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1.发明授权SUBSTANCE POUR RESTAURER UNE CO-EXPRESSION ET UNE INTERACTION NORMALES ENTRE LES PROTEINES LOX ET NRAGE 有权SUBSTANZ ZUR WIEDERHERSTELLUNG DER NORMALEN CO-EXPRESSION UND INTEREKTION ZWISCHEN LOX-UND NRAGE-PROTEINEN
公开(公告)号：EP1948128B1
公开(公告)日：2017-03-15
申请号：EP06831309.7
申请日：2006-10-26
申请人： BASF Beauty Care Solutions France SAS , Centre National de la Recherche Scientifique , Université Claude Bernard Lyon I
发明人： BOUEZ, Charbel , GLEYZAL, Claudine , ORLY, Isabelle , ANDRE, Valérie , SOMMER, Pascal , REYMERMIER, Corinne , DAMOUR, Odile , PERRIER, Eric
IPC分类号： A61Q19/08 , A61K36/77 , A61K8/97 , G01N33/68 , G01N33/573 , C12Q1/68 , A61P17/06 , A61P17/00 , A61P35/00 , A61P37/06 , A61K36/48 , A61K36/17 , A61K36/185 , A61K36/54
CPC分类号： A61K8/97 , A61K9/0014 , A61K36/17 , A61K36/185 , A61K36/45 , A61K36/48 , A61K36/54 , A61K36/77 , A61K2800/596 , A61K2800/70 , A61Q19/00 , A61Q19/004 , A61Q19/08 , G01N33/5011 , A61K2300/00
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公开(公告)号：EP1853695A2
公开(公告)日：2007-11-14
申请号：EP06820794.3
申请日：2006-01-26
申请人： BASF Beauty Care Solutions France SAS , Centre National de la Recherche Scientifique , University Claude Bernard Lyon I
发明人： PERRIER, Eric , DAMOUR, Odile , ANDRE, Valerie
IPC分类号： C12M1/22
摘要： The invention relates to a cell culture device. This cell culture device (100), intended for receiving cells with their culture medium, is characterised in that it contains at least one cell-supporting layer of porous material, this layer being obtained by dehydration of an aqueous gel which is poured directly either into said well bottom (110-111), or into the bottom of a cradle or insert (150) of a size which is adapted for being insertable into the volume of the well. The invention enables a culture to be made which can be automated.
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3.发明公开SUBSTANCE POUR RESTAURER UNE CO-EXPRESSION ET UNE INTERACTION NORMALES ENTRE LES PROTEINES LOX ET NRAGE 有权物质恢复正常的共表达与互动之间LOX和NRAGE蛋白质
公开(公告)号：EP1948128A2
公开(公告)日：2008-07-30
申请号：EP06831309.7
申请日：2006-10-26
申请人： BASF Beauty Care Solutions France SAS , Centre National de la Recherche Scientifique , University Claude Bernard Lyon I
发明人： BOUEZ, Charbel , GLEYZAL, Claudine , ORLY, Isabelle , ANDRE, Valérie , SOMMER, Pascal , REYMERMIER, Corinne , DAMOUR, Odile , PERRIER, Eric
IPC分类号： A61K8/97 , G01N33/68 , G01N33/573 , C12Q1/68 , A61P17/06 , A61P17/00 , A61P35/00 , A61P37/06 , A61K36/48 , A61K36/17 , A61K36/185 , A61K36/54
CPC分类号： A61K8/97 , A61K9/0014 , A61K36/17 , A61K36/185 , A61K36/45 , A61K36/48 , A61K36/54 , A61K36/77 , A61K2800/596 , A61K2800/70 , A61Q19/00 , A61Q19/004 , A61Q19/08 , G01N33/5011 , A61K2300/00
摘要： The invention concerns a substance for restoring normal co-expression and interaction between LOX and NRAGE proteins. In particular, the invention concerns the use of an effective amount of at least one substance modulating the expression and/or the activity of LOX having the sequence ID N°1 and/or modulating the expression and/or the activity of NRAGE having the sequence ID N°2 for making a composition for modulating the interaction between the LOX and NRAGE proteins so as to regulate the balance between the phenomena of proliferating cells, of differentiation and apoptosis, in particular in cases where the interaction between LOX and NRAGE proteins is absent or altered. The invention enables in particular skin aging, lichen planus, a graft-versus-host reaction disease, an eczema, a psoriasis, and a cancer, in particular an epithelial cancer, particularly an epithelial skin cancer, of basocellular type, or of spinocellular type to prevented or treated.
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公开(公告)号：EP2170259B1
公开(公告)日：2018-09-05
申请号：EP08774551.9
申请日：2008-06-30
CPC分类号： A61K8/602 , A61K8/41 , A61K8/494 , A61K8/4953 , A61K8/498 , A61K31/132 , A61K2800/51 , A61Q19/06
摘要： This invention relates to the use of a preparation comprising sulfated oligosaccharides which trap spermine and/or spermidine, as an active slimming ingredient in a cosmetic, pharmaceutical and/or nutraceutical composition. One aspect of the invention is to supply a cosmetic, pharmaceutical or nutriceutical composition with a slimming effect.
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公开(公告)号：EP2157978A2
公开(公告)日：2010-03-03
申请号：EP08760699.2
申请日：2008-06-06
发明人： PAIN, Sabine , DEZUTTER, Colette , ANDRE, Valérie , REYMERMIER, Corinne , ORLY, Isabelle , PERRIER, Eric
IPC分类号： A61K36/14 , A61K8/97 , A61Q19/08 , A61P17/00 , A61K31/437
CPC分类号： A61K36/14 , A61K8/97 , A61K8/99 , A61K31/216 , A61K31/343 , A61K31/437 , A61K36/185 , A61K36/24 , A61K36/28 , A61K36/48 , A61K36/53 , A61K36/736 , A61K36/752 , A61K36/888 , A61K36/90 , A61Q19/08
摘要： The invention concerns active substances modulating the expression of the receptors of the products of the POMC gene (MC-IR, MC-2R, and the μ opioid receptor), and possibly modulating the expression of POMC in cutaneous cells, notably to modulate the proliferation and differentiation of epidermal cells in order to re-epithelial, maintain innervation, irrigate the skin, or restore normal pigmentation, or to fight against aging, or to modulate pigmentation independently or not of cutaneous aging. The invention also concerns a method of screening such active substances.
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公开(公告)号：EP2170358A2
公开(公告)日：2010-04-07
申请号：EP08786013.6
申请日：2008-07-09
IPC分类号： A61K36/00 , A61K31/136 , A61K31/192 , A61K31/353 , A61K31/404 , A61K31/407 , A61K31/60 , A61K8/35 , A61K8/41 , A61K8/44 , A61K8/49 , A61K8/97 , A61P3/10 , A61P17/00 , A61Q19/08 , A23L1/29 , G01N33/68
CPC分类号： G01N33/6803 , A61K8/347 , A61K8/365 , A61K8/368 , A61K8/415 , A61K8/492 , A61K8/498 , A61K8/97 , A61K31/05 , A61K31/136 , A61K31/185 , A61K31/192 , A61K31/353 , A61K31/404 , A61K31/407 , A61K31/60 , A61K36/00 , A61Q19/08 , A61K2300/00
摘要： The invention relates to the use, as active ingredient, of at least one substance that promotes AGE deglycation, for the preparation of a composition, especially for limiting the presence of AGEs in a tissue. The invention relates in particular to the use of such a substance for the preparation of a composition for use in preventing and/or combating the decrease in flexibility and/or plasticity and/or elasticity and/or functionality of a tissue, and/or in preventing and/or combating ageing of a tissue, by promoting AGE deglycation in the tissue, wherein said tissue is preferably the skin, or the tissue wall of a blood vessel or of an organ.
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公开(公告)号：EP2170307A2
公开(公告)日：2010-04-07
申请号：EP08786012.8
申请日：2008-07-09
IPC分类号： A61K31/05 , A61K31/122 , A61K31/353 , A61K31/7004 , A61K36/00 , A61K8/97 , A61K8/41 , A61K8/35 , A61K8/34 , A61P17/00 , A61P3/10 , A61Q19/08 , A23L1/29
CPC分类号： A61Q19/08 , A23L33/105 , A61K8/347 , A61K8/35 , A61K8/355 , A61K8/411 , A61K8/415 , A61K8/498 , A61K8/97 , A61K31/05 , A61K31/122 , A61K31/353 , A61K31/7004 , A61K36/15 , A61K36/45 , A61K36/48 , A61K36/52 , A61K36/70 , A61K36/708 , A61K36/73 , A61K36/734 , A61K36/76 , A61K36/77 , A61K36/889 , A61K36/90
摘要： The present invention relates to the use of an active substance that promotes the inhibition of AGE formation, for the preparation of a composition for preventing and/or combating the decrease in elastic and plastic properties of tissues, and in particular of the skin, for inhibiting AGE formation, or for preventing and/or combating protein glycation at the cutaneous level. The invention also relates to a method of screening for such active substances.
摘要翻译： 本发明涉及促进AGEs形成抑制活性物质的用途，用于制备组合物以预防和/或防止组织，特别是皮肤的弹性和塑性特性降低以抑制 AGEs的形成，或用于预防和/或防治皮肤中蛋白质的糖基化。 本发明还涉及筛选这种活性物质的方法。
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8.发明公开MC-1R, MC-2R, AND/OR µ OPIOID RECEPTORS STIMULATION 审中-公开MC-1R-，MC-2R-UND / ODER A OPIOID-REZEPTOR-STIMULATION
公开(公告)号：EP2157966A2
公开(公告)日：2010-03-03
申请号：EP08760698.4
申请日：2008-06-06
发明人： PAIN, Sabine , DEZUTTER, Colette , ANDRE, Valérie , REYMERMIER, Corinne , ORLY, Isabelle , PERRIER, Eric
CPC分类号： A61K36/14 , A61K8/97 , A61K8/99 , A61K31/216 , A61K31/343 , A61K31/437 , A61K36/185 , A61K36/24 , A61K36/28 , A61K36/48 , A61K36/53 , A61K36/736 , A61K36/752 , A61K36/888 , A61K36/90 , A61Q19/08
摘要： The invention concerns active substances modulating the expression of the receptors of the products of the POMC gene (MC-1R, MC-2R, and the µ opioid receptor), and possibly modulating the expression of POMC in cutaneous cells, notably to modulate the proliferation and differentiation of epidermal cells in order to re-epithelial, maintain innervation, irrigate the skin, or restore normal pigmentation, or to fight against aging, or to modulate pigmentation independently or not of cutaneous aging. The invention also concerns a method of screening such active substances.
摘要翻译： 本发明涉及调节POMC基因（MC-1R，MC-2R和μ阿片受体）产物受体表达的活性物质，并且可能调节皮肤细胞中POMC的表达，特别是调节增殖 和表皮细胞的分化，以重新上皮，保持神经支配，刺激皮肤，或恢复正常的色素沉着，或抵抗衰老，或独立调节色素沉着或不是皮肤老化。 本发明还涉及筛选此类活性物质的方法。
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公开(公告)号：EP2170259A1
公开(公告)日：2010-04-07
申请号：EP08774551.9
申请日：2008-06-30
CPC分类号： A61K8/602 , A61K8/41 , A61K8/494 , A61K8/4953 , A61K8/498 , A61K31/132 , A61K2800/51 , A61Q19/06
摘要： This invention relates to the use of a preparation comprising sulfated oligosaccharides which trap spermine and/or spermidine, as an active slimming ingredient in a cosmetic, pharmaceutical and/or nutraceutical composition. One aspect of the invention is to supply a cosmetic, pharmaceutical or nutriceutical composition with a slimming effect.
摘要翻译： 本发明涉及在化妆品，药物和/或营养组合物中作为活性减肥成分捕获精胺和/或亚精胺的硫酸化寡糖的制剂的用途。 本发明的一个方面是提供具有减肥效果的化妆品，药物或营养组合物。
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公开(公告)号：EP2157966B1
公开(公告)日：2019-03-13
申请号：EP08760698.4
申请日：2008-06-06
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