公开(公告)号：EP1981902A4

公开(公告)日：2009-12-23

申请号：EP07762730

申请日：2007-01-26

申请人： BIOGEN IDEC INC

发明人： LEE DANIEL H S ,  WEN DINGYI ,  PEPINSKY R BLAKE ,  RELTON JANE K ,  WANG XINZHONG ,  LUGOVSKOY ALEXEY ,  MEIER WERNER ,  GARBER ELLEN A ,  SILVIAN LAURA ,  WEINREB PAUL H

IPC分类号： A61K39/395 ,  A61K38/17 ,  C07K14/705 ,  C07K16/28 ,  C12N15/113

CPC分类号： C07K14/705 ,  A01K67/027 ,  A01K67/0275 ,  A01K2217/058 ,  A01K2227/105 ,  A01K2267/0356 ,  A61K38/179 ,  A61K39/3955 ,  A61K48/00 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/2863 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2319/30 ,  C07K2319/32 ,  C07K2319/33 ,  C07K2319/74 ,  C12N15/1136 ,  C12N15/1138 ,  C12N15/8509 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53

公开(公告)号：EP2068887A4

公开(公告)日：2010-11-03

申请号：EP08724452

申请日：2008-01-09

申请人： BIOGEN IDEC INC

发明人： MI SHA ,  PEPINSKY R BLAKE ,  SHAO ZHAOHUI ,  GARBER ELLEN A ,  MIKLASZ STEVEN D

IPC分类号： A61K31/70 ,  A61K38/16 ,  A61K39/395 ,  A61P25/00 ,  C07H21/00 ,  C07K14/00 ,  C07K16/00 ,  C07K16/28 ,  C12N5/20 ,  C12N15/13

CPC分类号： C07K16/2803 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

摘要： Endogenous Sp35 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination. Molecules that block endogenous Sp35 function, such as anti-Sp35 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction. The present disclosure provides antibodies specific for Sp35, and methods of using such antibodies as antagonists of endogenous Sp35 function. The disclosure further provides specific hybridoma and phage library-derived monoclonal antibodies, nucleic acids encoding these antibodies, and vectors and host cells comprising these antibodies. The disclosure further provides methods of promoting oligodendrocyte survival and myelination in a vertebrate, comprising administering to a vertebrate in need of such treatment an effective amount of an anti-Sp35 antibody.

公开(公告)号：EP1423431A4

公开(公告)日：2005-04-27

申请号：EP02728745

申请日：2002-04-12

申请人： BIOGEN IDEC INC

发明人： LYNE PAUL D ,  GARBER ELLEN A ,  SALDANHA JOSE W ,  KARPUSAS MICHAEL

IPC分类号： G01N33/50 ,  A61K39/395 ,  A61K49/16 ,  A61P29/00 ,  A61P37/00 ,  C07H21/04 ,  C07K16/18 ,  C07K16/24 ,  C07K16/28 ,  C07K16/46 ,  C12N20060101 ,  C12N1/00 ,  C12N5/10 ,  C12N5/12 ,  C12N5/20 ,  C12N5/22 ,  C12N9/00 ,  C12N15/07 ,  C12N15/09 ,  C12N15/11 ,  C12N15/13 ,  G01N33/15 ,  G01N33/53 ,  G01N33/543 ,  G01N33/567 ,  G01N33/577 ,  G06F17/00 ,  G06F17/30 ,  H04N9/64 ,  H04N13/02 ,  H04N15/00

CPC分类号： C07K16/2842 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  Y02A90/26

摘要： Antibodies that specifically bind to VLA-1 integrin and methods of using these antibodies to treat immunological disorders in a subject. Also included are crystal structures of complexes formed by VLA-1 antibodies and their ligands, and VLA-1 antagonists and agonists identified by using the structure coordinates of these structures.