公开(公告)号：EP1882032A2

公开(公告)日：2008-01-30

申请号：EP06749572.1

申请日：2006-04-07

申请人： THE CLEVELAND CLINIC FOUNDATION ,  The Regents of the University of California

发明人： SILVERMAN, Robert ,  KLEIN, Eric, A. ,  DERISI, Joseph ,  GANEM, Don ,  CASEY, Graham

IPC分类号： C12N7/00

CPC分类号： C12N7/00 ,  A61K39/00 ,  C07K14/005 ,  C07K16/1036 ,  C12N9/22 ,  C12N2740/13021 ,  C12N2740/13022 ,  C12Q1/6886 ,  C12Q1/70 ,  C12Q1/701 ,  C12Q2600/136

摘要： The present invention provides for isolated nucleic acid sequences encoding viruses; isolated polypeptides comprising amino acid sequences of the virus; vectors comprising the viral nucleic acid sequences; cells comprising the vectors; antibodies and antigen binding fragments thereof which have binding specificity for the virus; methods of detecting or screening for the virus (e.g., in an individual); methods of identifying agents that inhibit the virus; methods of inducing an immune response to the virus; methods of treating disease associated with the presence of XMRV in an individual (e.g., cancer such as prostate cancer); methods of detecting asymptomatic cancer (e.g., prostate cancer); methods of identifying an individual at risk for developing cancer (e.g., prostate cancer); and kits for detecting the virus.

公开(公告)号：EP0835137B1

公开(公告)日：2005-11-09

申请号：EP96923905.2

申请日：1996-06-24

申请人： Bavarian Nordic A/S ,  GSF-Forschungszentrum für Umwelt und Gesundheit GmbH

发明人： SALLER, Robert, Michael ,  GÜNZBURG, Walter, H. ,  SALMONS, Brian

IPC分类号： A61K48/00 ,  C12N11/04 ,  A61K9/50

CPC分类号： C12N15/86 ,  A61K9/5026 ,  A61K9/5042 ,  A61K48/00 ,  C12N7/00 ,  C12N11/04 ,  C12N2740/13021 ,  C12N2740/13043

公开(公告)号：EP1452540A3

公开(公告)日：2005-03-23

申请号：EP04012223.6

申请日：1996-12-13

申请人： THE GENERAL HOSPITAL CORPORATION

发明人： Fishman, Jay A.

IPC分类号： C12Q1/68 ,  C12Q1/70

CPC分类号： C12N15/8509 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/108 ,  A01K2267/02 ,  A01K2267/025 ,  A01K2267/0337 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2740/13021 ,  C12N2740/13022 ,  C12N2740/13043 ,  C12Q1/6888 ,  C12Q1/702 ,  C12Q2600/156

摘要： Purified nucleic acid which can specifically hybridise with the sequence of swine retroviruses.

摘要翻译： 可以与猪逆转录病毒序列特异性杂交的纯化核酸。

公开(公告)号：EP1019725A2

公开(公告)日：2000-07-19

申请号：EP98943864.3

申请日：1998-07-22

申请人： NOVIMMUNE SA

发明人： CONRAD, Bernard ,  MACH, Bernard

IPC分类号： G01N33/564

CPC分类号： G01N33/5091 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2217/20 ,  A01K2227/105 ,  A01K2267/0325 ,  A61K38/00 ,  C07K14/005 ,  C12N2740/10022 ,  C12N2740/13021 ,  C12N2740/13022 ,  C12Q1/48 ,  C12Q1/686 ,  C12Q1/702 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5047 ,  G01N33/505 ,  G01N33/5052 ,  G01N33/564 ,  G01N33/56977 ,  G01N33/56983 ,  G01N33/68 ,  G01N2333/15 ,  G01N2500/00 ,  G01N2800/042 ,  G01N2800/24

摘要： The invention relates to a process for the diagnosis of a human autoimmune disease, including presymptomatic diagnosis, said human autoimmune disease being associated with human endogenous retrovirus (HERV) having Superantigen (SAg) activity, comprising specifically detecting in a biological sample of human origin at least one of the following: (I) the mRNA of an expressed human endogenous retrovirus having Superantigen (SAg) activity, or fragments of such expressed retroviral mRNA, said retrovirus being associated with a given autoimmune disease, or (II) protein or peptide expressed by said retrovirus, or (III) antibodies specific to the protein expressed by said endogenous retrovirus, or (IV) SAg activity specifically associated with said endogenous retrovirus, detection of any of the species (I) to (IV) indicating presence of autoimmune disease or imminent onset of autoimmune disease.

公开(公告)号：EP3325633A1

公开(公告)日：2018-05-30

申请号：EP16842998.3

申请日：2016-09-01

申请人： Tocagen Inc.

发明人： JOLLY, Douglas, J. ,  LIN, Amy, H. ,  HOFACRE, Andrew ,  OSTERTAG, Derek G. ,  HOGAN, Daniel J.

IPC分类号： C12N15/867 ,  C12N7/01 ,  A61P35/00

CPC分类号： C12N15/86 ,  A61K35/76 ,  A61K48/00 ,  A61K48/005 ,  A61P35/00 ,  C07K14/535 ,  C07K14/70507 ,  C07K16/2827 ,  C07K2317/76 ,  C07K2319/30 ,  C07K2319/50 ,  C07K2319/60 ,  C07K2319/75 ,  C12N15/1138 ,  C12N2310/141 ,  C12N2740/13021 ,  C12N2740/13022 ,  C12N2740/13043 ,  C12N2840/20 ,  C12N2840/203

摘要： This disclosure provides modified recombinant retroviruses comprisings containing a 2A-peptide or peptide-like coding sequence operably linked to a heterologous polynucleotide. The disclosure further relates to cells and vector expressing or comprising such vectors and methods of using such modified vectors in the treatment of disease and disorders.

公开(公告)号：EP1452540A2

公开(公告)日：2004-09-01

申请号：EP04012223.6

申请日：1996-12-13

申请人： THE GENERAL HOSPITAL CORPORATION

发明人： Fishman, Jay A.

IPC分类号： C07K14/47 ,  C12Q1/68

CPC分类号： C12N15/8509 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/108 ,  A01K2267/02 ,  A01K2267/025 ,  A01K2267/0337 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2740/13021 ,  C12N2740/13022 ,  C12N2740/13043 ,  C12Q1/6888 ,  C12Q1/702 ,  C12Q2600/156

摘要： Purified nucleic acid which can specifically hybridise with the sequence of swine retroviruses.

公开(公告)号：EP0699758A1

公开(公告)日：1996-03-06

申请号：EP95100871.3

申请日：1989-12-12

申请人： HARVARD UNIVERSITY ,  COLORADO STATE UNIVERSITY RESEARCH FOUNDATION

发明人： Hoover, Edward A. ,  Mullins, James I.

IPC分类号： C12N15/48 ,  A61K39/21

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K2039/525 ,  C12N7/00 ,  C12N2740/13021 ,  C12N2740/13022 ,  C12N2740/13061 ,  Y10S424/819

摘要： Molecular clones of feline leukemia virus isolates that encode (a) a prototype highly infectious, minimally pathogenic virus, (b) a variant genome that is replication-defective and associated with a fatal immunodeficiency in cats similar to AIDS (FAIDS) or (c) a chimeric genome that is replication-competent and induces FAIDS. These molecular clones may be used to generate cell lines producing infectious virus which is useful in the preparation of vaccines or in the generation of viremia or disease challenge systems.

摘要翻译： 猫科白血病病毒分离株的分子克隆编码（a）原型感染性极低的致病病毒，（b）与艾滋病相似的猫（FAIDS）中复制缺陷并与致命免疫缺陷相关的变异基因组，或（c） 具有复制能力并诱导FAIDS的嵌合基因组。 这些分子克隆可用于产生产生感染性病毒的细胞系，其可用于制备疫苗或产生病毒血症或疾病挑战系统。

公开(公告)号：EP0556339A1

公开(公告)日：1993-08-25

申请号：EP92902210.0

申请日：1991-11-07

申请人： GENENTECH, INC.

发明人： ANDERSON, Kevin, P.

IPC分类号： C12N5 ,  C07K14 ,  C12N7 ,  C12N15 ,  A61K38

CPC分类号： C07K14/005 ,  A61K38/00 ,  C12N7/00 ,  C12N2740/13021 ,  C12N2740/13022

摘要： Particules présentant une activité de transcriptases inverses et associées à des protéines structurelles de rétrovirus de type C mammifères. L'invention concerne également de l'ADN, ainsi que des séquences d'ADN complémentaire de nouvelles particules analogues à un rétrovirus, ainsi que leurs procédés d'utilisation.

公开(公告)号：EP0689601B1

公开(公告)日：2006-10-04

申请号：EP94909777.8

申请日：1994-02-22

申请人： THE ROCKEFELLER UNIVERSITY

发明人： PEAR, Warren, S. ,  NOLAN, Garry, P. ,  SCOTT, Martin, L. ,  BALTIMORE, David

IPC分类号： C12N15/86 ,  C12N5/10 ,  A61K39/00 ,  A61K48/00

CPC分类号： C12N15/86 ,  A61K39/00 ,  A61K48/0091 ,  C12N7/00 ,  C12N2740/13021 ,  C12N2740/13052

摘要： A method for producing high-titer, helper-free infectious retroviruses is disclosed which employs a novel strategy that uses transient transfection of new retroviral producer cell lines, ecotropic line BOSC 23 and amphotropic line CAK 8, both of which cell lines and their precursor cell lines are disclosed. Because of the advantages over stable packaging cell lines, the BOSC 23 and CAK 8 transient transfection systems greatly facilitate and extend the use of helper-free retroviral vectors. The cell lines and corresponding methods possess wide application in both the medical and biotechnical fields, including gene therapy. These potential applications are disclosed and illustrated.

公开(公告)号：EP0870058B1

公开(公告)日：2004-06-02

申请号：EP96944298.7

申请日：1996-12-13

申请人： THE GENERAL HOSPITAL CORPORATION

发明人： FISHMAN, Jay, A.

IPC分类号： C12Q1/68 ,  C12Q1/70

CPC分类号： C12N15/8509 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/108 ,  A01K2267/02 ,  A01K2267/025 ,  A01K2267/0337 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2740/13021 ,  C12N2740/13022 ,  C12N2740/13043 ,  C12Q1/6888 ,  C12Q1/702 ,  C12Q2600/156

摘要： Purified nucleic acid which can specifically hybridize with the sequence of swine retroviruses.