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1.发明公开METHODS FOR TREATING PRESSURE INDUCED OPTIC NEUROPATHY, PREVENTING NEURONAL DEGENERATION AND PROMOTING NEURONAL CELL, SURVIVAL VIA ADMINISTRATION OF LINGO-1 ANTAGONISTS AND TRKB AGONISTS 有权方法压力引起眼睛神经病变的处理，和神经末梢的生成，促进神经细胞的存活BY行政LINGO-1拮抗剂和TrkB激动剂预防
公开(公告)号：EP2205071A4
公开(公告)日：2012-05-23
申请号：EP08837617
申请日：2008-10-10
申请人： BIOGEN IDEC INC
发明人： MI SHA
IPC分类号： A01N37/18 , A61K31/00 , A61K38/18 , A61K39/395 , A61P27/06
CPC分类号： A61K39/3955 , A61K9/0048 , A61K31/00 , A61K31/7088 , A61K38/17 , A61K38/185 , A61K2039/505 , C07K14/705 , C07K16/28 , C07K16/2803 , C07K2317/76 , C07K2319/30 , A61K2300/00
摘要： This invention relates to methods for promoting neuronal survival and regeneration using LINGO-1 antagonists and TrkB agonists. Additionally, the invention relates to methods for treating pressure induced optic neuropathies using LINGO-1 antagonists. The invention also relates generally to methods for increasing TrkB activity and inhibiting JNK pathway signaling using a LINGO-1 antagonist.
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公开(公告)号：EP2068887A4
公开(公告)日：2010-11-03
申请号：EP08724452
申请日：2008-01-09
申请人： BIOGEN IDEC INC
发明人： MI SHA , PEPINSKY R BLAKE , SHAO ZHAOHUI , GARBER ELLEN A , MIKLASZ STEVEN D
IPC分类号： A61K31/70 , A61K38/16 , A61K39/395 , A61P25/00 , C07H21/00 , C07K14/00 , C07K16/00 , C07K16/28 , C12N5/20 , C12N15/13
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/18 , C07K2317/21 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Endogenous Sp35 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination. Molecules that block endogenous Sp35 function, such as anti-Sp35 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction. The present disclosure provides antibodies specific for Sp35, and methods of using such antibodies as antagonists of endogenous Sp35 function. The disclosure further provides specific hybridoma and phage library-derived monoclonal antibodies, nucleic acids encoding these antibodies, and vectors and host cells comprising these antibodies. The disclosure further provides methods of promoting oligodendrocyte survival and myelination in a vertebrate, comprising administering to a vertebrate in need of such treatment an effective amount of an anti-Sp35 antibody.
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3.发明公开USE OF LINGO-4 ANTAGONISTS IN THE TREATMENT OF CONDITIONS INVOLVING DEMYELINATION 有权LINGO-4拮抗剂在与脱髓鞘痛苦的治疗中使用
公开(公告)号：EP2217697A4
公开(公告)日：2013-02-20
申请号：EP08848257
申请日：2008-11-10
申请人： BIOGEN IDEC INC
发明人： MI SHA , PEPINSKY R BLAKE , MCCOY JOHN
CPC分类号： A61K38/1709 , A61K31/70 , A61K38/00 , A61K39/3955 , A61K48/00 , C07K14/47 , C07K14/70503 , C07K16/18 , C07K2317/76 , C07K2319/30 , C12N5/0622 , C12N2501/998 , C12N2502/08
摘要： The invention provides methods of treating diseases, disorders or injuries involving demyelination and dysmyelination, including multiple sclerosis, by the administration of a LINGO-4 antagonist.
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公开(公告)号：EP1965827A4
公开(公告)日：2009-12-23
申请号：EP06838776
申请日：2006-12-01
申请人： BIOGEN IDEC INC
发明人： MI SHA , PEPINSKY R BLAKE , MCCOY JOHN
IPC分类号： A61K38/17 , A61K39/395 , C07H21/04
CPC分类号： C07K16/28 , A01K67/0275 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0393 , A61K2039/505 , C07K14/4702 , C07K16/18 , C07K16/2863 , C07K16/32 , C07K16/40 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C12N15/8509
摘要： The invention provides methods of treating diseases, disorders or injuries involving demyelination and dysmyelination, including multiple sclerosis, by the administration of an Sp35 antagonist. Additional methods include methods for inhibiting the binding of the Sp35 polypeptide with the ErbB2 polypeptide and a method for increasing ErbB2 phosphorylation by contacting oligodendrocytes with an effective amount of a composition comprising an Sp35 antagonist of the invention. Further embodiments of the invention include methods of inhibiting the binding of the Sp35 polypeptide with the ErbB2, increasing ErbB2 phosphorylation and promoting oligodendrocyte differentiation comprising contacting oligodendrocyte or oligodendrcoyte progenitor cells with an ErbB2 binding agent.
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公开(公告)号：EP1904104A4
公开(公告)日：2009-12-09
申请号：EP06786428
申请日：2006-07-07
申请人： BIOGEN IDEC INC
发明人： MI SHA , PEPINSKY R BLAKE , SHAO ZHAOHUI , GRAFF CHRISTILYN P
IPC分类号： A61K39/395 , A61P25/00 , C07K16/18 , C07K16/28 , C12N15/113
CPC分类号： A61K47/48538 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/55 , C07K2317/75 , C07K2317/76 , C07K2319/30 , C12N15/1138 , C12N2310/111 , C12N2310/14
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6.发明公开METHODS FOR PROMOTING MYELINATION, NEURONAL SURVIVAL AND OLIGODENDROCYTE DIFFERENTIATION VIA ADMINISTRATION OF SP35 OR TRKA ANTAGONISTS 审中-公开方法，以促进髓鞘形成，神经元的存活和OLIGODENDROZYTENDIFFERENZIERUNG BY管理或SP35-的 TRKA拮抗剂
公开(公告)号：EP2068866A4
公开(公告)日：2010-04-07
申请号：EP07810708
申请日：2007-07-24
申请人： BIOGEN IDEC INC
发明人： MI SHA , JUNG VINCENT
IPC分类号： A61K31/365
CPC分类号： C07K14/71 , C07K14/705 , C07K2319/30
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7.发明公开METHODS FOR PROMOTING NEURITE OUTGROWTH AND SURVIVAL OF DOPAMINERGIC NEURONS 审中-公开程序对轴突生长的神经元多巴胺的推广和生存
公开(公告)号：EP1959979A4
公开(公告)日：2010-01-27
申请号：EP06836888
申请日：2006-11-03
发明人： MI SHA , ISACSON OLE
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , C12N15/113 , C12N15/115
CPC分类号： A61K38/1709 , A61K39/0007 , A61K48/005 , C12N15/1138 , C12N15/115 , C12N2310/11 , C12N2310/14 , C12N2310/16 , C12N2799/027 , C12N2799/06
摘要： The present invention relates generally to methods for promoting regeneration, outgrowth and survival of dopaminergic neurons comprising contacting said dopaminergic neurons with an effective amount of a composition comprising an Sp35 antagonist. Additionally, the invention is related generally to methods of treating various diseases, disorders or injuries associated with dopaminergic neuronal degeneration or death by administration of an Sp35 antagonist.
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公开(公告)号：EP2672823A4
公开(公告)日：2014-08-27
申请号：EP12745253
申请日：2012-02-03
申请人： BIOGEN IDEC INC
发明人： THOMAS JERMAINE , MI SHA , LIN EDWARD YIN-SHIANG , ZHENG GUO ZHU , MA BIN , CALDWELL RICHARD D , GUCKIAN KEVIN , KUMARAVEL GNANASAMBANDAM
IPC分类号： C07D401/06 , A61K31/55 , A61P25/00 , C07D211/34 , C07D211/60 , C07D211/62 , C07D405/12
CPC分类号： A61K31/445 , A61K31/225 , A61K31/4545 , A61K31/4709 , A61K31/498 , A61K31/517 , A61K31/55 , A61K31/695 , A61K38/21 , A61K39/3955 , C07D211/34 , C07D211/60 , C07D211/62 , C07D215/20 , C07D401/06 , C07D405/12 , C07K16/2842
摘要： Compounds of formula (I) or (II) can modulate the activity of SIP receptors. Compounds of formula (I) or (II) can modulate the activity of SIP receptors.
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公开(公告)号：EP1789070A4
公开(公告)日：2008-09-03
申请号：EP05783641
申请日：2005-08-03
申请人： BIOGEN IDEC INC
发明人： MI SHA , BROWNING JEFFREY L
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0356 , A61K38/191 , A61K48/00 , A61K2039/505 , C07K14/70578 , C07K16/2878 , C07K2319/30 , C12N5/0619 , C12N15/8509 , C12N2501/25 , C12N2517/02 , G01N2333/70575
摘要： The invention provides methods of treating diseases, disorders, injuries, or conditions involving modulating neurite outgrowth and/or survival, including CNS disorders, stroke, or spinal injury, by administration of a TAJ antagonist.
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公开(公告)号：EP1776136A4
公开(公告)日：2009-12-09
申请号：EP05764255
申请日：2005-06-24
申请人： BIOGEN IDEC INC
发明人： MI SHA , PEPINSKY R BLAKE , MCCOY JOHN
IPC分类号： A61K38/17 , A61K31/7088 , A61K39/00
CPC分类号： G01N33/6893 , A61K38/17 , A61K38/1709 , C07K2319/30
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