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公开(公告)号：EP3515910A1
公开(公告)日：2019-07-31
申请号：EP17772381.4
申请日：2017-09-21
申请人： Astrazeneca AB
发明人： PERRY, Matthew , KARABELAS, Konstantinos , MOGEMARK, Mickael , BOLD, Peter , TYRCHAN, Christian , NIKITIDIS, Antonios , PETERSEN, Jens , BÖRJESSON, Ulf
IPC分类号： C07D417/14 , C07D471/04 , C07D487/04 , A61K31/4439 , A61P11/06 , A61P11/00
摘要： There are disclosed certain novel compounds (including pharmaceutically acceptable salts thereof) (I) that inhibit phosphatidylinositol 3-kinase gamma (PI3Kδ) and phosphatidylinositol 3-kinase gamma (ΡΙ3Κγ) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.
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2.发明公开
公开(公告)号：EP3292104A1
公开(公告)日：2018-03-14
申请号：EP16720441.1
申请日：2016-05-04
申请人： Astrazeneca AB
发明人： RONN, Robert , LINDH, Carl, Jonas , RINGBERG, Erik , ANDERSSON, Hanna, Birgitta, Ellinor , NILSSON, Peter , SCHAAL, Wesley, Ralph , MUNCK AF ROSENSCHÖLD, Magnus , NIKITIDIS, Antonios , NIKITIDIS, Grigorios , JOHANNESSON, Petra , TYRCHAN, Christian
IPC分类号： C07D213/74 , C07D401/08 , C07D239/42 , C07D241/20 , A61K31/44 , A61K31/4439 , A61K31/496 , A61K31/505 , A61P11/00 , A61P29/00
CPC分类号： A61K31/4965 , A61K31/44 , A61K31/4439 , A61K31/496 , A61K31/505 , C07C211/55 , C07C211/58 , C07D213/74 , C07D215/38 , C07D239/42 , C07D239/47 , C07D241/20 , C07D401/08 , C07D401/12 , C07D405/12
摘要： wherein E1, E2, E3, E4, L1, Y1, Y2, Y3, Ra and z have meanings provided in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of leukotriene C4 synthase is desired and/or required, and particularly in the treatment of respiratory diseases and inflammation.
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公开(公告)号：EP3515910B1
公开(公告)日：2020-07-15
申请号：EP17772381.4
申请日：2017-09-21
申请人： Astrazeneca AB
发明人： PERRY, Matthew , KARABELAS, Konstantinos , MOGEMARK, Mickael , BOLD, Peter , TYRCHAN, Christian , NIKITIDIS, Antonios , PETERSEN, Jens , BÖRJESSON, Ulf
IPC分类号： C07D417/14 , C07D471/04 , C07D487/04 , A61K31/4439 , A61P11/06 , A61P11/00
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4.发明授权2-PYRIDONE DERIVATIVES AS NEUTROPHIL ELASTASE INHIBITORS AND THEIR USE 有权2-吡啶酮衍生物作为嗜中性弹性蛋白酶和它们的使用抑制剂
公开(公告)号：EP1663973B1
公开(公告)日：2013-12-25
申请号：EP04775438.7
申请日：2004-09-15
申请人： AstraZeneca AB
IPC分类号： C07D211/86 , C07D241/08 , A61K31/4412 , A61P29/00
CPC分类号： C07D213/82 , C04B35/632 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04
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5.发明公开
公开(公告)号：EP1718615A1
公开(公告)日：2006-11-08
申请号：EP05704807.6
申请日：2005-02-07
申请人： AstraZeneca AB
发明人： DAVID, Laurent , GUSTAFSSON, Jörgen , LAWITZ, Karolina , MUSSIE, Tesfaledet , NIKITIDIS, Antonios
IPC分类号： C07D215/54 , C07D401/12 , C07D413/12 , C07D417/12 , A61K31/47 , A61P37/00 , A61P11/06
CPC分类号： C07D409/12 , C07D215/54 , C07D401/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to novel compounds which are JAK3 Kinase inhibitors, methods for their preparation and pharmaceutical compositions comprising them. A compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein X is -CHOH or -C=O;
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6.发明公开SOME 2-PYRAZINONE DERIVATIVES AND THEIR USE AS INHIBITORS OF NEUTROPHILE ELASTASE 审中-公开2 PYRAZINONDERIVATE及其作为抑制剂中性粒细胞弹性
公开(公告)号：EP2217591A1
公开(公告)日：2010-08-18
申请号：EP08847756.7
申请日：2008-11-05
申请人： AstraZeneca AB
发明人： AINGE, Debra , CHAPMAN, David , LINDSJÖ, Martin , LÖNN, Hans , LUNDKVIST, Michael , MUNCK AF ROSENSCHÖLD, Magnus , NIKITIDIS, Antonios , PAVEY, John
IPC分类号： C07D403/04 , A61K31/497 , A61P1/04 , A61P11/00 , A61P19/00 , C07D401/14
CPC分类号： C07D401/14 , C07D403/04
摘要： The invention provides certain novel 6-heteroaryl-5-methyl-3- oxo-4- [3 (trif luoromethyl) phenyl] -3,4-dihydropyrazine-2- carboxamide derivatives and pharmaceutically acceptable salts thereof and particular Forms thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitord of human neutrophil elastase.
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7.发明授权2-PYRIDONE DERIVATIVES AS NETROPHIL ELASTASE INHIBITORS AND THEIR USE 有权2-吡啶酮衍生物作为嗜中性弹性蛋白酶和它们的使用抑制剂
公开(公告)号：EP1663974B1
公开(公告)日：2009-01-14
申请号：EP04775439.5
申请日：2004-09-15
申请人： AstraZeneca AB
IPC分类号： C07D211/86 , C07D241/08 , A61K31/4412 , A61P29/00
CPC分类号： C07D213/82 , C07D213/85 , C07D401/04
摘要： There are provided novel compounds of formula (I), wherein R1, R2, R4, R5, G1, G2, L, Y and n are as defined in the Specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of neutrophil elastase.
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8.发明公开NOVEL COMPOUNDS II 2-PYRIDINE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE. 审中-公开新的连接II 2 - 吡啶衍生物如中性白细胞弹性蛋白酶的抑制剂
公开(公告)号：EP1861371A1
公开(公告)日：2007-12-05
申请号：EP06717013.4
申请日：2006-03-14
申请人： AstraZeneca AB
发明人： BRIMERT, Thomas , LAWITZ, Karolina , LÖNN, Hans , NIKITIDIS, Antonios , RAY, Asim, Kumar , SANDMARK, Jenny
IPC分类号： C07D213/82 , A61K31/4412 , A61K31/4427 , A61K31/444 , A61P11/00 , A61P11/06 , A61P29/00 , C07D213/83 , C07D401/12 , C07D409/12 , C07D413/12
CPC分类号： C07D213/82 , C07D413/12 , C07D413/14
摘要： The invention provides compounds of formula wherein R1, R3, R4, R5, R6, R14, X, W and Z are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
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公开(公告)号：EP1861370A1
公开(公告)日：2007-12-05
申请号：EP06717012.6
申请日：2006-03-14
申请人： AstraZeneca AB
IPC分类号： C07D213/82 , A61K31/4412 , A61K31/4427 , A61K31/444 , A61P11/00 , A61P11/06 , A61P29/00 , C07D401/12 , C07D413/12 , C07D413/14
CPC分类号： C07D213/82 , C07D413/12 , C07D413/14
摘要： The invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5 and X are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
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10.发明公开2-PYRIDONE DERIVATIVES AS NETROPHIL ELASTASE INHIBITORS AND THEIR USE 有权2-吡啶酮衍生物作为嗜中性弹性蛋白酶和它们的使用抑制剂
公开(公告)号：EP1663974A1
公开(公告)日：2006-06-07
申请号：EP04775439.5
申请日：2004-09-15
申请人： AstraZeneca AB
IPC分类号： C07D211/86 , C07D241/08 , A61K31/4412 , A61P29/00
CPC分类号： C07D213/82 , C07D213/85 , C07D401/04
摘要： There are provided novel compounds of formula (I), wherein R1, R2, R4, R5, G1, G2, L, Y and n are as defined in the Specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of neutrophil elastase.
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