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1.发明公开PHARMACEUTICAL PRODUCT COMPRISING A P38 KINASE INHIBITOR AND A SECOND ACTIVE INGREDIENT 审中-公开药物含有p38激酶抑制剂和皮质类固醇
公开(公告)号：EP2379174A1
公开(公告)日：2011-10-26
申请号：EP09833746.2
申请日：2009-12-17
申请人： AstraZeneca AB
IPC分类号： A61P11/06 , A61K31/4965 , A61K31/416 , A61K31/444 , A61K31/4545
CPC分类号： A61K31/4965 , A61K31/416 , A61K31/428 , A61K31/444 , A61K31/4545 , A61K31/56 , A61K45/06 , A61K2300/00
摘要： The invention provides a pharmaceutical product, kit or composition comprising a first active ingredient which is N-Cyclopropyl-3-fluoro-4-methyl-5-[3-[[l-[2-[2- (methylamino)ethoxy]phenyl]cyclopropyl]amino]-2-oxo-l(2H)-pyrazinyl]- benzamide or a salt thereof, and a second active ingredient selected from: a non-steroidal Glucocorticoid Receptor (GR Receptor) Agonist; an antioxidant; a β2 adrenoceptor agonist; a CCRl antagonist; a chemokine antagonist (not CCRl); a corticosteroid; a CRTh2 antagonist; a DPI antagonist; an Ηistone Deacetylase activator; an IKK2 kinase inhibitor; a COX inhibitor; a lipoxygenase inhibitor; a leukotriene receptor antagonist; a MABA compound; an MPO inhibitor; a muscarinic antagonist; a PDE4 inhibitor; a PPARγ agonist; a protease inhibitor; a Statin; a thromboxane antagonist; a vasodilator; or, an ENAC blocker (Epithelial Sodium-channel blocker); and its use in the treatment of respiratory disease.
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2.发明公开SUBSTITUTED PHENYL COMPOUNDS WITH IMMUNOSUPPRESSING ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开具有免疫抑制作用和PHARMAZUTISCHE组合物您是否提供取代苯基
公开(公告)号：EP1185522A1
公开(公告)日：2002-03-13
申请号：EP00931406.3
申请日：2000-05-22
申请人： AstraZeneca AB
发明人： FURBER, Mark , LUKER, Timothy Jon , MORTIMORE, Michael Paul,Vertex Pharm.(Europe)Ltd. , THORNE, Philip , MEGHANI, Premji
IPC分类号： C07D295/12 , C07D295/08 , C07D295/18 , C07D207/09 , A61K31/40 , A61K31/445 , A61K31/495 , A61P37/06 , C07D211/46 , C07D207/14 , C07D207/08 , C07D239/42 , C07D233/61 , C07C237/34 , C07C237/20
CPC分类号： C07D207/08 , C07C237/20 , C07C237/34 , C07D207/09 , C07D207/14 , C07D211/46 , C07D231/12 , C07D233/56 , C07D239/42 , C07D249/08 , C07D295/088 , C07D295/135 , C07D295/185
摘要： The invention provides substituted phenyl compounds of general formula (I) wherein R1, T, U and Ar are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy.
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3.发明授权PHENOXYACETIC ACID DERIVATIVES USEFUL FOR TREATING RESPIRATORY DISEASES 有权呼吸系统疾病SUITABLE苯氧基乙酸衍生物的治疗
公开(公告)号：EP1817282B1
公开(公告)日：2011-07-20
申请号：EP05807437.8
申请日：2005-11-22
申请人： AstraZeneca AB
发明人： BONNERT, Roger Victor , ALCARAZ, Lilian , MOHAMMED, Rukhsana Tasneem , COOK, Anthony Ronald , THOM, Stephen , LUKER, Timothy Jon
IPC分类号： C07D207/48 , C07C59/72 , C07D333/24 , C07D213/34 , C07D213/56 , C07D241/08 , A61K31/495 , A61P11/00
CPC分类号： C07D333/24 , C07D207/48 , C07D213/34 , C07D213/56 , C07D241/08
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4.发明公开PHENOXYACETIC ACID DERIVATIVES USEFUL FOR TREATING RESPIRATORY DISEASES 有权呼吸系统疾病SUITABLE苯氧基乙酸衍生物的治疗
公开(公告)号：EP1817282A1
公开(公告)日：2007-08-15
申请号：EP05807437.8
申请日：2005-11-22
申请人： AstraZeneca AB
发明人： BONNERT, Roger Victor , ALCARAZ, Lilian , MOHAMMED, Rukhsana Tasneem , COOK, Anthony Ronald , THOM, Stephen , LUKER, Timothy Jon
IPC分类号： C07D207/48 , C07C59/72 , C07D333/24 , C07D213/34 , C07D213/56 , C07D241/08 , A61K31/495 , A61P11/00
CPC分类号： C07D333/24 , C07D207/48 , C07D213/34 , C07D213/56 , C07D241/08
摘要： The invention relates to substituted phenoxyacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.Formula (I)
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