公开(公告)号：EP1981902A4

公开(公告)日：2009-12-23

申请号：EP07762730

申请日：2007-01-26

申请人： BIOGEN IDEC INC

发明人： LEE DANIEL H S ,  WEN DINGYI ,  PEPINSKY R BLAKE ,  RELTON JANE K ,  WANG XINZHONG ,  LUGOVSKOY ALEXEY ,  MEIER WERNER ,  GARBER ELLEN A ,  SILVIAN LAURA ,  WEINREB PAUL H

IPC分类号： A61K39/395 ,  A61K38/17 ,  C07K14/705 ,  C07K16/28 ,  C12N15/113

CPC分类号： C07K14/705 ,  A01K67/027 ,  A01K67/0275 ,  A01K2217/058 ,  A01K2227/105 ,  A01K2267/0356 ,  A61K38/179 ,  A61K39/3955 ,  A61K48/00 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/2863 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2319/30 ,  C07K2319/32 ,  C07K2319/33 ,  C07K2319/74 ,  C12N15/1136 ,  C12N15/1138 ,  C12N15/8509 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53

公开(公告)号：EP1888113A4

公开(公告)日：2009-07-22

申请号：EP06760258

申请日：2006-05-25

申请人： BIOGEN IDEC INC

发明人： BURKLY LINDA C ,  GARBER ELLEN ,  LUGOVSKOY ALEXEY

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P35/00

CPC分类号： C07K16/2875 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/76

公开(公告)号：EP2394163A4

公开(公告)日：2012-08-01

申请号：EP10738871

申请日：2010-02-05

申请人： BIOGEN IDEC INC

发明人： GORELIK LEONID ,  LUGOVSKOY ALEXEY

IPC分类号： G01N33/569

CPC分类号： G01N33/56983 ,  C07K16/081 ,  C07K2317/33 ,  G01N2333/025 ,  G01N2469/20 ,  G01N2800/28 ,  G01N2800/50 ,  G01N2800/52

摘要： Methods and compositions for determining whether a subject is at risk for PML, including subjects being treated with immunosuppressants, by determining whether the subject harbors a JCV variant with reduced binding for sialic acid relative to a normal JCV, are presented. Furthermore, combinations of JCV-VP1 sequence variations that are associated with PML and that can be used as a basis of an assay for identifying subjects susceptible to PML, subjects with PML (e.g., early stage PML), or subjects at risk of developing PML in response to an immunosuppressive treatment are provided.

公开(公告)号：EP2200611A4

公开(公告)日：2010-09-22

申请号：EP08832337

申请日：2008-09-13

申请人： BIOGEN IDEC INC

发明人： GORELIK LEONID ,  BRICKELMAIER MARGOT ,  LUGOVSKOY ALEXEY

IPC分类号： A61K31/47

CPC分类号： A61K31/575 ,  A61K31/196 ,  A61K31/352 ,  A61K31/437 ,  A61K31/44 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/554 ,  A61K31/573 ,  A61K31/58 ,  A61K31/69 ,  A61K31/7048 ,  A61K38/12 ,  A61K39/3955 ,  A61K45/06 ,  A61M1/38 ,  C07K16/2839 ,  A61K2300/00

摘要： The invention relates to compositions, methods, and kits for treating subjects infected by or at risk of infection with a DNA virus (e.g., a JC Virus or a BK virus). Aspects of the invention are useful to prevent or treat DNA virus associated conditions (e.g., PML) in subjects that are immunocompromised. Compositions are provided that inhibit intracellular replication of DNA viruses.