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    IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER
    1.
    发明授权
    IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER 有权
    咪唑[4,5-C]喹啉-2-酮类化合物及其在治疗癌症中的应用

    公开(公告)号：EP3140303B1

    公开(公告)日：2018-03-28

    申请号：EP15724351.0

    申请日：2015-05-05

    申请人： Astrazeneca AB

    发明人： BARLAAM, Bernard Christophe ,  PIKE, Kurt Gordon

    IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P35/00

    CPC分类号： C07D471/04 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4745 ,  A61K31/502 ,  A61K45/06

    摘要： The specification generally relates to compounds of Formula (I): and pharmaceutically acceptable salts thereof, where Q, R1, R2, R3, R4 and R5 have any of the meanings defined herein. The specification also relates to the use of such compounds and salts thereof to treat or prevent ATM kinase mediated disease, including cancer. The specification further relates to crystalline forms of compounds of imidazo[4,5-c]quinolin-2-one compounds and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds and salts; kits comprising such compounds and salts; methods of manufacture of such compounds and salts; intermediates useful in the manufacture of such compounds and salts; and to methods of treating ATM kinase mediated disease, including cancer, using such compounds and salts.

    IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER
    5.
    发明公开
    IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER 有权
    咪达唑[4,5-C] CHINOLIN-2-ON-VERBINDUNGEN UND DEREN VERWENDUNG BEI DER BEHANDLUNG VON KREBS

    公开(公告)号：EP3140303A1

    公开(公告)日：2017-03-15

    申请号：EP15724351.0

    申请日：2015-05-05

    申请人： Astrazeneca AB

    发明人： BARLAAM, Bernard Christophe ,  PIKE, Kurt Gordon

    IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P35/00

    CPC分类号： C07D471/04 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4745 ,  A61K31/502 ,  A61K45/06

    摘要： The specification generally relates to compounds of Formula (I): and pharmaceutically acceptable salts thereof, where Q, R1, R2, R3, R4 and R5 have any of the meanings defined herein. The specification also relates to the use of such compounds and salts thereof to treat or prevent ATM kinase mediated disease, including cancer. The specification further relates to crystalline forms of compounds of imidazo[4,5-c]quinolin-2-one compounds and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds and salts; kits comprising such compounds and salts; methods of manufacture of such compounds and salts; intermediates useful in the manufacture of such compounds and salts; and to methods of treating ATM kinase mediated disease, including cancer, using such compounds and salts.

    摘要翻译： 本说明书通常涉及式（I）的化合物及其药学上可接受的盐，其中Q，R 1，R 2，R 3，R 4和R 5具有本文定义的任何含义。 本说明书还涉及这些化合物及其盐在治疗或预防ATM激酶介导的疾病（包括癌症）中的应用。 本说明书还涉及咪唑并[4,5-c]喹啉-2-酮化合物及其药学上可接受的盐的结晶形式; 包含这些化合物和盐的药物组合物; 包含这些化合物和盐的试剂盒; 制造这种化合物和盐的方法; 可用于制造这些化合物和盐的中间体; 以及使用这种化合物和盐来治疗ATM激酶介导的疾病（包括癌症）的方法。