAKOS, Laszlo , SANDBERG, Lars , SEHGELMEBLE, Fernando , SÖDERMAN, Peter , SWAHN, Britt-Marie , VON BERG, Stefan
IPC分类号： C07D491/107 , A61K31/4184 , A61K31/4188 , A61K31/4439 , A61K31/506 , A61P25/28 , C07D401/04 , C07D235/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D491/20
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公开(公告)号：EP2864296A1
公开(公告)日：2015-04-29
申请号：EP13731448.0
申请日：2013-06-20
申请人： Astrazeneca AB
发明人： KARLSTRÖM, Sofia , CSJERNYIK, Gabor , SWAHN, Britt-Marie , SANDBERG, Lars , KOLMODIN, Karin , SÖDERMAN, Peter , ÖHBERG, Liselotte
IPC分类号： C07D235/02 , A61K31/4184 , A61P25/28 , C07D401/04 , A61K31/4439
CPC分类号： C07D235/02 , A61K31/4184 , A61K31/4439 , A61K45/06 , C07D401/02 , C07D401/04
摘要： 2H-imidazol-4-amine compounds, therapeutically acceptable salts thereof, processes for preparation thereof, therapeutic uses of such compounds for treating Αβ-related pathologies such as Down's syndrome, β-amyloid angiopathy, Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration methods of therapy, and pharmaceutical compositions containing such compounds. Formula (I) wherein A is -O- or -CH
2 -, n is 1 or 1.-
6.发明公开SUBSTITUTED 2-AMINOPYRIMIDINE-4-ONES, THEIR PHARMACEUTICAL COMPOSITIONS AND THEIR USE IN THE TREATMENT AND/OR PREVENTION OF Aß-RELATED PATHOLOGIES 审中-公开取代的2-氨基嘧啶-4-酮，其药物组合物及其用途在治疗和/或预防ASS-介导的疾病
公开(公告)号：EP1966160A1
公开(公告)日：2008-09-10
申请号：EP06835855.5
申请日：2006-12-18
IPC分类号： C07D239/22 , A61K31/513 , A61P25/00 , C07D405/10
CPC分类号： C07D239/22 , C07D405/10 , C07F5/025
摘要： This invention relates to novel compounds having the structural formula (I) below: [Chemical formula should be inserted here. Please see paper copy] and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
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公开(公告)号：EP2655378B1
公开(公告)日：2017-03-01
申请号：EP11850232.7
申请日：2011-12-21
申请人： AstraZeneca AB
发明人： CSJERNYIK, Gabor , KARLSTRÖM, Sofia , KERS, Annika , KOLMODIN, Karin , NYLÖF, Martin , ÖHBERG, Liselotte , RAKOS, Laszlo , SANDBERG, Lars , SEHGELMEBLE, Fernando , SÖDERMAN, Peter , SWAHN, Britt-Marie , VON BERG, Stefan
IPC分类号： C07D491/107 , A61K31/4184 , A61K31/4188 , A61K31/4439 , A61K31/506 , A61P25/28 , C07D401/04 , C07D235/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D491/20
CPC分类号： A61K31/497 , A61K31/4184 , A61K31/4188 , A61K31/437 , A61K31/4439 , A61K31/506 , A61K45/06 , A61K2300/00 , C07D235/02 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D471/04 , C07D491/107 , C07D491/20
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">8.发明公开CYCLOHEXANE-1,2'-NAPHTHALENE-1',2"-IMIDAZOLE COMPOUNDS AND THEIR USE AS BACE INHIBITORS 审中-公开环己烷-1,2'-萘-1”，2 - 咪唑及其作为BACE抑制剂
公开(公告)号：EP2864314A1
公开(公告)日：2015-04-29
申请号：EP13731450.6
申请日：2013-06-20
申请人： Astrazeneca AB
IPC分类号： C07D401/04 , A61K31/4188 , C07D491/107
CPC分类号： C07D235/02 , A61K31/4184 , A61K31/4439 , A61K45/06 , C07D401/02 , C07D401/04 , C07D491/107
摘要： Cyclohexane-1,2'-naphthalene-1',2''-imidazole compounds, therapeutically acceptable salts thereof, processes for preparation thereof, therapeutic uses of such compounds for treating Aβ-related pathologies such as Down's syndrome, β-amyloid angiopathy, Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration, methods of therapy using such compounds, and pharmaceutical compositions containing such compounds.
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9.发明公开AMINO- IMIDAZOLONES AND THEIR USE AS A MEDICAMENT FOR TREATING COGNITIVE IMPAIRMENT, ALZHEIMER DISEASE, NEURODEGENERATION AND DEMENTIA. 审中-公开氨基咪唑啉酮及其用作治疗认知障碍，阿尔茨海默病，神经退化和痴呆的药物。
公开(公告)号：EP2035425A1
公开(公告)日：2009-03-18
申请号：EP07748236.2
申请日：2007-06-12
发明人： BERG, Stefan , HOLENZ, Jörg , HÖGDIN, Katharina , KOLMODIN, Karin , PLOBECK, Niklas , ROTTICCI, Didier , SEHGELMEBLE, Fernando
IPC分类号： C07D487/04 , A61K31/519 , A61P25/28
CPC分类号： C07D487/04
摘要： This invention relates to novel compounds having the structural formula I below and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
摘要翻译： 本发明涉及具有下述结构式I的新化合物及其药学上可接受的盐，组合物和使用方法。 这些新型化合物提供了认知障碍，阿尔茨海默病，神经变性和痴呆的治疗或预防。
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公开(公告)号：EP2035378A1
公开(公告)日：2009-03-18
申请号：EP07748264.4
申请日：2007-06-20
发明人： ARNOLD, James , BERG, Stefan , CHESSARI, Gianni , CONGREVE, Miles , EDWARDS, Phil , HOLENZ, Jörg , KERS, Annika , KOLMODIN, Karin , MURRAY, Christopher , PATEL, Sahil , RAKOS, Laszlo , ROTTICCI, Didier , SYLVESTER, Mark , ÖHBERG, Liselotte
IPC分类号： C07D209/44 , A61K31/4035 , A61K31/4433 , A61K31/4439 , A61K31/506 , A61P25/28 , C07D401/10 , C07D403/10 , C07D407/14
CPC分类号： A61K31/4035 , A61K31/4433 , A61K31/4439 , A61K31/506 , C07D209/44 , C07D401/10 , C07D401/14 , C07D403/10 , C07D405/14 , C07D513/04
摘要： This invention relates to novel compounds having the structural formula I and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
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