公开(公告)号：EP4408476A1

公开(公告)日：2024-08-07

申请号：EP22800325.7

申请日：2022-09-30

申请人： Unichem Laboratories Ltd

发明人： SATHE, Dhananjay ,  IYAPPAN, Saravanakumar ,  BAKSHI, Gautam ,  PATIL, Ganesh

IPC分类号： A61K47/64 ,  A61P35/00

CPC分类号： A61P35/00 ,  A61K47/6415 ,  A61K38/00 ,  C07K14/37

公开(公告)号：EP3384002A1

公开(公告)日：2018-10-10

申请号：EP16808597.5

申请日：2016-12-02

申请人： BASF SE

发明人： HAEFNER, Stefan ,  THYWISSEN, Andreas ,  HARTMANN, Holger ,  BOEHMER, Nico

IPC分类号： C12N1/14 ,  C12R1/645 ,  C12P21/02

CPC分类号： C12P21/02 ,  C07K14/37 ,  C12N15/80

摘要： The present invention relates to a method of producing a recombinant polypeptide a filamentous fungus which is genetically modified to decrease or eliminate the activity of cellulase regulator 2 (CLR2) and to express said recombinant polypeptide. The method further relates to a filamentous fungus Myceliophthora thermophila, which is genetically modified to decrease or eliminate the activity of CLR2 and the use of this filamentous fungus in the production of a recombinant polypeptide.

公开(公告)号：EP2576792B1

公开(公告)日：2018-08-01

申请号：EP11726858.1

申请日：2011-05-30

申请人： Teknologian tutkimuskeskus VTT Oy

发明人： PAKULA, Tiina ,  SALOHEIMO, Markku ,  HÄKKINEN, Mari ,  WESTERHOLM-PARVINEN, Ann ,  PENTTILÄ, Merja ,  VITIKAINEN, Marika

IPC分类号： C12N15/80

CPC分类号： C12N9/48 ,  C07K14/37 ,  C12N9/00 ,  C12N9/16 ,  C12N9/2402 ,  C12N9/2437 ,  C12N9/244 ,  C12N9/2477 ,  C12N15/80 ,  C12P21/00 ,  C12Y302/01004 ,  C12Y302/01006 ,  C12Y302/01091 ,  Y02P20/52

摘要： The present invention relates to a method for genetically modifying a filamentous fungus host for improved protein production. The method comprises that a filamentous fungus host is genetically modified to overexpress or to be deficient of specific genes. The invention relates also to the modified hosts. Furthermore, the invention relates to a method for improved production or for producing an improved composition of proteins, such as cellulases, hemicellulases, other proteins involved in the degradation of lignocellulosic material, or other proteins, in a filamentous fungus host.

公开(公告)号：EP3302076A1

公开(公告)日：2018-04-11

申请号：EP16730275.1

申请日：2016-06-01

申请人： DSM IP Assets B.V.

发明人： DEKKER, Petrus, Jacobus, Theodorus ,  NOOIJENS, Jeroen, Adrianus, Johannes

IPC分类号： A23C13/08 ,  A23C19/097 ,  A23L3/365 ,  A23L3/37 ,  C07K14/37 ,  C07K14/38 ,  C12N15/80 ,  A23J1/00

CPC分类号： A23C13/085 ,  A23C13/12 ,  A23C19/06 ,  A23C19/0684 ,  A23C19/072 ,  A23C19/0976 ,  A23C2210/30 ,  A23J1/008 ,  A23J1/18 ,  A23L3/365 ,  A23L3/37 ,  A23L3/375 ,  C07K14/37 ,  C07K14/39 ,  C12N9/62 ,  C12N15/815

摘要： The present invention relates to a food product which food product is frozen and thawed before consumption as well as to methods for preparing such a food product. The invention further describes production of an ice structuring protein (ISP) in high amounts.

公开(公告)号：EP3284749A1

公开(公告)日：2018-02-21

申请号：EP16780091.1

申请日：2016-04-13

申请人： The University of Tokyo

发明人： SATO, Moritoshi ,  NIHONGAKI, Yuta

IPC分类号： C07K14/315 ,  C12N9/16 ,  C12N15/09 ,  C12N15/113

CPC分类号： C12N9/22 ,  C07K14/37 ,  C07K14/415 ,  C07K14/4728 ,  C07K2319/00 ,  C07K2319/09 ,  C12N9/90 ,  C12N13/00 ,  C12N15/113 ,  C12N15/63 ,  C12N15/90 ,  C12N15/907 ,  C12N2310/20 ,  C12Y502/01008

摘要： The present invention provides, for example, a set of two polypeptides exhibiting the nuclease activity with dependence on light or in the presence of a drug, in which an N-terminal side fragment and a C-terminal side fragment of a Cas9 protein are bound to each of two polypeptides which form a dimer with dependence on light or in the presence of a drug.

摘要翻译： 例如，本发明提供了一组两种表现出依赖于光的核酸酶活性或存在药物的多肽，其中Cas9蛋白的N端侧片段和C端侧片段结合 到依赖于光或在药物存在下形成二聚体的两种多肽中的每一种。

公开(公告)号：EP3242952A1

公开(公告)日：2017-11-15

申请号：EP16735441.4

申请日：2016-01-08

申请人： University of Cincinnati

发明人： HONG, Christian ,  MATSUURA, Toru

IPC分类号： C12P7/10

CPC分类号： C12P7/10 ,  C07K14/37 ,  C12N9/2437 ,  C12N15/80 ,  C12P19/02 ,  C12P19/14 ,  C12P2203/00 ,  Y02E50/16

摘要： Transgenic strains of Neurospora crassa engineered to comprise a synthetic positive feedback loop for a transcriptional activator of cellulase expression such that cellulase production is amplified are disclosed, along with compositions thereof. The transgenic strains are particularly useful in methods for generating purified cellulases, fermentable sugars, and cellulosic ethanol for the efficient production of biofuel from cellulose-containing biomass and waste.

公开(公告)号：EP2970403B1

公开(公告)日：2017-09-20

申请号：EP14722012.3

申请日：2014-03-12

申请人： E. I. du Pont de Nemours and Company

发明人： BROGLIE, Karen E. ,  RAIRDAN, Gregory J.

IPC分类号： C07K14/37 ,  C12N15/82

CPC分类号： C12N15/8282 ,  C07K14/37 ,  C07K14/375

公开(公告)号：EP2609200B1

公开(公告)日：2017-04-26

申请号：EP11763802.3

申请日：2011-08-25

申请人： Danisco US Inc.

发明人： DODGE, Timothy, C. ,  VIRAG, Aleksandra ,  WARD, Michael

IPC分类号： C12N15/80 ,  C12N1/14 ,  C07K14/37 ,  C12R1/885

CPC分类号： C12N15/80 ,  C07K14/37 ,  C12N1/14 ,  C12N9/2428 ,  C12N9/2434 ,  C12N9/2477 ,  C12Y302/01003

公开(公告)号：EP3080244A1

公开(公告)日：2016-10-19

申请号：EP14827736.1

申请日：2014-12-10

申请人： Technische Universität Wien ,  Oregon State University ,  Academia Sinica

发明人： SCHMOLL, Monika ,  TISCH, Doris ,  SCHUSTER, Andre ,  FREITAG, Michael ,  POMRANING, Kyle ,  WANG, Ting Fang

IPC分类号： C12N1/14 ,  C07K14/37 ,  C12P21/02 ,  C12R1/885

CPC分类号： C12N15/80 ,  C07K14/37 ,  C12N1/14 ,  C12P21/00 ,  C12P21/02 ,  C12R1/885

摘要： The present invention relates to a female fertile variant strain of filamentous fungus derived from a female sterile parental strain which comprises at least one of the six female fertility specific gene alleles or derivatives thereof comprising the functional characteristics of these alleles (FS_4-9).

摘要翻译： 本发明涉及来自雌性不育亲本菌株的丝状真菌的雌性可育变种菌株，其包含六种雌性生育特异性基因等位基因或其衍生物中的至少一种，其包含这些等位基因的功能特征（FS_4-9）。

公开(公告)号：EP3072954A1

公开(公告)日：2016-09-28

申请号：EP14862325.9

申请日：2014-11-14

申请人： Korea Research Institute of Bioscience and Biotechnology

发明人： KIM, Seonghun

IPC分类号： C12N1/14 ,  C07K14/37 ,  C07K14/42

CPC分类号： C07K14/375 ,  C07K14/37 ,  G01N33/582 ,  G01N33/6848 ,  G01N2333/42

摘要： The present invention concerns lectins isolated from the fruiting body of a novel Hericium erinaceum (deposit number: KCTC 12499BP) NEU-1 L strain which bind specifically to sialic acid. The invention further pertains to uses of such lectinsn abd to processes for their preparation thereby. The lectin of the present invention can be useful as an active ingredient of a composition or a kit for measuring or detecting glycoproteins, glycopeptides, glycolipids, sugar precursors or oligosaccharides containing sialic acid moieties, or further for measuring or detecting cell lines, bacteria and viruses containing sialoglycoconjugates.

摘要翻译： 本发明涉及分离自与唾液酸特异性结合的新型猴头菌（保藏号：KCTC 12499BP）NEU-1L菌株的子实体的凝集素。 本发明进一步涉及这种外加剂和由此制备它们的方法的用途。 本发明的凝集素可用作用于测量或检测包含唾液酸部分的糖蛋白，糖肽，糖脂，糖前体或寡糖或进一步用于测量或检测细胞系，细菌和病毒的组合物或试剂盒的活性成分 含有唾液糖结合物。