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1.发明授权SUBSTANCE POUR RESTAURER UNE CO-EXPRESSION ET UNE INTERACTION NORMALES ENTRE LES PROTEINES LOX ET NRAGE 有权SUBSTANZ ZUR WIEDERHERSTELLUNG DER NORMALEN CO-EXPRESSION UND INTEREKTION ZWISCHEN LOX-UND NRAGE-PROTEINEN
公开(公告)号：EP1948128B1
公开(公告)日：2017-03-15
申请号：EP06831309.7
申请日：2006-10-26
申请人： BASF Beauty Care Solutions France SAS , Centre National de la Recherche Scientifique , Université Claude Bernard Lyon I
发明人： BOUEZ, Charbel , GLEYZAL, Claudine , ORLY, Isabelle , ANDRE, Valérie , SOMMER, Pascal , REYMERMIER, Corinne , DAMOUR, Odile , PERRIER, Eric
IPC分类号： A61Q19/08 , A61K36/77 , A61K8/97 , G01N33/68 , G01N33/573 , C12Q1/68 , A61P17/06 , A61P17/00 , A61P35/00 , A61P37/06 , A61K36/48 , A61K36/17 , A61K36/185 , A61K36/54
CPC分类号： A61K8/97 , A61K9/0014 , A61K36/17 , A61K36/185 , A61K36/45 , A61K36/48 , A61K36/54 , A61K36/77 , A61K2800/596 , A61K2800/70 , A61Q19/00 , A61Q19/004 , A61Q19/08 , G01N33/5011 , A61K2300/00
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2.发明公开SUBSTANCE POUR RESTAURER UNE CO-EXPRESSION ET UNE INTERACTION NORMALES ENTRE LES PROTEINES LOX ET NRAGE 有权物质恢复正常的共表达与互动之间LOX和NRAGE蛋白质
公开(公告)号：EP1948128A2
公开(公告)日：2008-07-30
申请号：EP06831309.7
申请日：2006-10-26
申请人： BASF Beauty Care Solutions France SAS , Centre National de la Recherche Scientifique , University Claude Bernard Lyon I
发明人： BOUEZ, Charbel , GLEYZAL, Claudine , ORLY, Isabelle , ANDRE, Valérie , SOMMER, Pascal , REYMERMIER, Corinne , DAMOUR, Odile , PERRIER, Eric
IPC分类号： A61K8/97 , G01N33/68 , G01N33/573 , C12Q1/68 , A61P17/06 , A61P17/00 , A61P35/00 , A61P37/06 , A61K36/48 , A61K36/17 , A61K36/185 , A61K36/54
CPC分类号： A61K8/97 , A61K9/0014 , A61K36/17 , A61K36/185 , A61K36/45 , A61K36/48 , A61K36/54 , A61K36/77 , A61K2800/596 , A61K2800/70 , A61Q19/00 , A61Q19/004 , A61Q19/08 , G01N33/5011 , A61K2300/00
摘要： The invention concerns a substance for restoring normal co-expression and interaction between LOX and NRAGE proteins. In particular, the invention concerns the use of an effective amount of at least one substance modulating the expression and/or the activity of LOX having the sequence ID N°1 and/or modulating the expression and/or the activity of NRAGE having the sequence ID N°2 for making a composition for modulating the interaction between the LOX and NRAGE proteins so as to regulate the balance between the phenomena of proliferating cells, of differentiation and apoptosis, in particular in cases where the interaction between LOX and NRAGE proteins is absent or altered. The invention enables in particular skin aging, lichen planus, a graft-versus-host reaction disease, an eczema, a psoriasis, and a cancer, in particular an epithelial cancer, particularly an epithelial skin cancer, of basocellular type, or of spinocellular type to prevented or treated.
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3.发明公开MC-1R, MC-2R, AND/OR µ OPIOID RECEPTORS STIMULATION 审中-公开MC-1R-，MC-2R-UND / ODER A OPIOID-REZEPTOR-STIMULATION
公开(公告)号：EP2157966A2
公开(公告)日：2010-03-03
申请号：EP08760698.4
申请日：2008-06-06
发明人： PAIN, Sabine , DEZUTTER, Colette , ANDRE, Valérie , REYMERMIER, Corinne , ORLY, Isabelle , PERRIER, Eric
CPC分类号： A61K36/14 , A61K8/97 , A61K8/99 , A61K31/216 , A61K31/343 , A61K31/437 , A61K36/185 , A61K36/24 , A61K36/28 , A61K36/48 , A61K36/53 , A61K36/736 , A61K36/752 , A61K36/888 , A61K36/90 , A61Q19/08
摘要： The invention concerns active substances modulating the expression of the receptors of the products of the POMC gene (MC-1R, MC-2R, and the µ opioid receptor), and possibly modulating the expression of POMC in cutaneous cells, notably to modulate the proliferation and differentiation of epidermal cells in order to re-epithelial, maintain innervation, irrigate the skin, or restore normal pigmentation, or to fight against aging, or to modulate pigmentation independently or not of cutaneous aging. The invention also concerns a method of screening such active substances.
摘要翻译： 本发明涉及调节POMC基因（MC-1R，MC-2R和μ阿片受体）产物受体表达的活性物质，并且可能调节皮肤细胞中POMC的表达，特别是调节增殖 和表皮细胞的分化，以重新上皮，保持神经支配，刺激皮肤，或恢复正常的色素沉着，或抵抗衰老，或独立调节色素沉着或不是皮肤老化。 本发明还涉及筛选此类活性物质的方法。
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公开(公告)号：EP2370052B1
公开(公告)日：2017-08-23
申请号：EP09775137.4
申请日：2009-11-30
CPC分类号： A61K8/97 , A61Q19/008
摘要： The present invention relates to a novel sebum secretion inhibitor and use thereof for the production of cosmetic and pharmaceutical, notably dermatological, compositions, intended for preventing and/or reducing the secretion of sebum and notably of squalene.
摘要翻译： 本发明涉及一种新型皮脂分泌抑制剂及其用于生产旨在预防和/或减少皮脂分泌，特别是角鲨烯分泌的化妆品和药物，特别是皮肤病学组合物的用途。
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公开(公告)号：EP2370052A1
公开(公告)日：2011-10-05
申请号：EP09775137.4
申请日：2009-11-30
CPC分类号： A61K8/97 , A61Q19/008
摘要： The present invention relates to a novel sebum secretion inhibitor and use thereof for the production of cosmetic and pharmaceutical, notably dermatological, compositions, intended for preventing and/or reducing the secretion of sebum and notably of squalene.
摘要翻译： 本发明涉及一种新颖的皮脂分泌抑制剂及其用于生产用于预防和/或减少皮脂，特别是角鲨烯分泌的化妆品和药物，特别是皮肤病学组合物的用途。
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公开(公告)号：EP2157978A2
公开(公告)日：2010-03-03
申请号：EP08760699.2
申请日：2008-06-06
发明人： PAIN, Sabine , DEZUTTER, Colette , ANDRE, Valérie , REYMERMIER, Corinne , ORLY, Isabelle , PERRIER, Eric
IPC分类号： A61K36/14 , A61K8/97 , A61Q19/08 , A61P17/00 , A61K31/437
CPC分类号： A61K36/14 , A61K8/97 , A61K8/99 , A61K31/216 , A61K31/343 , A61K31/437 , A61K36/185 , A61K36/24 , A61K36/28 , A61K36/48 , A61K36/53 , A61K36/736 , A61K36/752 , A61K36/888 , A61K36/90 , A61Q19/08
摘要： The invention concerns active substances modulating the expression of the receptors of the products of the POMC gene (MC-IR, MC-2R, and the μ opioid receptor), and possibly modulating the expression of POMC in cutaneous cells, notably to modulate the proliferation and differentiation of epidermal cells in order to re-epithelial, maintain innervation, irrigate the skin, or restore normal pigmentation, or to fight against aging, or to modulate pigmentation independently or not of cutaneous aging. The invention also concerns a method of screening such active substances.
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公开(公告)号：EP2157966B1
公开(公告)日：2019-03-13
申请号：EP08760698.4
申请日：2008-06-06
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