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公开(公告)号：EP3889138A1
公开(公告)日：2021-10-06
申请号：EP19888999.0
申请日：2019-11-27
发明人： FAN, Lei , WANG, Fei , WU, Xiaoquan , XU, Kexin , CHEN, Ke , LUO, Tongchuan , ZHANG, Shaohua , DU, Wu , ZHANG, Chengzhi , HUO, Yongxu , TU, Zhilin , LI, Xinghai , CHEN, Yuanwei
IPC分类号： C07D235/02 , C07D263/52 , C07D269/02 , C07D277/60 , C07D283/02 , A61P35/00 , A61K31/381 , A61K31/4184 , A61K31/428
摘要： Provided are a histone acetylase p300 inhibitor and a use thereof, belonging to the filed of medicinal chemistry technology. A compound represented by formula (I), or a stereochemical isomer thereof, or a solvate thereof, or a pharmaceutically acceptable salt thereof, can inhibit the activity of histone acetylase p300 and inhibit the proliferation activity of a variety of tumor cells.
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公开(公告)号：EP1201659B1
公开(公告)日：2004-05-19
申请号：EP01402707.2
申请日：2001-10-19
申请人： ISOCHEM
IPC分类号： C07D263/44 , C07D269/02
CPC分类号： C07D263/44
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公开(公告)号：EP3131886B1
公开(公告)日：2020-09-09
申请号：EP15718262.7
申请日：2015-04-17
申请人： Exonate Limited
发明人： BATES, David , MORRIS, Jonathan
IPC分类号： C07D309/04 , C07D241/04 , C07D269/02 , C07D271/10 , C07D307/52 , A61P27/02 , A61K31/496 , A61K31/497 , A61K31/506 , A61P35/00 , A61P25/00 , A61P15/00
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4.发明授权COMPOSITIONS FOR STABILIZING DNA, RNA AND PROTEINS IN SALIVA AND OTHER BIOLOGICAL SAMPLES DURING SHIPPING AND STORAGE AT AMBIENT TEMPERATURES 有权在运输和储存环境温度期间稳定唾液和其他生物样品中DNA，RNA和蛋白质的组合物
公开(公告)号：EP2598661B1
公开(公告)日：2017-09-27
申请号：EP11815082.0
申请日：2011-07-26
申请人： Biomatrica, Inc.
IPC分类号： C12Q1/68 , C07D283/02 , C07D269/02 , C07D229/00 , A01N1/02 , G01N33/48
CPC分类号： C12Q1/6806 , A01N1/021 , C12Q2527/137
摘要： Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated saliva samples may be stored without refrigeration for weeks, months or years in a form that permits recovery of intact DNA following the storage period.
摘要翻译： 公开了在与本文公开的储存组合物混合后对生物样品进行基本上液体，凝胶，悬浮，浆液，半固体和/或胶体储存的组合物和方法，其允许在没有冷藏的储存之后大幅恢复生物活性。 在某些实施方案中，未分级的唾液样品可以储存数周，数月或数年而不需冷藏，其形式允许在储存期后回收完整的DNA。
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5.发明公开PIPERAZINE DERIVATIVES FOR TREATING DISORDERS 审中-公开PIPERAZINDERIVATE ZUR BEHANDLUNG VON ERKRANKUNGEN
公开(公告)号：EP3131886A1
公开(公告)日：2017-02-22
申请号：EP15718262.7
申请日：2015-04-17
发明人： BATES, David , MORRIS, Jonathan
IPC分类号： C07D309/04 , C07D241/04 , C07D269/02 , C07D271/10 , C07D307/52 , A61P27/02 , A61K31/496 , A61K31/497 , A61K31/506 , A61P35/00 , A61P25/00 , A61P15/00
摘要： Anti-angiogenic treatments, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of reducing the risk of pre-eclampsia and compounds for use in such methods are described.
摘要翻译： 描述了抗血管生成治疗，高渗透性障碍的治疗，神经病学和神经变性疾病的治疗，疼痛治疗，降低先兆子痫风险的方法和用于这些方法的化合物。
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6.发明公开COMPOSITIONS FOR STABILIZING DNA, RNA AND PROTEINS IN BLOOD AND OTHER BIOLOGICAL SAMPLES DURING SHIPPING AND STORAGE AT AMBIENT TEMPERATURES 有权组合物用于稳定血液和其他生物样品的DNA，RNA和蛋白质在运输和贮存在室温下
公开(公告)号：EP2598660A2
公开(公告)日：2013-06-05
申请号：EP11815081.2
申请日：2011-07-26
申请人： Biomatrica, Inc.
IPC分类号： C12Q1/68 , C07D283/02 , C07D269/02 , C07D229/00 , A01N1/02 , G01N33/48
CPC分类号： A01N1/021 , C12Q1/6806 , C12Q2527/125
摘要： Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated blood or tissue samples may be stored without refrigeration for weeks, months or years in a form that permits recovery of intact DNA, RNA or protein components following the storage period.
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公开(公告)号：EP0357750A4
公开(公告)日：1991-01-30
申请号：EP89903412
申请日：1989-03-03
申请人： BIORESEARCH, INC.
IPC分类号： C07D277/20 , C07D263/16 , C07D263/44 , C07D265/06 , C07D267/06 , C07D269/02 , C07D277/34 , C07D279/06 , C07D281/02 , C07D283/02 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07K1/00 , C07K1/02 , C07K1/04 , C07K1/06 , C07K1/113 , C07K5/06 , C07K5/062 , C07K5/08 , C07K5/083 , C07D211/60 , C07D263/26 , C07D277/04
CPC分类号： C07D263/44 , C07D277/34 , C07K1/023 , C07K1/04
摘要： The invention relates to urethane-protected amino acid-N-carboxyanhydride and N-thiocarboxyanhydride compounds which are useful in peptide, polypeptide, and protein synthesis. Disclosed herein is the preparation and use of these novel compounds.
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公开(公告)号：EP2730564B1
公开(公告)日：2018-04-18
申请号：EP14153493.3
申请日：2011-11-18
发明人： Ho, Koc-kan , Diller, David , Letourneau, Jeffrey J. , McGuinness, Brian F. , Cole, Andrew G. , Rosen, David , Van Oeveren, Cornelis A. , Pickens, Jason C. , Zhi, Lin , Shen, Yixing , Pedram, Bijan
IPC分类号： C07D235/02 , C07D269/02 , C07D277/42 , C07D277/60 , A61K31/407 , A61K31/4168 , A61K31/4353
CPC分类号： C07D513/04 , A61K31/407 , A61K31/4168 , A61K31/4353 , A61P29/00 , A61P37/00 , C07D235/02 , C07D269/02 , C07D277/42 , C07D277/60 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of using heterocycle amines. Some of the disclosed embodiments include heterocycle amines useful to treat inflammatory disorders.
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公开(公告)号：EP2152680B1
公开(公告)日：2015-06-24
申请号：EP08805594.2
申请日：2008-05-22
申请人： SANOFI
发明人： BIGOT, Antony , LAMPILAS, Maxime
IPC分类号： C07D269/02 , C07D269/00 , C07C235/12
CPC分类号： C07D263/44
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10.发明公开COMPOSITIONS FOR STABILIZING DNA, RNA AND PROTEINS IN SALIVA AND OTHER BIOLOGICAL SAMPLES DURING SHIPPING AND STORAGE AT AMBIENT TEMPERATURES 有权组合物用于稳定DNA，RNA和蛋白质？唾液和其他生物样本在运输过程和贮存在室温下
公开(公告)号：EP2598661A4
公开(公告)日：2013-12-04
申请号：EP11815082
申请日：2011-07-26
申请人： BIOMATRICA INC
发明人： WHITNEY SCOTT E , GHIRMAI SENAIT , MULLER ROLF
IPC分类号： C12Q1/68 , A01N1/02 , C07D229/00 , C07D269/02 , C07D283/02 , G01N33/48
CPC分类号： C12Q1/6806 , A01N1/021 , C12Q2527/137
摘要： Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated saliva samples may be stored without refrigeration for weeks, months or years in a form that permits recovery of intact DNA following the storage period.
摘要翻译： 组合物和方法是游离缺失盘为基本上液体，凝胶，悬浮液，浆料，半固体和/或生物样品的胶体存储在与输入盘存储游离缺失组合物混合，允许继无需冷藏存储的生物活性的显着恢复。 在某些实施方案中，未分级的唾液样品可以存储无需冷藏数周，数月或数年的形式做了完整DNA的该储藏期间之后允许恢复。
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