公开(公告)号：EP1517695A2

公开(公告)日：2005-03-30

申请号：EP03742164.1

申请日：2003-06-24

申请人： Aventis Pharmaceuticals, Inc.

发明人： MERRILL, Jean ,  PU, Su-Fen ,  KHORKOVA, Olga ,  JI, Zhongqi ,  CAMACHO, Fernando ,  BUSCH, Steve ,  WANG, Min ,  CHEN, Ting ,  DINERSTEIN, Robert, J. ,  YAO, Zhengbin ,  CHEN, Yangde ,  ZHANG, Xin ,  CHANDROSS, Karen ,  LEE, Lan

IPC分类号： A61K38/00 ,  A61K39/395 ,  C12Q1/00 ,  C12Q1/70 ,  G01N33/53 ,  G01N33/567

CPC分类号： G01N33/5058 ,  C07K16/24 ,  C12N5/0622 ,  C12N2501/585 ,  G01N33/5029 ,  G01N33/5073 ,  G01N2333/51 ,  G01N2800/285

摘要： Osteopontin is a marker for oligodendrocyte precursor cells. Osteopontin also modulates oligodendrocyte differentiation and central nervous system myelination. Osteopontin induces migration of oligodendrocyte precursors.

公开(公告)号：EP1737440A2

公开(公告)日：2007-01-03

申请号：EP05729215.3

申请日：2005-03-29

申请人： Aventis Pharmaceuticals, Inc.

发明人： CHANDROSS, Karen ,  MERRILL, Jean ,  MINNICH, Anne ,  LEE, Lan ,  KHORKOVA, Olga ,  LIU, Yun

IPC分类号： A61K31/192 ,  A61K31/426 ,  A61P25/02 ,  A61P25/28

CPC分类号： A61K31/426 ,  A61K31/192 ,  A61K2300/00

摘要： A method for treating demyelinating diseases in a patient in need thereof by treatment with an effective amount of a PPAR delta agonist is disclosed. Demyelinating diseases that may be effectively treated by this method include but are not limited to multiple sclerosis, Charcot-Marie-Tooth disease, Pelizaeus-Merzbacher disease, encephalomyelitis, neuromyelitis optica, adrenoleukodystrophy, Guillian-Barre syndrome and disorders in which myelin forming glial cells are damaged including spinal cord injuries, neuropathies and nerve injury.