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公开(公告)号：EP0859786A1
公开(公告)日：1998-08-26
申请号：EP96937291.0
申请日：1996-10-30
发明人： KLING, Andreas , JANSSEN, Bernd , AMBERG, Wilhelm , HAUPT, Andreas , RITTER, Kurt , BUSCHMANN, Ernst , BERNARD, Harald , MÜLLER, Stefan , ZIERKE, Thomas , BARLOZZARI, Teresa , DE ARRUDA, Monika , ROBINSON, Simon
摘要： Novel peptides of the formula A-B-D-E-F-L, wherein A, B, D, E, F, and L have the meanings stated in the specification, and their preparation are disclosed. The novel compounds are suitable for controlling diseases.
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公开(公告)号：EP0758342B1
公开(公告)日：2000-01-05
申请号：EP95917963.1
申请日：1995-04-26
发明人： AMBERG, Wilhelm , BERNARD, Harald , BUSCHMANN, Ernst , HAUPT, Andreas , JANITSCHKE, Lothar , JANSSEN, Bernd , KARL, Ulrich , KLING, Andreas , MÜLLER, Stefan , DE POTZOLLI, Bernd , RITTER, Kurt , THYES, Marco , ZIERKE, Thomas
IPC分类号： C07K7/06
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公开(公告)号：EP0804466A1
公开(公告)日：1997-11-05
申请号：EP95917962.0
申请日：1995-04-26
发明人： AMBERG, Wilhelm , BERNARD, Harald , BUSCHMANN, Ernst , HAUPT, Andreas , JANITSCHKE, Lothar , JANSSEN, Bernd , KARL, Ulrich , KLING, Andreas , MÜLLER, Stefan , DE POTZOLLI, Bernd , RITTER, Kurt , THYES, Marco , ZIERKE, Thomas
摘要： Compounds of formula (I) are disclosed, wherein R?1, R2, R3, and R4¿ have the meanings indicated in the description, as well as a process for the production of these compounds. The compounds are suitable for use as starting material for the synthesis of substances which have anti-tumour properties.
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公开(公告)号：EP1124782A1
公开(公告)日：2001-08-22
申请号：EP99949006.3
申请日：1999-10-16
发明人： BERNARD, Harald , RIECHERS, Hartmut
IPC分类号： C07C51/487 , C07B57/00 , C07C59/48 , C07C59/64
CPC分类号： C07C51/487 , C07B2200/07 , C07C59/48 , C07C59/64
摘要： The invention relates to racemate splitting of 2-hydroxypropionic acids by reacting racemic acid with an optically active base and subsequently separating a diastereomeric salt from the acid and the base. The invention is characterized in that 1-(4-chlorophenyl)ethylamine is used as optically active base.
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公开(公告)号：EP0842190B1
公开(公告)日：1999-10-06
申请号：EP96925744.3
申请日：1996-07-12
发明人： AMBERG, Wilhelm , BERNARD, Harald , BUSCHMANN, Ernst , HAUPT, Andreas , JANSSEN, Bernd , ULRICH, Karl , KLING, Andreas , MÜLLER, Stefan , RITTER, Kurt , ZIERKE, Thomas
CPC分类号： C07K7/06 , C07K5/06165 , C07K5/0808 , C07K5/101
摘要： The description relates to a process for producing pentapeptides of the formula (I) in which A and R -R have the meanings given, in which the pentapeptide is constructed in steps from a prolinamide of the formula (II) in which R and R have the meanings given above, and the group -NR R may be hydrolytically separated from the peptide thus obtained.
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公开(公告)号：EP0866800A2
公开(公告)日：1998-09-30
申请号：EP96943076.0
申请日：1996-12-11
发明人： AMBERG, Wilhelm , BARLOZZARI, Teresa , BERNARD, Harald , BUSCHMANN, Ernst , HAUPT, Andreas , HEGE, Hans-Guenther , JANSSEN, Bernd , KLING, Andreas , LIETZ, Helmut , RITTER, Kurt , ULLRICH, Martina , WEYMANN, Jürgen , ZIERKE, Thomas
CPC分类号： A61K38/08
摘要： Novel peptides of the following formula (I): R1R2N-CHX-CO-A-B-D-E-(G)¿s?-K in which R?1, R2¿, A, B, D, E, G, K, X, and s have the meanings stated in the description, and the preparation thereof are described. The novel peptides have an antineoplastic effect.
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公开(公告)号：EP0804466B1
公开(公告)日：1998-12-02
申请号：EP95917962.3
申请日：1995-04-26
发明人： AMBERG, Wilhelm , BERNARD, Harald , BUSCHMANN, Ernst , HAUPT, Andreas , JANITSCHKE, Lothar , JANSSEN, Bernd , KARL, Ulrich , KLING, Andreas , MÜLLER, Stefan , DE POTZOLLI, Bernd , RITTER, Kurt , THYES, Marco , ZIERKE, Thomas
IPC分类号： C07K5/10
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公开(公告)号：EP0842190A1
公开(公告)日：1998-05-20
申请号：EP96925744.0
申请日：1996-07-12
发明人： AMBERG, Wilhelm , BERNARD, Harald , BUSCHMANN, Ernst , HAUPT, Andreas , JANSSEN, Bernd , ULRICH, Karl , KLING, Andreas , MÜLLER, Stefan , RITTER, Kurt , ZIERKE, Thomas
CPC分类号： C07K7/06 , C07K5/06165 , C07K5/0808 , C07K5/101
摘要： The description relates to a process for producing pentapeptides of the formula (I) in which A and R1-R3 have the meanings given, in which the pentapeptide is constructed in steps from a prolinamide of the formula (II) in which R?1 and R2¿ have the meanings given above, and the group -NR1R2 may be hydrolytically separated from the peptide thus obtained.
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公开(公告)号：EP0758342A1
公开(公告)日：1997-02-19
申请号：EP95917963.0
申请日：1995-04-26
发明人： AMBERG, Wilhelm , BERNARD, Harald , BUSCHMANN, Ernst , HAUPT, Andreas , JANITSCHKE, Lothar , JANSSEN, Bernd , KARL, Ulrich , KLING, Andreas , MÜLLER, Stefan , DE POTZOLLI, Bernd , RITTER, Kurt , THYES, Marco , ZIERKE, Thomas
摘要： Disclosed is the compound Me2Val-Val-MeVal-Pro-Pro-NHBzl. HCl. The compound is produced from Z-Val-Val-MeVal-Pro-OR1, wherein Z and R1 have the meanings indicated in the description. The compound disclosed has anti-neoplastic properties.
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公开(公告)号：EP0570375B1
公开(公告)日：1995-04-19
申请号：EP91920137.6
申请日：1991-11-21
CPC分类号： C07K14/815 , A61K38/00
摘要： The description relates to peptides of the formula (I), in which X, A1-A7, Y and W have the meanings given in the description, and their production. The peptides are suitable for combatting diseases.
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