专利检索 ap:("BASF SE") AND inv:"THYWISSEN, Andreas" 第 1 页

1.

发明公开
METHOD OF PRODUCING PROTEINS IN FILAMENTOUS FUNGI WITH DECREASED CLRI ACTIVITY 审中-公开

公开(公告)号：EP3384003A1

公开(公告)日：2018-10-10

申请号：EP16808598.3

申请日：2016-12-02

申请人： BASF SE

发明人： HAEFNER, Stefan , THYWISSEN, Andreas , HARTMANN, Holger , BOEHMER, Nico

IPC分类号： C12N1/15 , C07K14/37 , C12P21/00 , C12P21/02

CPC分类号： C07K14/37 , C12N1/14 , C12N9/2437 , C12N15/01 , C12N15/80 , C12P19/14 , C12P21/00 , C12P21/02 , C12Q1/34

摘要： The present invention relates to a method of producing a recombinant polypeptide in a filamentous fungus which is genetically modified to decrease or eliminate the activity of cellulase regulator 1 (CLR1) and to express the recombinant polypeptide. The method further relates to a filamentous fungus Myceliophthora thermophila, which is genetically modified to decrease or eliminate the activity of CLR1 and to the use of this filamentous fungus in the production of a recombinant polypeptide.

2.

发明公开
METHOD OF PRODUCING PROTEINS IN FILAMENTOUS FUNGI WITH DECREASED CLR2 ACTIVITY 审中-公开

公开(公告)号：EP3384002A1

公开(公告)日：2018-10-10

申请号：EP16808597.5

申请日：2016-12-02

申请人： BASF SE

发明人： HAEFNER, Stefan , THYWISSEN, Andreas , HARTMANN, Holger , BOEHMER, Nico

IPC分类号： C12N1/14 , C12R1/645 , C12P21/02

CPC分类号： C12P21/02 , C07K14/37 , C12N15/80

摘要： The present invention relates to a method of producing a recombinant polypeptide a filamentous fungus which is genetically modified to decrease or eliminate the activity of cellulase regulator 2 (CLR2) and to express said recombinant polypeptide. The method further relates to a filamentous fungus Myceliophthora thermophila, which is genetically modified to decrease or eliminate the activity of CLR2 and the use of this filamentous fungus in the production of a recombinant polypeptide.