公开(公告)号：EP1694856A1

公开(公告)日：2006-08-30

申请号：EP04784274.5

申请日：2004-09-15

申请人： Aviva Biosciences Corporation

发明人： WALKER, George, Aviva Biosciences Corporation ,  XU, Junquan, Aviva Biosciences Corporation ,  YAMANISHI, Douglas, Aviva Biosciences Corporation ,  HUJSAK, Paul, Aviva Biosciences Corporation ,  WU, Lei, Aviva Biosciences Corporation ,  HUANG, Mingxian, Aviva Biosciences Corporation ,  TAO, Guoliang, Aviva Biosciences Corporation ,  SNYDER, Sara, Aviva Biosciences Corporation ,  YAP, Charina, Aviva Biosciences Corporation

IPC分类号： C12Q1/02

CPC分类号： B01L3/502761 ,  A61M1/36 ,  A61M1/3618 ,  A61M1/362 ,  A61M1/3679 ,  B01D57/02 ,  B01D61/18 ,  B01D67/0034 ,  B01D67/0062 ,  B01D71/02 ,  B01D71/027 ,  B01D71/04 ,  B01D2325/021 ,  B01D2325/04 ,  B01L3/502 ,  B01L3/502753 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2400/0409 ,  B01L2400/0457 ,  B01L2400/0478 ,  B01L2400/0644 ,  B01L2400/065 ,  G01N1/40 ,  G01N15/0272 ,  G01N15/05 ,  G01N2001/4016 ,  G01N2015/0073 ,  G01N2015/0288 ,  G01N2015/0294 ,  G01N2015/0681

摘要： The invention includes microfabricated filters for filtering fluid samples and methods of enriching rare cells of fluid samples using microfabricated filters of the present invention. The invention also includes solutions for the selective sedimentation of red blood cells (RBCs) from a blood sample and methods of using selective RBC sedimentation solutions for enriching rare cells of a fluid sample. Yet another aspect of the invention is an automated system for processing a fluid sample that includes: at least one filtration chamber that includes a microfabricated filter; automated means for directing fluid flow through at least one filtration chamber of the automated system, and means for collecting enriched rare cells. The present invention also includes methods of using automated systems for separating rare cells from fluid samples.