摘要:
The present invention recognizes that diagnosis and prognosis of many conditions can depend on the enrichment of rare cells from complex fluid sample. In particular, the enrichment of fetal cells from maternal samples, such as maternal blood samples, can greatly aid in the detection of fetal abnormalities or a variety of genetic conditions. In addition, the present invention recognizes that the enrichment of rare malignant cells for patient samples can in diagnosis, prognosis, and development of therapeutic modalities for patients.
摘要:
Improved apparatus for collecting particles from air comprises a cyclone (13) having air inlet (14) and outlet (15) means, means maintaining an airflow there through and means (28) delivering a collecting fluid from a reservoir (26) to particles separated from the air flow in the cyclone (13), in which the air inlet means (14) is associated with means for heating (30) the incoming air. The apparatus, which is optionally provided with enclosure means for trapping heat, prevents freezing of the collecting fluid at temperatures near to and even below 0 grade C.
摘要:
Systems and methods are disclosed that use a nebulizer (106) for remote aerosol generation and then transport the aerosol by way of, for example, an argon gas stream through tubing (154). By transporting the chemical to be analyzed in aerosol form, transport time is reduced from about thirty minutes to less than one minute, using a relatively small amount of sample, and enabling the accurate, remote analysis of a variety of chemicals, including relatively high pH chemicals.
摘要:
The invention includes microfabricated filters for filtering fluid samples and methods of enriching rare cells of fluid samples using microfabricated filters of the present invention. The invention also includes solutions for the selective sedimentation of red blood cells (RBCs) from a blood sample and methods of using selective RBC sedimentation solutions for enriching rare cells of a fluid sample. Yet another aspect of the invention is an automated system for processing a fluid sample that includes: at least one filtration chamber that includes a microfabricated filter; automated means for directing fluid flow through at least one filtration chamber of the automated system, and means for collecting enriched rare cells. The present invention also includes methods of using automated systems for separating rare cells from fluid samples.
摘要:
The invention includes microfabricated filters for filtering fluid samples and methods of enriching rare cells of fluid samples using microfabricated filters of the present invention. The invention also includes solutions for the selective sedimentation of red blood cells (RBCs) from a blood sample and methods of using selective RBC sedimentation solutions for enriching rare cells of a fluid sample. Yet another aspect of the invention is an automated system for processing a fluid sample that includes: at least one filtration chamber that includes a microfabricated filter; automated means for directing fluid flow through at least one filtration chamber of the automated system, and means for collecting enriched rare cells. The present invention also includes methods of using automated systems for separating rare cells from fluid samples.
摘要:
A method and an apparatus for separating fine particles of different fine particle sizes, structures, and functions are provided. The method includes the steps of introducing a group of fine particles of different sizes, structures, and functions into an atmosphere of an adsorption fluid; effecting critical adsorption of the adsorption molecular species to specific sites of the fine particles and, subsequently, separating the fine particles according to size, structure, or function based on one of the masses, the particle diameters, the fluid resistances, and the functions of adsorption abilities to a third substance, which have been changed due to the critical adsorption, or at least two of them in combination.
摘要:
Disclosed herein are aerosol particle growth systems including polymer electrolyte membranes and related methods of increasing the size of aerosol particles. In some embodiments, an outer housing contains a reservoir of a working fluid, and a PEM conduit extends through the outer housing, the reservoir, and the working fluid so that the working fluid is in contact with an outer surface of the PEM conduit. The conduit can be generally helical or coiled, for example. In some embodiments, the working fluid is molecularly transported across the PEM and disperses into an aerosol flowing through the PEM conduit. As the aerosol flows through the PEM conduit, the aerosol particles act as nucleation sites for the gaseous working fluid, which condenses on the particles, causing the particles to grow in size and making them easier to detect, collect, measure, count, study, or otherwise investigate.
摘要:
In a detection apparatus (100A), an inlet (10) and an outlet (11) are opened and an air introducing mechanism (50) is driven to introduce air to a case (5), and airborne particles are electrically attracted and held on a collecting jig 12. After introduction, the inlet and outlet are closed, and amount of fluorescence received by a light receiving element (9) resulting from irradiation with light emitted from a light emitting element (6) is measured by a measuring unit (40). Thereafter, the collecting jig is heated by a heater (91) and the amount of fluorescence after heating is measured by the measuring unit. Based on the amount of change in the amount of fluorescence before and after heating, the amount of microorganisms collected by the collecting jig is calculated at the measuring unit.