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8 条记录 (耗时 0.014 秒)

    BLOOD POOL IMAGING COMPOSITION AND METHOD OF ITS USE
    2.
    发明公开
    BLOOD POOL IMAGING COMPOSITION AND METHOD OF ITS USE 失效
    成分对于Visual申请方式与BLUTGESCHWÜLSTEN的

    公开(公告)号：EP0711178A4

    公开(公告)日：1999-12-08

    申请号：EP94919353

    申请日：1994-06-03

    申请人： GEN HOSPITAL CORP

    发明人： BOGDANOV ALEXEI A ,  WEISSLEDER RALPH ,  BRADY THOMAS J ,  CALLAHAN RONALD

    IPC分类号： A61K51/06 ,  A61K49/00 ,  A61K38/16

    CPC分类号： A61K51/065

    摘要： The invention features a method of blood pool imaging which utilizes an imaging agent which can be easily labelled with a radioactive isotope and injected into a patient. The imaging agent is a covalent conjugate of a polymeric carrier, protective groups, and chelating groups. The imaging agent is preferably provided in the form of a blood pool imaging composition, which includes an imaging agent of the invention, a buffer and a reducing compound. A radioactive isotope is added to the blood pool imaging composition to label the imaging agent, and the composition containing the labelled imaging agent is injected intravenously into a patient.

    IMAGING OF ENZYMATIC ACTIVITY
    4.
    发明公开
    IMAGING OF ENZYMATIC ACTIVITY 审中-公开
    酶活性时图像显示

    公开(公告)号：EP1326523A4

    公开(公告)日：2005-01-05

    申请号：EP01987638

    申请日：2001-10-19

    申请人： GEN HOSPITAL CORP

    发明人： BOGDANOV ALEXEI ,  WEISSLEDER RALPH

    IPC分类号： C12N15/09 ,  C07K5/04 ,  C07K7/04 ,  C12Q1/00 ,  C12Q1/26 ,  C12Q1/34 ,  C12Q1/48 ,  G01R33/465 ,  G01R33/48

    CPC分类号： G01R33/48 ,  G01R33/465

    摘要： The invention features methods of detecting enzymatic activity (e.g., in a magnetic resonance image). The methods include: (I) providing a monomeric substrate (e.g., a substrate that is polymerizable in the presence of an enzyme or as a result of an enzyme-catalyzed reaction), having the generic structure X-Y-Z, where X includes a chelator moiety having a chelated paramagnetic or supermagnetic metal atom or iron, Y includes a linker moiety (e.g., to provide a covalent or non-covalent chemical bond or bonds between X and Z), and Z includes a polymerizing moiety; (2) contacting the substrate with a target tissue, wherein the substrate undergoes polymerization to form a paramagnetic or supermagnetic polymer, the polymerization being catalyzed by an enzyme in an extracellular matrix or bound to the surfaces of cells of the target tissue; and (3) detecting an increase in relativity for the polymer relative to an equivalent amount of unpolymerized substrate. The invention also features substrate compositions. Figure (1) is a synthetic pathway used for synthesis of an enzyme-responsive, paramagnetic monomeric substrate.