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1.发明公开METHODS AND MICROORGANISMS FOR THE PRODUCTION OF 3-(2-HYDROXY-3-METHYL-BUTYRYLAMINO)-PROPIONIC ACID (HMBPA) 审中-公开的方法和微生物为3-（2-羟基-3-甲基 - 丁酰氨基）丙酸THE PRODUCTION（HMBPA）
公开(公告)号：EP1377662A2
公开(公告)日：2004-01-07
申请号：EP02707543.1
申请日：2002-01-19
发明人： HERMANN, Theron , PATTERSON, Thomas, A. , PERO, Janice, G. , ROGERS, R. Yocum , BALDENIUS, Kai-Uwe , BECK, Christine
CPC分类号： C12N9/0008 , C12N9/1022 , C12P7/42 , C12P13/02
摘要： The present invention features methods of producting 3-(2-hydroxy-3-methyl-butyrylamino)-propionic acid ('HMBPA') and α-hydroxyisovalerate ('α-HIV') utilizing microorganisms having modified pantothenate biosynthetic enzyme activities. Recombinant microorganisms and conditions for culturing same are also featured. Also featured are compositions including HMBPA and compositions including α-HIV.
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公开(公告)号：EP1390519B1
公开(公告)日：2006-12-06
申请号：EP02709018.2
申请日：2002-01-18
IPC分类号： C12N9/10 , C12N9/04 , C12P13/02 , C12N15/03 , C07C235/12
CPC分类号： C12N9/0006 , C12N9/1014 , C12N9/1022 , C12N9/88 , C12N9/93 , C12P13/02 , C12Y201/02011 , C12Y401/01011 , C12Y603/02001
摘要： The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
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公开(公告)号：EP1520030A1
公开(公告)日：2005-04-06
申请号：EP02746888.3
申请日：2002-07-03
CPC分类号： C07H21/04 , C12N9/0006 , C12N9/1003 , C12N9/1014 , C12N15/52 , C12P13/02
摘要： The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also featured. Also featured are compositions produced by such microorganisms.
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公开(公告)号：EP1390519A2
公开(公告)日：2004-02-25
申请号：EP02709018.2
申请日：2002-01-18
IPC分类号： C12P13/02 , C12N9/10 , C12N9/04 , C12N15/03 , C07C235/12
CPC分类号： C12N9/0006 , C12N9/1014 , C12N9/1022 , C12N9/88 , C12N9/93 , C12P13/02 , C12Y201/02011 , C12Y401/01011 , C12Y603/02001
摘要： The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
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公开(公告)号：EP1660667A2
公开(公告)日：2006-05-31
申请号：EP03763335.1
申请日：2003-07-03
IPC分类号： C12P1/00
摘要： The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
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公开(公告)号：EP1370670A2
公开(公告)日：2003-12-17
申请号：EP02714764.4
申请日：2002-01-19
发明人： HERMANN, Theron , PATTERSON, Thomas, A. , PERO, Janice, G. , YOCUM, Rogers R. , BALDENIUS, Kai-Uwe , BECK, Christine
CPC分类号： C12P13/04 , C12N9/1022 , C12P13/02
摘要： The present invention features improved methods for producing pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities. In particular, the invention features methods for reducing byproduct formation and increasing yields and purity of desired product. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
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