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公开(公告)号：EP1165601A2
公开(公告)日：2002-01-02
申请号：EP00920661.6
申请日：2000-04-05
发明人： BAUCKE, Dorit , MACK, Helmut , SEITZ, Werner , HORNBERGER, Wilfried , BACKFISCH, Gisela , DELZER, Jürgen
CPC分类号： C07K5/06078 , A61K38/00 , C07B43/00 , C07K5/0222
摘要： The invention relates to prodrugs of pharmacologically active, five-membered heterocyclic amidines from which in vivo compounds are obtained, these compounds being competitive inhibitors of trypsin-type serin proteases, especially thrombin and kininogenases such as kallikrein. The invention also relates to the production of these prodrugs and to their use as medicaments, to pharmaceutical compositions that contain the prodrugs of the active compounds as components, and to the use of the compounds as thrombin inhibitors, anticoagulants and anti-inflammatory agents.
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公开(公告)号：EP0730473B1
公开(公告)日：2001-08-29
申请号：EP95901432.5
申请日：1994-11-25
IPC分类号： A61K47/48
CPC分类号： A61K47/545 , A61K38/00 , A61K47/54
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公开(公告)号：EP1049673A1
公开(公告)日：2000-11-08
申请号：EP99903676.7
申请日：1999-01-23
发明人： BAUCKE, Dorit , LANGE, Udo , MACK, Helmut , SEITZ, Werner , HÖFFKEN, Hans, Wolfgang , HORNBERGER, Wilfried
IPC分类号： C07D205/04 , C07K5/06
CPC分类号： C07D405/12 , C07D409/12 , C07D417/12 , C07K5/0222
摘要： The invention relates to compounds of the formula A-B-D-E-F, in which A, B, D, E and F have the meanings given in the description, and to their production. These new compounds are suitable for producing medicines.
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4.发明公开ANCROD SPEZIFISCHE MONOKLONALE ANTIKÖRPER, ANTIKÖRPERFRAGMENTE, DEREN MISCHUNGEN ODER DERIVATE UND DEREN VERWENDUNG 失效安克洛酶特异性单克隆抗体，抗体片段，它们的混合物或它们的衍生物以及它们的用途
公开(公告)号：EP1000087A2
公开(公告)日：2000-05-17
申请号：EP98936383.3
申请日：1998-06-23
IPC分类号： C07K16/00
CPC分类号： G01N33/573 , A61K38/00 , C07K16/40 , G01N2333/96433
摘要： The invention relates to ancrod specific monoclonal antibodies, antibody fragments, mixtures or derivatives thereof and the use thereof in pharmaceutical preparations or in diagnostics. The invention also relates to cells which express said antibodies, antibody fragments and mixtures or derivatives thereof.
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公开(公告)号：EP0773955A1
公开(公告)日：1997-05-21
申请号：EP95923231.0
申请日：1995-06-06
发明人： BÖHM, Hans-Joachim , KOSER, Stefan , MACK, Helmut , PFEIFFER, Thomas , SEITZ, Werner , HÖFFKEN, Hans, Wolfgang , HORNBERGER, Wilfried
CPC分类号： C07K5/0812 , A61K38/00 , A61K47/64 , C07D205/04 , C07D207/16 , C07D207/48 , C07D211/60 , C07K5/06026 , C07K5/0606 , C07K5/06078 , C07K5/06104 , C07K5/06113
摘要： Compounds having the formula (I) are disclosed, in which the substituents have the meanings given in the description, as well as their salts with physiologically acceptable acids and their stereoisomers, and intermediate products for producing the same. These compounds are useful for treating diseases.
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6.发明公开
公开(公告)号：EP1239877A2
公开(公告)日：2002-09-18
申请号：EP00969396.1
申请日：2000-10-02
IPC分类号： A61K45/06
CPC分类号： C07D263/34 , A61K38/00 , A61K45/06 , C07D239/34 , C07D277/48 , C07D307/68 , C07D333/38 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07K5/0202
摘要： The invention relates to the use of modulators of cytokine mediated signalling pathways in combination with integrin αvβ3 receptor antagonists for the treatment or prevention of diseases, particularly to the use of pharmaceutical composition, comprising a modulator of cytokine mediated signalling pathways and an integrin αvβ3 receptor antagonist, for the treatment or prevention of inflammatory or autoimmune disorders, particularly for the treatment or prevention of rheumatoid arthritis and to the pharmaceutical composition itself.
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公开(公告)号：EP0918792B1
公开(公告)日：2000-09-27
申请号：EP97934552.7
申请日：1997-07-29
发明人： BAUCKE, Dorit , LANGE, Udo , MACK, Helmut , PFEIFFER, Thomas , SEITZ, Werner , ZIERKE, Thomas , HÖFFKEN, Hans, Wolfgang , HORNBERGER, Wilfried
IPC分类号： C07K5/02 , C07D207/22 , C07D211/78 , A61K38/05
CPC分类号： C07K5/0222 , A61K38/00 , C07D207/22 , C07D211/78 , Y02P20/55
摘要： Disclosed are compounds having formula (I) wherein the radicals R, R?1, R2, R3, R4, R5 and R6¿, as well as l, m, and n have the meaning indicated in the description, and the production of said compounds. The new compounds can be used to combat illness. Also described are compounds having formula (II) wherein the radicals R, R?1, R2, R3, R4, R5 and R6¿, as well as l, m, and n have the meaning indicated in claim 1, and compounds having formula (III) wherein l and R have the meaning indicated in claim 1 and Y is an N protective group, or N-terminal protected or unprotected amino acid or represents H.
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公开(公告)号：EP0918792A1
公开(公告)日：1999-06-02
申请号：EP97934552.0
申请日：1997-07-29
发明人： BAUCKE, Dorit , LANGE, Udo , MACK, Helmut , PFEIFFER, Thomas , SEITZ, Werner , ZIERKE, Thomas , HÖFFKEN, Hans, Wolfgang , HORNBERGER, Wilfried
IPC分类号： A61K31 , A61K38 , A61P1 , A61P7 , A61P11 , A61P17 , A61P19 , A61P29 , A61P43 , C07D207 , C07D211 , C07K5
CPC分类号： C07K5/0222 , A61K38/00 , C07D207/22 , C07D211/78 , Y02P20/55
摘要： Disclosed are compounds having formula (I) wherein the radicals R, R?1, R2, R3, R4, R5 and R6¿, as well as l, m, and n have the meaning indicated in the description, and the production of said compounds. The new compounds can be used to combat illness. Also described are compounds having formula (II) wherein the radicals R, R?1, R2, R3, R4, R5 and R6¿, as well as l, m, and n have the meaning indicated in claim 1, and compounds having formula (III) wherein l and R have the meaning indicated in claim 1 and Y is an N protective group, or N-terminal protected or unprotected amino acid or represents H.
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9.发明授权2- 3-(4-AMIDINO-PHENYL)]-PROPIONSÄUREDERIVATE, IHRE HERSTELLUNG UND VERWENDUNG 失效2-，3-（4-脒基苯基）] - 丙酸衍生物，其生产和使用
公开(公告)号：EP0668869B1
公开(公告)日：1998-05-13
申请号：EP92913125.8
申请日：1992-06-23
发明人： MACK, Helmut , PFEIFFER, Thomas , HOEFFKEN, Hans, Wolfgang , BOEHM, Hans-Joachim , HORNBERGER, Wilfried
CPC分类号： C07K5/06139 , A61K38/00 , C07K5/0606 , C07K5/06078
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公开(公告)号：EP0809651A1
公开(公告)日：1997-12-03
申请号：EP96903987.0
申请日：1996-02-06
发明人： SEITZ, Werner , MACK, Helmut , ZIERKE, Thomas , BÖHM, Hans-Joachim , HÖFFKEN, Hans, Wolfgang , KOSER, Stefan , PFEIFFER, Thomas , HORNBERGER, Wilfried
CPC分类号： C07K5/0812 , A61K38/00 , C07K5/06026 , C07K5/06034 , C07K5/0606 , C07K5/06078 , C07K5/06113 , C07K5/06191
摘要： The invention concerns thrombin inhibitors of formula (I), wherein R1, A, B, and D have the meanings given in the description, and intermediate products for the preparation thereof. The compounds of formula (I) are suitable for combating diseases.
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