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公开(公告)号：EP0892852B1
公开(公告)日：2004-09-08
申请号：EP97919307.5
申请日：1997-03-27
摘要： A replication-defective retroviral vector carrying a cytochrome P450 gene under transcriptional control of target cell specific regulatory elements or promoters, or X-ray inducible promoters.
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公开(公告)号：EP0835137B1
公开(公告)日：2005-11-09
申请号：EP96923905.2
申请日：1996-06-24
CPC分类号： C12N15/86 , A61K9/5026 , A61K9/5042 , A61K48/00 , C12N7/00 , C12N11/04 , C12N2740/13021 , C12N2740/13043
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3.发明授权NON SELF-INACTIVATING, EXPRESSION TARGETED RETROVIRAL VECTORS 失效有针对性的表达不SELBSTINAKTIVIERENDE RETRO病毒载体
公开(公告)号：EP0779929B1
公开(公告)日：2001-04-11
申请号：EP95931969.0
申请日：1995-09-01
IPC分类号： C12N15/867 , C12N7/00 , C12N15/11 , A61K48/00
CPC分类号： C12N15/86 , C12N2740/13043
摘要： The present invention relates to a retroviral vector undergoing promoter conversion comprising a 5'LTR region of the structure U3-R-U5; one or more sequences selected from coding and non-coding sequences; and a 3'LTR region comprising a completely or partially deleted U3 region wherein said deleted U3 region is replaced by a polylinker sequence, followed by the R and U5 region. Said retroviral vector undergoes promoter conversion and is useful as a gene transfer vehicle for targeted gene therapy.
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4.发明公开THE USE OF THE WAP OF MMTV REGULATORY SEQUENCES FOR TARGETED EXPRESSION OF LINKED HETEROLOGOUS GENES IN HUMAN MAMMARY CELLS, INCLUDING HUMAN MAMMARY CARCINOMA CELLS 失效在人乳腺癌细胞，包括人BRUSTKARZIONOMZELLEN异源基因的表达或WAP MMTV的调控序列的控制之下
公开(公告)号：EP0848757A1
公开(公告)日：1998-06-24
申请号：EP96931040.0
申请日：1996-09-06
申请人： Bavarian Nordic Research Institute A/S , GSF - Forschungszentrum für Umwelt und Gesundheit, GmbH
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , C12N9/0042 , C12N15/85 , C12N2740/13043 , C12N2800/108 , C12N2830/008 , C12N2830/85 , C12N2840/20
摘要： The present invention relates to the use of the WAP or MMTV regulatory sequences for the targeted expression of linked heterologous DNA sequences in human mammary cells, including human mammary carcinoma cells.
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5.发明公开
公开(公告)号：EP0817858A1
公开(公告)日：1998-01-14
申请号：EP96907398.0
申请日：1996-03-08
CPC分类号： C12N15/86 , A61K48/00 , C07K14/43563 , C07K14/43572 , C12N2740/13043
摘要： The present invention relates to retroviral vectors carrying sequences encoding naturally occuring, antimicrobial peptides or derivatives thereof for the treatment of mammalian tumours, viral infections such as HIV infection and bacterial and fungal infections. In particular the present invention relates to retroviral vectors which undergo promoter conversion (Procon vectors) carrying such sequences. Since these vectors also carry tumour or virus specific regulatory elements, the therapeutic antimicrobial peptide will be delivered and expressed only in relevant, affected cells and not in innocent bystander cells.
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6.发明授权RETROVIRAL VECTORS CARRYING SENESCENT CELL DERIVED INHIBITORS 1 (SDI-1) OR ANTISENSE SDI-1 NUCLEOTIDE SEQUENCES 失效逆转录病毒载体是DNA合成（SDI-1），或反义SDI-1的核苷酸序列的抑制剂CARRY
公开(公告)号：EP0859854B1
公开(公告)日：2002-05-02
申请号：EP96934660.0
申请日：1996-10-11
IPC分类号： C12N15/867 , C07K14/47 , A61K38/17 , C12N15/11
CPC分类号： C12N15/86 , A61K38/00 , C07K14/4703 , C12N2740/13043
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公开(公告)号：EP0892852A2
公开(公告)日：1999-01-27
申请号：EP97919307.0
申请日：1997-03-27
申请人： Bavarian Nordic Research Institute A/S , GSF - Forschungszentrum für Umwelt und Gesundheit, GmbH
CPC分类号： C12N15/86 , A61K48/00 , A61K2035/128 , C12N9/0079 , C12N2740/10043 , C12N2740/16043
摘要： A replication-defective retroviral vector carrying a cytochrome P450 gene under transcriptional control of target cell specific regulatory elements or promoters, or X-ray inducible promoters.
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8.发明公开RETROVIRAL VECTORS CARRYING SENESCENT CELL DERIVED INHIBITORS 1 (SDI-1) OR ANTISENSE SDI-1 NUCLEOTIDE SEQUENCES 失效逆转录病毒载体WEAR DNA合成（SDI-1），或反义SDI-1的核苷酸序列的抑制剂
公开(公告)号：EP0859854A1
公开(公告)日：1998-08-26
申请号：EP96934660.0
申请日：1996-10-11
CPC分类号： C12N15/86 , A61K38/00 , C07K14/4703 , C12N2740/13043
摘要： The present invention relates to retroviral vectors carrying DNA sequences encoding SDI-1, functional analogues or fragments thereof, or antisense SDI-1 DNA sequences, and especially retroviral vectors carrying SDI-1 or antisense SDI-1 sequences under transcriptional control of target cell specific regulatory elements or promoters or X-ray inducible promoters.
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9.发明授权
公开(公告)号：EP0817858B1
公开(公告)日：2003-04-23
申请号：EP96907398.0
申请日：1996-03-08
CPC分类号： C12N15/86 , A61K48/00 , C07K14/43563 , C07K14/43572 , C12N2740/13043
摘要： The present invention relates to retroviral vectors carrying sequences encoding naturally occuring, antimicrobial peptides or derivatives thereof for the treatment of mammalian tumours, viral infections such as HIV infection and bacterial and fungal infections. In particular the present invention relates to retroviral vectors which undergo promoter conversion (Procon vectors) carrying such sequences. Since these vectors also carry tumour or virus specific regulatory elements, the therapeutic antimicrobial peptide will be delivered and expressed only in relevant, affected cells and not in innocent bystander cells.
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10.发明授权THE USE OF THE WAP OF MMTV REGULATORY SEQUENCES FOR TARGETED EXPRESSION OF LINKED HETEROLOGOUS GENES IN HUMAN MAMMARY CELLS, INCLUDING HUMAN MAMMARY CARCINOMA CELLS 失效在人乳腺癌细胞，包括人BRUSTKARZIONOMZELLEN异源基因的表达或WAP MMTV的调控序列的控制之下
公开(公告)号：EP0848757B1
公开(公告)日：2002-03-06
申请号：EP96931040.8
申请日：1996-09-06
IPC分类号： C12N15/867 , A61K48/00 , C12N15/85 , C12N5/10
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , C12N9/0042 , C12N15/85 , C12N2740/13043 , C12N2800/108 , C12N2830/008 , C12N2830/85 , C12N2840/20
摘要： The present invention relates to the use of the WAP or MMTV regulatory sequences for the targeted expression of linked heterologous DNA sequences in human mammary cells, including human mammary carcinoma cells.
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