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    FORMULATIONS AND METHODS FOR STABILIZING PCR REAGENTS
    1.
    发明公开
    FORMULATIONS AND METHODS FOR STABILIZING PCR REAGENTS 审中-公开
    VERFAHREN ZUR STABILISIERUNG VON PCR-REAGENZIEN的FORMULIERUNGEN

    公开(公告)号：EP2934572A4

    公开(公告)日：2016-11-23

    申请号：EP13865767

    申请日：2013-12-20

    申请人： BIOMATRICA INC

    发明人： WHITNEY SCOTT E ,  DE LOS RIOS STEPHANIE ,  GHIRMAI SENAIT ,  MULLER ROLF ,  LIBERAL VASCO ,  WILKINSON STEVEN P

    IPC分类号： C12Q1/68 ,  C12N9/12 ,  C12N9/96

    CPC分类号： C12N9/1252 ,  C12N9/1247 ,  C12N9/96 ,  C12Q1/686 ,  C12Y207/07006 ,  C12Y207/07007 ,  C12Q2521/101 ,  C12Q2527/125 ,  C12Q2563/137

    摘要： Described herein are stabilized polymerase compositions comprising a polymerase and an polymerase stabilizing agent, such as a non-detergent zwitterionic stabilizer or a cationic ester disclosed, for use in nucleic acid amplification or nucleic acid sequencing. Compositions are provided for the stabilization of one or more polymerases in a single stabilized liquid formulation. Also disclosed are methods for making and using stabilized polymerase compositions and kits for nucleic acid amplification and sequencing comprising the stabilized polymerase compositions provided.

    摘要翻译： 本文描述了稳定的聚合酶组合物，其包含用于核酸扩增或核酸测序的聚合酶和聚合酶稳定剂，例如所公开的非洗涤剂两性离子稳定剂或阳离子酯。 提供组合物用于在单一稳定的液体制剂中稳定一种或多种聚合酶。 还公开了制备和使用稳定的聚合酶组合物和用于核酸扩增和测序的试剂盒的方法，其包含提供的稳定的聚合酶组合物。

    COMPOSITIONS FOR STABILIZING DNA, RNA AND PROTEINS IN SALIVA AND OTHER BIOLOGICAL SAMPLES DURING SHIPPING AND STORAGE AT AMBIENT TEMPERATURES
    2.
    发明公开
    COMPOSITIONS FOR STABILIZING DNA, RNA AND PROTEINS IN SALIVA AND OTHER BIOLOGICAL SAMPLES DURING SHIPPING AND STORAGE AT AMBIENT TEMPERATURES 有权
    组合物用于稳定DNA，RNA和蛋白质？唾液和其他生物样本在运输过程和贮存在室温下

    公开(公告)号：EP2598661A4

    公开(公告)日：2013-12-04

    申请号：EP11815082

    申请日：2011-07-26

    申请人： BIOMATRICA INC

    发明人： WHITNEY SCOTT E ,  GHIRMAI SENAIT ,  MULLER ROLF

    IPC分类号： C12Q1/68 ,  A01N1/02 ,  C07D229/00 ,  C07D269/02 ,  C07D283/02 ,  G01N33/48

    CPC分类号： C12Q1/6806 ,  A01N1/021 ,  C12Q2527/137

    摘要： Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated saliva samples may be stored without refrigeration for weeks, months or years in a form that permits recovery of intact DNA following the storage period.

    摘要翻译： 组合物和方法是游离缺失盘为基本上液体，凝胶，悬浮液，浆料，半固体和/或生物样品的胶体存储在与输入盘存储游离缺失组合物混合，允许继无需冷藏存储的生物活性的显着恢复。 在某些实施方案中，未分级的唾液样品可以存储无需冷藏数周，数月或数年的形式做了完整DNA的该储藏期间之后允许恢复。