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    OMEGA-TRANSAMINASE OF R CONFIGURATION AND USE THEREOF
    2.
    发明公开
    OMEGA-TRANSAMINASE OF R CONFIGURATION AND USE THEREOF 审中-公开
    OMEGA-TRANSAMINASE MIT R-KONFIGURATION UND DAVON VERWENDUNG

    公开(公告)号：EP3075856A1

    公开(公告)日：2016-10-05

    申请号：EP14865169.8

    申请日：2014-10-29

    申请人： Asymchem Laboratories (Tianjin) Co., Ltd ,  Asymchem Life Science (Tianjin) Co., Ltd ,  Tianjin Asymchem Pharmaceutical Co., Ltd ,  Asymchem Laboratories (Fuxin) Co., Ltd ,  Jilin Asymchem Laboratories Co., Ltd

    发明人： HONG, Hao ,  GAO, Feng ,  LI, Yanjun ,  ZHANG, Yan ,  LI, Shaohe

    IPC分类号： C12N15/54 ,  C12N15/31 ,  C12N15/11 ,  C12N9/10 ,  C12P41/00 ,  C07K14/195

    CPC分类号： C12N9/1096 ,  C12P13/001 ,  C12P17/12 ,  C12P41/006 ,  C12Y206/01

    摘要： An omega-transaminase of R-configuration is provided. The omega-transaminase of R-configuration has the amino acid sequence as shown in SEQ ID NO: 2, or has at least 80% identity to the amino acid sequence as shown in SEQ ID NO: 2, or has the amino acid sequence of proteins which have substituted, deleted or added one or more amino acids and have the activity of an omega-transaminase with a high stereoselectivity R-configuration catalytic activity; and does not have the amino acid sequence encoded by the nucleotide sequence as shown in SEQ ID NO: 4. The high stereoselectivity refers to the content of one of the stereoisomers being at least about 1.1 times that of the other. A use of the omega-transaminase of R-configuration is provided, which can be used for highly efficient synthesis of a chiral amine of R-configuration with a relatively high chiral purity, and is therefore suitable for industrial production of chiral amines.

    摘要翻译： 提供R-构型的ω-转氨酶。 R构型的ω-转氨酶具有如SEQ ID NO：2所示的氨基酸序列，或与SEQ ID NO：2所示的氨基酸序列具有至少80％的同一性，或具有SEQ ID NO：2所示的氨基酸序列 具有取代，缺失或添加一个或多个氨基酸并且具有高立体选择性R构型催化活性的ω-转氨酶活性的蛋白质; 并且不具有由SEQ ID NO：4所示的核苷酸序列编码的氨基酸序列。高立体选择性是指一种立体异构体的含量为至少约1.1倍。 提供R-构型的ω-转氨酶的用途，其可用于高效合成手性纯度较高的R-构型手性胺，因此适用于手性胺的工业生产。