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1.发明公开SUBSTITUTED 2-AMINOPYRIMIDINE-4-ONES, THEIR PHARMACEUTICAL COMPOSITIONS AND THEIR USE IN THE TREATMENT AND/OR PREVENTION OF Aß-RELATED PATHOLOGIES 审中-公开取代的2-氨基嘧啶-4-酮，其药物组合物及其用途在治疗和/或预防ASS-介导的疾病
公开(公告)号：EP1966160A1
公开(公告)日：2008-09-10
申请号：EP06835855.5
申请日：2006-12-18
IPC分类号： C07D239/22 , A61K31/513 , A61P25/00 , C07D405/10
CPC分类号： C07D239/22 , C07D405/10 , C07F5/025
摘要： This invention relates to novel compounds having the structural formula (I) below: [Chemical formula should be inserted here. Please see paper copy] and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
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2.发明公开
公开(公告)号：EP1979324A2
公开(公告)日：2008-10-15
申请号：EP06813032.7
申请日：2006-11-20
发明人： BERG, Stefan , BURROWS, Jeremy , CHESSARI, Gianni , CONGREVE, Miles, Stuart , HEDSTRÖM, Johan , HELLBERG, Sven , HÖGDIN, Katharina , KIHLSTRÖM, Jacob , KOLMODIN, Karin , LINDSTRÖM, Johan , MURRAY, Christopher , PATEL, Sahil
IPC分类号： C07D233/88 , A61K31/4168 , A61K31/4174 , A61K31/4178 , A61K31/427 , A61K31/4439 , A61K31/4725 , A61K31/497 , A61K31/506 , A61K31/538 , A61P25/16 , A61P25/28 , C07D233/86 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/04 , C07D405/10 , C07D405/14 , C07D409/10 , C07D413/10
CPC分类号： C07D233/88 , C07C25/22 , C07C25/24 , C07C39/373 , C07C43/1747 , C07C43/23 , C07C47/575 , C07C49/792 , C07C49/813 , C07C49/83 , C07C49/84 , C07D209/08 , C07D217/06 , C07D233/86 , C07D265/36 , C07D307/79 , C07D339/08 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/10 , C07D417/04 , C07F7/1856
摘要： This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
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公开(公告)号：EP1368314A1
公开(公告)日：2003-12-10
申请号：EP02700965.3
申请日：2002-02-27
申请人： AstraZeneca AB
发明人： BURROWS, Jeremy , CUMMING, John , TUCKER, Howard
IPC分类号： C07D211/58 , C07D453/02 , C07D265/30 , C07D401/12 , C07D405/12 , C07D413/12 , A61K31/443 , A61K31/4439 , A61K31/444 , A61P29/00
CPC分类号： C07D401/12 , C07D211/58 , C07D211/60 , C07D211/62 , C07D405/12 , C07D413/12 , C07D417/12 , C07D453/02
摘要： The invention provides a compound of formula (1): wherein R?1, R2, R3, R3a, R4, R4a, R5, and R6¿ are as defined; or a pharmaceutically acceptable salt thereof or a solvate thereof; compositions containing these compounds, processes for preparing them and their use as modulators of chemokine activity (especially CCR5 activity).
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4.发明公开IMIDAZOL-PYRIMIDINE DERIVATIVES FOR TREATMENT OF DISEASES RELATED TO GLYCOGEN SYNTHASE KINASE (GSK3) 审中-公开IMIDAZOLPYRIMIDINDERIVATE与糖原合酶激酶（GSK3）对待连接相关疾病
公开(公告)号：EP2046783A2
公开(公告)日：2009-04-15
申请号：EP07748282.6
申请日：2007-06-26
申请人： AstraZeneca AB
发明人： BURROWS, Jeremy , HUERTA, Fernando , REIN, Tobias , ROTTICCI, Didier , STAAF, Karin , TUREK, Dominika
IPC分类号： C07D405/14 , A61K31/506 , A61P25/28 , C07D501/14 , C07D403/14
CPC分类号： C07D403/14 , C07D403/04 , C07D405/14
摘要： The present invention relates to a compound of formula (I) as a free base or a pharmaceutically acceptable salt thereof. The present invention also relates to pharmaceutical formulations containing said compound and to the use of said compound in therapy. The present invention further relates to a process for the preparation of the compound of formula (I).
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5.发明公开NEW PYRIMIDINE DERIVATIVES AND THEIR USE IN THERAPY AS WELL AS THE USE OF PYRIMIDINE DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR PREVENTION AND/OR TREATMENT OF ALZHEIMER'S DISEASE 审中-公开NEW嘧啶衍生物及其在治疗和嘧啶的药物在制备用于预防和/或治疗阿尔茨海默病的用途
公开(公告)号：EP1945628A1
公开(公告)日：2008-07-23
申请号：EP06799716.3
申请日：2006-10-02
申请人： AstraZeneca AB
发明人： ANDERSSON, Lars , ARZEL, Erwan , BERG, Stefan , BURROWS, Jeremy , HELLBERG, Sven , HUERTA, Fernando , PEDERSEN, Torben , REIN, Tobias , ROTTICCI, Didier , STAAF, Karin , TUREK, Dominika
IPC分类号： C07D403/04 , A61K31/506 , A61P25/16 , A61P25/28 , A61P3/10 , C07D401/14 , C07D405/14
CPC分类号： C07D405/14 , A61K31/506 , C07D401/14 , C07D403/04 , C07D409/14
摘要： The present invention relates to use of compounds of formula (I) as a free base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, a process for their preparation and new intermediates used therein, as pharmaceutical ingredients for treatment of dementia, Alzheimer's Disease, Parkinson's Disease, Frontotemporal dementia Parkinson's Type, Parkinson dementia complex of Guam, HIV dementia, diseases with associated neurofibrillar tangle pathologies and/or dementia pugilistica .
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6.发明公开USE OF PYRIMIDINE DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR PREVENTION AND/OR TREATMENT OF ALZHEIMER'S DISEASE 审中-公开嘧啶衍生物的药物用于预防和/或治疗阿尔茨海默氏病的制造中使用
公开(公告)号：EP1942897A1
公开(公告)日：2008-07-16
申请号：EP06799712.2
申请日：2006-10-02
申请人： AstraZeneca AB
发明人： ANDERSSON, Lars , BERG, Stefan , BURROWS, Jeremy , HELLBERG, Sven , HUERTA, Fernando , REIN, Tobias
IPC分类号： A61K31/506 , A61P19/08 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P3/10 , C07D401/14 , C07D403/04
CPC分类号： C07D403/04 , A61K31/506 , C07D401/14
摘要： The present invention relates to a new use of pyrimidine derivatives of formula I, as a free base or a pharmaceutically acceptable salt thereof in the manufacture of a medicament in the treatment and/or prophylaxis of Alzheimer's Disease:
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公开(公告)号：EP2142542A1
公开(公告)日：2010-01-13
申请号：EP08724302.8
申请日：2008-03-28
申请人： AstraZeneca AB
IPC分类号： C07D471/04 , A61K31/437 , A61K31/5375 , A61P19/08 , A61P25/00 , A61P25/28 , A61P3/10
CPC分类号： C07D471/04
摘要： The present invention relates to new compounds of formula (I) as a free base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, a process for their preparation and new intermediates used therein, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in therapy.
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8.发明公开NOVEL IMIDAZO [4,5 -B] PYRIDINE DERIVATIVES AS INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 FOR USE IN THE TREATMENT OF DEMENTIA AND NEURODEGENERATIVE DISORDERS 审中-公开NEW咪唑并[4,5-b]吡啶衍生物作为FOR USE IN痴呆和神经变性疾病的治疗糖原合酶激酶3抑制剂
公开(公告)号：EP1937680A2
公开(公告)日：2008-07-02
申请号：EP06799714.8
申请日：2006-10-02
申请人： AstraZeneca AB
发明人： ARVIDSSON, Per I , ARZEL, Erwan , BURROWS, Jeremy , CLAESSON, Martina , RAY, Colin , REIN, Tobias , ROTTICCI, Didier , SÖDERMAN, Peter
IPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/501 , A61K31/551 , A61P19/08 , A61P25/00 , A61P25/28 , A61P3/10
CPC分类号： C07D471/04
摘要： The present invention relates to new compounds of formula (I) Wherein X is or Y; as a free base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, a process for their preparation and new intermediates used therein, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in therapy.
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9.发明公开PHARMACEUTICALLY ACTIVE PIPERIDINE DERIVATIVES, IN PARTICULAR AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY 审中-公开药学有效哌啶，尤其是作为活动CHEMOKININREZEPTOREN的调节剂的
公开(公告)号：EP1289957A1
公开(公告)日：2003-03-12
申请号：EP01932457.3
申请日：2001-05-14
申请人： AstraZeneca AB
IPC分类号： C07D211/58 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D411/12 , C07D413/12 , C07D413/14 , A61K31/4468 , A61K31/4523 , A61P1/00 , A61P11/00 , A61P17/00 , A61P19/00
CPC分类号： C07D401/04 , C07D211/58 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： Compounds of formula (I), compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).
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公开(公告)号：EP1265870A1
公开(公告)日：2002-12-18
申请号：EP01918028.0
申请日：2001-03-06
申请人： AstraZeneca AB
发明人： BURROWS, Jeremy , CUMMING, John , MCINALLY, Thomas
IPC分类号： C07D235/04 , C07D249/18 , A61K31/4192 , A61K31/4184 , A61K31/445 , A61P31/12
CPC分类号： C07D401/04 , C07D401/14 , C07D409/14 , C07D471/04
摘要： The invention concerns compounds of formula (I), wherein the variables are defined herein; processes for preparing them, compositions comprising them and their use in modulating CCR5 receptor activity.
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