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1.发明授权SUBSTANCE POUR RESTAURER UNE CO-EXPRESSION ET UNE INTERACTION NORMALES ENTRE LES PROTEINES LOX ET NRAGE 有权SUBSTANZ ZUR WIEDERHERSTELLUNG DER NORMALEN CO-EXPRESSION UND INTEREKTION ZWISCHEN LOX-UND NRAGE-PROTEINEN
公开(公告)号：EP1948128B1
公开(公告)日：2017-03-15
申请号：EP06831309.7
申请日：2006-10-26
申请人： BASF Beauty Care Solutions France SAS , Centre National de la Recherche Scientifique , Université Claude Bernard Lyon I
发明人： BOUEZ, Charbel , GLEYZAL, Claudine , ORLY, Isabelle , ANDRE, Valérie , SOMMER, Pascal , REYMERMIER, Corinne , DAMOUR, Odile , PERRIER, Eric
IPC分类号： A61Q19/08 , A61K36/77 , A61K8/97 , G01N33/68 , G01N33/573 , C12Q1/68 , A61P17/06 , A61P17/00 , A61P35/00 , A61P37/06 , A61K36/48 , A61K36/17 , A61K36/185 , A61K36/54
CPC分类号： A61K8/97 , A61K9/0014 , A61K36/17 , A61K36/185 , A61K36/45 , A61K36/48 , A61K36/54 , A61K36/77 , A61K2800/596 , A61K2800/70 , A61Q19/00 , A61Q19/004 , A61Q19/08 , G01N33/5011 , A61K2300/00
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2.发明公开SUBSTANCE POUR RESTAURER UNE CO-EXPRESSION ET UNE INTERACTION NORMALES ENTRE LES PROTEINES LOX ET NRAGE 有权物质恢复正常的共表达与互动之间LOX和NRAGE蛋白质
公开(公告)号：EP1948128A2
公开(公告)日：2008-07-30
申请号：EP06831309.7
申请日：2006-10-26
申请人： BASF Beauty Care Solutions France SAS , Centre National de la Recherche Scientifique , University Claude Bernard Lyon I
发明人： BOUEZ, Charbel , GLEYZAL, Claudine , ORLY, Isabelle , ANDRE, Valérie , SOMMER, Pascal , REYMERMIER, Corinne , DAMOUR, Odile , PERRIER, Eric
IPC分类号： A61K8/97 , G01N33/68 , G01N33/573 , C12Q1/68 , A61P17/06 , A61P17/00 , A61P35/00 , A61P37/06 , A61K36/48 , A61K36/17 , A61K36/185 , A61K36/54
CPC分类号： A61K8/97 , A61K9/0014 , A61K36/17 , A61K36/185 , A61K36/45 , A61K36/48 , A61K36/54 , A61K36/77 , A61K2800/596 , A61K2800/70 , A61Q19/00 , A61Q19/004 , A61Q19/08 , G01N33/5011 , A61K2300/00
摘要： The invention concerns a substance for restoring normal co-expression and interaction between LOX and NRAGE proteins. In particular, the invention concerns the use of an effective amount of at least one substance modulating the expression and/or the activity of LOX having the sequence ID N°1 and/or modulating the expression and/or the activity of NRAGE having the sequence ID N°2 for making a composition for modulating the interaction between the LOX and NRAGE proteins so as to regulate the balance between the phenomena of proliferating cells, of differentiation and apoptosis, in particular in cases where the interaction between LOX and NRAGE proteins is absent or altered. The invention enables in particular skin aging, lichen planus, a graft-versus-host reaction disease, an eczema, a psoriasis, and a cancer, in particular an epithelial cancer, particularly an epithelial skin cancer, of basocellular type, or of spinocellular type to prevented or treated.
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