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    IMAGE PROCESSING AND ANALYSIS OF ARRAY DATA
    2.
    发明公开
    IMAGE PROCESSING AND ANALYSIS OF ARRAY DATA 有权
    BILDVERARBEITUNG UND ANALYZE DER MATRIXDATEN

    公开(公告)号：EP1769424A2

    公开(公告)日：2007-04-04

    申请号：EP05764118

    申请日：2005-06-28

    申请人： BIOARRAY SOLUTIONS LTD ,  XIA XIONGWU ,  YIPING GUAN

    发明人： XIONGWU XIA ,  YIPPING GUAN

    IPC分类号： G06T7/00 ,  G06K9/32

    CPC分类号： G06K9/3275 ,  G06K2209/07 ,  G06T7/73 ,  G06T2207/30072

    摘要： Disclosed are methods of processing images, and in particular aligning and orienting grids from a fluorescent array of signal sources, by linking nearest neighbor sources to form a hexagon, and then using the hexagon lines for alignment and orientation of the grid. Also disclosed are methods and algorithms for aligning image with grid and correcting for signal beads which are smaller than a grid field and the shift in a grid field. These methods can be used where the signal sources are fluorescent images from a microarray. Also disclosed are methods of automated watershed clustering following transformation.

    摘要翻译： 公开了处理图像的方法，特别是通过链接最近邻源来形成六边形，并且然后使用六边形线来对准和定向网格，从信号源的荧光阵列对准和定向网格。 还公开了用于将图像与网格对齐并校正小于网格场的信号珠和网格场中的偏移的方法和算法。 这些方法可用于信号源是来自微阵列的荧光图像。 还公开了在转化之后的自动分水岭聚类的方法。

    AUTOMATED ANALYSIS OF MULTIPLEXED PROBE-TRAGET INTERACTION PATTERNS: PATTERN MATCHING AND ALLELE IDENTIFICATION
    3.
    发明公开
    AUTOMATED ANALYSIS OF MULTIPLEXED PROBE-TRAGET INTERACTION PATTERNS: PATTERN MATCHING AND ALLELE IDENTIFICATION 有权
    AUTOMATED交互模式分析复用器样品取样目标和比较ALLELIDENTIFIKATION

    公开(公告)号：EP1774323A4

    公开(公告)日：2008-09-03

    申请号：EP05789862

    申请日：2005-08-02

    申请人： BIOARRAY SOLUTIONS LTD

    发明人： XIONGWU XIA ,  SEUL MICHAEL

    IPC分类号： C12Q1/68 ,  G01N33/48

    CPC分类号： C12Q1/6827 ,  G06F19/18 ,  G06F19/22

    摘要： Disclosed are methods and algorithms (and their implementation) supporting the automated analysis and interactive review and refinement ("redaction") of the analysis within an integrated software environment, for automated allele assignments. The implementation, preferably with a software system and a program referred to as the Automated Allele Assignment ("AAA") program, provides a multiplicity of functionalities including: data management by way of an integrated interface to a portal a database to permit visualizing, importing, exporting and creating customizable summery reports; system configuration ("Set-up") including user authorization, training set analysis and probe masking; Pattern Analysis including string matching and probe flipping; and Interactive Redaction combining real-time database computations and "cut-and­paste" editing, generating "warning" statements and supporting annotation. It also includes a thresholding function, a method of setting thresholds, a method of refining thresholds by matching an experimental binary string ("reaction pattern") setting for that probe, probe masking of signals produced by probes which do not contribute significantly to discriminating among alleles.