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公开(公告)号：EP2343102A4
公开(公告)日：2012-09-26
申请号：EP10703213
申请日：2010-01-15
申请人： BIOSERENTACH CO LTD
发明人： HONDA KENSHIN , MOTOI MASASHI , TAKADA KANJI
CPC分类号： A61M37/0015 , A61M2037/003 , A61M2037/0046 , A61M2037/0053 , B29C59/02
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2.发明公开
公开(公告)号：EP3235537A4
公开(公告)日：2018-04-18
申请号：EP15869935
申请日：2015-12-14
发明人： YAMADA SHINYA , CHIYAMA MASATERU , AKITA KENSAKU , UENO TAKAKO , IDE YUKO , NAGAI SACHI , AKAO OSANOBU , ONO ICHIRO , TAKADA KANJI
IPC分类号： A61M37/00 , B05B12/12 , B05D1/00 , B29C31/04 , B29C39/24 , B29C65/00 , B29L31/00 , B41J2/04 , B81B1/00
CPC分类号： B29C39/24 , A61M37/00 , A61M37/0015 , A61M2037/0053 , B05B12/122 , B29C65/004 , B29L2031/7544 , B41J2/04 , B81B1/00
摘要： A microneedle patch with which a treatment is reliably completed in a short time when a microneedle is administered into skin or mucous membrane is provided. A microneedle patch (100F) includes a base member (101) and a plurality of microneedles (103g) supported by the base member (101). Each microneedle (103g) includes a top-section layer (104) comprising a biologically active substance to be inserted in dermis (310), and an intermediate layer (106) provided between the top-section layer (104) and the base member (101), having a composition having breaking strength weaker than breaking strength of a composition of the top-section layer (104), and having a thickness of 5 µm and 100 µm inclusive.
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公开(公告)号：EP3117867A4
公开(公告)日：2017-11-08
申请号：EP14885596
申请日：2014-03-12
发明人： TAKADA KANJI , ONO ICHIRO
CPC分类号： A61M37/0015 , A61K9/0014 , A61K38/00 , A61K38/1825 , A61M2037/0023 , A61M2037/0046 , A61M2202/07 , A61M2202/097
摘要： The problem of the invention is to provide a microneedle preparation administration apparatus that prevents overdosing caused by duplicate administration within a treatment range of skin, more reliably administers a prescribed dose of a growth factor at an intended optional depth in the dermis, exhibits an intended effect, and avoids pigmentation side effects. The solution to the problem is a microneedle preparation administration apparatus comprising: a guide tube; a pedestal in which at least a part thereof including a front end surface is housed within the guide tube and slides in length direction; and driving means for driving the pedestal toward a front end part of the guide tube, and microneedle preparations being to be attached to the front end surface of the pedestal, and the microneedle preparations being to be pressed out from a front end part of the guide tube, wherein the microneedle preparation has a first portion having a tip end part and containing an objective substance, and a second portion having a bottom part and not containing the objective substance, and the front end surface of the pedestal is struck on skin at a collision pressure of 30 N to 200 N per 1 cm 2 .
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4.发明公开
公开(公告)号：EP1844763A4
公开(公告)日：2010-08-18
申请号：EP06712623
申请日：2006-01-30
申请人： BIOSERENTACH CO LTD
发明人： TAKADA KANJI
IPC分类号： A61K9/00 , A61K31/375 , A61K31/728 , A61K31/737 , A61K38/00 , A61K38/18 , A61K38/21 , A61K38/38 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/42 , A61K48/00
CPC分类号： A61K9/7007 , A61K9/0021 , A61K31/375 , A61K31/727 , A61K38/21 , A61K38/28 , A61M37/0015 , A61M2037/0046 , A61M2037/0061
摘要： Self-dissolving needle-like or filamentous shape percutaneously absorbable preparations, by which inherently poorly absorbable drugs into the body through the skin is efficiently administered. The preparations are made of at least one material selected from the group consisting of proteins, polysaccharides, polyvinyl alcohols, carboxyvinyl polymers and sodium polyacrylic acids. An active substance contained therein is released in a sustained-release fashion (1) by forming a water-insoluble layer on its surface, (2) by holding the active substance in porous materials, or (3) by imparting a long-acting characteristic to the active substance. The present invention also provides a sheet-like carrier for holding the preparations on at least one of the sides thereof, and a piece of equipment for holding the preparations so as to facilitate the administration of them.
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5.发明公开PHARMACEUTICAL PREPARATION INTEGRATED WITH MICRONEEDLES FOR SKIN TREATMENT 审中-公开用于皮肤处理的MICRONADEL组装配方
公开(公告)号：EP2641614A4
公开(公告)日：2015-11-04
申请号：EP12783484
申请日：2012-06-28
发明人： TAKADA KANJI , ONO ICHIRO
IPC分类号： A61K45/00 , A61K31/713 , A61K38/00 , A61K47/36 , A61M37/00 , A61P17/00 , A61P17/02 , A61P17/14
CPC分类号： A61M37/0015 , A61K9/0021 , A61K9/70 , A61K38/1825 , A61K45/06 , A61M2037/0046
摘要： A problem to be solved of the present invention is to provide a drug formulation and a method of administering an active ingredient which allow the active ingredient to be delivered evenly into the site of action in the skin with high efficiency while ensuring stability of the active ingredient over a long time, and which are easily handled and are less stressful for patients. Mean for solving the problem is a microneedle assembly formulation for skin treatment comprising a platform and a plurality of conical or pyramidal microneedles formed on the platform containing a base composed of a bio-soluble and thread-forming polymer substance and an objective substance retained in the base, wherein the objective substance is a substance effective for prevention or treatment of skin senescence, or treatment of skin scar.
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6.发明公开
公开(公告)号：EP2343101A4
公开(公告)日：2012-09-26
申请号：EP10703212
申请日：2010-01-15
申请人： BIOSERENTACH CO LTD
发明人： MOTOI MASASHI , HONDA KENSHIN , TERADA TOYOHARU , OKADA TATSUYA , SATOUCHI YOSHITOMO , TAKADA KANJI
CPC分类号： A61M37/0015 , A61M2037/003 , A61M2037/0046 , A61M2037/0053 , B29C59/02
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7.发明公开
公开(公告)号：EP2213284A4
公开(公告)日：2012-03-21
申请号：EP08851780
申请日：2008-11-21
申请人： BIOSERENTACH CO LTD
发明人： TAKADA KANJI
IPC分类号： A61K9/70 , A61K8/02 , A61K8/34 , A61K8/36 , A61K8/64 , A61K8/73 , A61K8/81 , A61K31/07 , A61K31/196 , A61K31/375 , A61K31/404 , A61K31/4178 , A61K31/436 , A61K31/496 , A61K31/7048 , A61K31/727 , A61K38/21 , A61K38/28 , A61K39/00 , A61K47/32 , A61K47/34
CPC分类号： A61K31/07 , A61K9/0021 , A61K9/703 , A61K31/196 , A61K31/375 , A61K31/404 , A61K31/4178 , A61K31/436 , A61K31/496 , A61K31/7048 , A61K31/727 , A61K38/21 , A61K47/36 , A61M37/0015 , A61M2037/0053
摘要： It is an objective to provide a microneedle and a microneedle array formed from a self-dissolving base which can realize higher absorption efficiency and a higher pharmacological availability. A preparation 1 for body surface application has two sections divided in the insertion direction, namely, an acral portion 5 and a rear end portion 6. The acral portion 5 is a section including a body surface insertion end 2, and holds a target substance soluble in base. The rear end portion 6 is a section including a pressing end 3, and is formed mainly only from the base. The rear end portion 6 does not hold the target substance. When the preparation 1 for body surface application is inserted into a body surface such as the skin, since the target substance is contained in the acral portion 5, even if part of the rear end side thereof is subsequently not fully inserted into the body surface, high absorption efficiency and high pharmacological effect can be realized where the actual dose of the target substance is not below the desired amount of the drug.
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