公开(公告)号：EP1087950A1

公开(公告)日：2001-04-04

申请号：EP99929179.2

申请日：1999-06-11

申请人： BAYER AG

发明人： LENSKY, Stephan ,  RIEDL, Bernd ,  FÜRSTNER, Chantal ,  ERGÜDEN, Jens ,  BÖSS, Frank ,  SCHMIDT, Bernard ,  VAN DER STAAY, Franz-Josef ,  SCHRÖDER, Werner ,  SCHUHMACHER, Joachim ,  SCHMIDT, Delf

IPC分类号： C07D261/12 ,  C07D413/06 ,  A61K31/42

CPC分类号： C07D413/06 ,  C07D261/12

摘要： The invention relates to new 2-aminocarbonyl-5(2H)-isoxazolones used as selective ligands of a high-affinity binding site of diisopropyl-fluorophosphate (DFP) on brain membranes, for prophylaxis and treatment of diseases of the central nervous system, especially cognitive disorders, depression, schizophrenia and anxiety.

公开(公告)号：EP1047685A1

公开(公告)日：2000-11-02

申请号：EP99903604.9

申请日：1999-01-05

申请人： BAYER AG

发明人： STOLLE, Andreas ,  ANTONICEK, Horst-Peter ,  LENSKY, Stephan ,  VOERSTE, Arnd ,  MÜLLER, Thomas ,  BAUMGARTEN, Jörg ,  VON DEM BRUCH, Karsten ,  MÜLLER, Gerhard ,  STROPP, Udo ,  HORVATH, Ervin ,  DE VRY, Jean-Marie-Viktor ,  SCHREIBER, Rudy

IPC分类号： C07D307/93 ,  C07D409/06 ,  A61K31/365 ,  A61K31/38

CPC分类号： C07D307/935 ,  C07D409/06

摘要： The invention relates to novel substituted β,η-anellated lactones, to methods for producing said β,η-anellated lactones, and to their use for preventing and/or treating diseases caused by the hyper- or hypofunction of the glutamatergic system, especially cerebral ischaemia, cranial/cerebral trauma, pain or CNS-mediated cramps.

公开(公告)号：EP0896540A1

公开(公告)日：1999-02-17

申请号：EP97920431.0

申请日：1997-04-17

申请人： Troponwerke GmbH & Co. KG ,  BAYER AG

发明人： MAURER, Fritz ,  SCHMIDT, Bernard ,  LENSKY, Stephan ,  VAN DER STAAY, Franz-Josef ,  FANELLI, Richard, Joseph ,  BRITELLI, David, Ross

IPC分类号： A61K31 ,  A61P25 ,  C07F9

CPC分类号： C07F9/4006

摘要： The present invention relates to the use of phosphonic acid esters for the treatment and prevention of functional disorders of the brain and depression.