-
公开(公告)号：EP1831170A1
公开(公告)日：2007-09-12
申请号：EP05815781.9
申请日：2005-12-12
发明人： ALBERT, Jeffrey Scott AstraZeneca Wilmington , CALLAGHAN, Owen , CAMPBELL, James AstraZeneca Wilmington , CARR, Robin, Arthur, Ellis , CHESSARI, Gianni Astex Therapeutics , COWAN, Suzanna , CONGREVE, Miles Stuart Astex Therapeutics , EDWARDS, Phil AstraZeneca Wilmington , FREDERICKSON, Martyn Astex Therapeutics , MURRAY, Christopher William Astex Therapeutics , PATEL, Sahil Astex Therapeutics
IPC分类号： C07D213/73 , A61K31/44 , A61P25/16 , A61P25/28
CPC分类号： C07D213/73 , C07D213/74 , C07D213/81 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/10 , C07D409/14 , C07D413/12
摘要： This invention relates to novel compounds having the structural formula (I) and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
-
公开(公告)号：EP2049497A2
公开(公告)日：2009-04-22
申请号：EP06727141.1
申请日：2006-05-19
发明人： CHESSARI, Gianni , CONGREVE, Miles Stuart , CALLAGHAN, Owen , COWAN, Suzanna Ruth , MURRAY, Christopher William , WOOLFORD, Alison, Jo-Anne , O'BRIEN, Michael Alistair , WOODHEAD, Andrew James
IPC分类号： C07D239/42 , C07D251/18 , C07D401/04 , C07D403/04
CPC分类号： C07D413/04 , C07D239/42 , C07D239/47 , C07D239/48 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D409/04
摘要： The invention provides a compound for use as an inhibitor of Hsp90, the compound having the formula (I): or salts, tautomers, solvates or N-oxides thereof; wherein: A is N or a group CR3; R1 is a monocyclic or bicyclic carbocyclic or heterocyclic ring of 5 to 10 ring members of which up to two ring members may be heteroatoms selected from N, O and S and the remainder are carbon atoms, the carbocyclic or heterocyclic ring being optionally substituted by one or more substituent groups independently selected from R10; and R2, R3 and R10 are as defined in the claims.
-
公开(公告)号：EP2114941B1
公开(公告)日：2015-03-25
申请号：EP07848659.4
申请日：2007-12-21
发明人： BERDINI, Valerio , BESONG, Gilbert, Ebai , CALLAGHAN, Owen , CARR, Maria, Grazia , CONGREVE, Miles, Stuart , GILL, Adrian, Liam , GRIFFITHS-JONES, Charlotte, Mary , MADIN, Andrew , MURRAY, Christopher, William , NIJJAR, Rajdeep, Kaur , O'BRIEN, Michael, Alistair , PIKE, Andrew , SAXTY, Gordon , TAYLOR, Richard, David , VICKERSTAFFE, Emma
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04 , A61K31/437 , C07D471/04
-
公开(公告)号：EP2121687B1
公开(公告)日：2015-10-14
申请号：EP07848681.8
申请日：2007-12-21
发明人： BERDINI, Valerio , BESONG, Gilbert Ebai , CALLAGHAN, Owen , CARR, Maria Grazia , CONGREVE, Miles Stuart , GILL, Adrian Liam , GRIFFITHS-JONES, Charlotte Mary , MADIN, Andrew , MURRAY, Christopher William , NIJJAR, Rajdeep Kaur , O'BRIEN, Michael Alistair , PIKE, Andrew , SAXTY, Gordon , TAYLOR, Richard David , VICKERSTAFFE, Emma
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , C07D487/04
-
公开(公告)号：EP2114941A1
公开(公告)日：2009-11-11
申请号：EP07848659.4
申请日：2007-12-21
发明人： BERDINI, Valerio , BESONG, Gilbert, Ebai , CALLAGHAN, Owen , CARR, Maria, Grazia , CONGREVE, Miles, Stuart , GILL, Adrian, Liam , GRIFFITHS-JONES, Charlotte, Mary , MADIN, Andrew , MURRAY, Christopher, William , NIJJAR, Rajdeep, Kaur , O'BRIEN, Michael, Alistair , PIKE, Andrew , SAXTY, Gordon , TAYLOR, Richard, David , VICKERSTAFFE, Emma
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04 , A61K31/437 , C07D471/04
摘要： The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
-
公开(公告)号：EP2121687A2
公开(公告)日：2009-11-25
申请号：EP07848681.8
申请日：2007-12-21
发明人： BERDINI, Valerio , BESONG, Gilbert Ebai , CALLAGHAN, Owen , CARR, Maria Grazia , CONGREVE, Miles Stuart , GILL, Adrian Liam , GRIFFITHS-JONES, Charlotte Mary , MADIN, Andrew , MURRAY, Christopher William , NIJJAR, Rajdeep Kaur , O'BRIEN, Michael Alistair , PIKE, Andrew , SAXTY, Gordon , TAYLOR, Richard David , VICKERSTAFFE, Emma
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , C07D487/04
摘要： The invention relates to new bicyclic heterocyclic derivative compounds of Formula (I), to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer. The compounds of Formula (I) are inhibitors of FGFR, VEGFR or PDGFR.
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.023 秒)
