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公开(公告)号：EP3099674A1
公开(公告)日：2016-12-07
申请号：EP15704880.2
申请日：2015-01-23
发明人： BENTZIEN, Joerg , BERRY, Angela , BOSANAC, Todd , BURKE, Michael, J. , DISALVO, Darren , MAO, Can , MAO, Wang , SHEN, Yue
IPC分类号： C07D403/10 , C07D401/10 , A61K31/4155 , A61K31/454 , A61P19/02 , A61P29/00
CPC分类号： C07D403/04 , C07D401/04 , C07D401/10 , C07D403/10
摘要： The present invention encompasses compounds of the formula (I) wherein the groups R1, Cy, and Y are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.
摘要翻译： 本发明包括式（I）化合物，其中R1，Cy和Y基团在本文中定义，其适用于治疗与BTK有关的疾病，制备方法，含有化合物的药物制剂及其使用方法 。
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2.发明公开BENZODIOXANES FOR INHIBITING LEUKOTRIENE PRODUCTION 有权BENZODIOXANE ZUR HEMMUNG DER LEUKOTRIENPRODUKTION
公开(公告)号：EP2822942A1
公开(公告)日：2015-01-14
申请号：EP13712002.8
申请日：2013-03-05
发明人： BRUNETTE, Steven, Richard , ABEYWARDANE, Asitha , BURKE, Michael, J. , KAPADIA, Suresh, R. , KIRRANE, Thomas, Martin, Jr. , NETHERTON, Matthew, Russell , RAZAVI, Hossein , RODRIGUEZ, Sonia , SAHA, Anjan , SIBLAY, Robert , SMITH KEENAN, Lana, Louise , TAKAHASHI, Hidenori , TURNER, Michael, Robert , WU, Jiang-Ping , YOUNG, Erick, Richard, Roush , ZHANG, Qiang , ZHANG, Qing , ZINDELL, Renee, M.
IPC分类号： C07D405/14 , A61K31/357 , C07D319/20 , C07D405/10 , C07D405/12 , C07D487/10 , A61P9/00
CPC分类号： C07D491/052 , A61K31/357 , C07D295/096 , C07D295/155 , C07D319/20 , C07D405/10 , C07D405/12 , C07D405/14 , C07D413/10 , C07D417/10 , C07D417/14 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/04 , C07D513/04 , C07D519/00
摘要： The present invention relates to compounds of formula (I) wherein R
1 to R
3 , A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A
4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.摘要翻译： 本发明涉及式（I）的化合物：其中R1至R3，A，X和n如本文所定义。 式（I）化合物可用作白三烯A4水解酶（LTA4H）的抑制剂和治疗LTA4H相关病症。 本发明还涉及包含式（I）化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，以及制备这些化合物的方法。
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公开(公告)号：EP3099674B1
公开(公告)日：2018-10-24
申请号：EP15704880.2
申请日：2015-01-23
发明人： BENTZIEN, Joerg , BERRY, Angela , BOSANAC, Todd , BURKE, Michael, J. , DISALVO, Darren , MAO, Can , MAO, Wang , SHEN, Yue
IPC分类号： C07D403/10 , C07D401/10 , A61K31/4155 , A61K31/454 , A61P19/02 , A61P29/00
CPC分类号： C07D403/04 , C07D401/04 , C07D401/10 , C07D403/10
摘要： The present invention encompasses compounds of the formula (I) wherein the groups R1, Cy, and Y are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.
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4.发明授权
公开(公告)号：EP2970163B1
公开(公告)日：2018-02-28
申请号：EP14719465.8
申请日：2014-03-13
IPC分类号： C07D277/56 , C07D417/04 , C07D487/08 , C07D487/10 , A61K31/426 , A61K31/427 , A61P11/06 , A61P19/02 , A61P29/00 , A61P37/00
CPC分类号： C07D277/56 , C07D417/04 , C07D487/08 , C07D487/10
摘要： The present invention encompasses compounds of the formula (I) wherein the groups ring A and Cy are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.
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公开(公告)号：EP2822942B1
公开(公告)日：2017-05-10
申请号：EP13712002.8
申请日：2013-03-05
发明人： BRUNETTE, Steven, Richard , ABEYWARDANE, Asitha , BURKE, Michael, J. , KAPADIA, Suresh, R. , KIRRANE, Thomas, Martin, Jr. , NETHERTON, Matthew, Russell , RAZAVI, Hossein , RODRIGUEZ, Sonia , SAHA, Anjan , SIBLEY, Robert , SMITH KEENAN, Lana, Louise , TAKAHASHI, Hidenori , TURNER, Michael, Robert , WU, Jiang-Ping , YOUNG, Erick, Richard, Roush , ZHANG, Qiang , ZHANG, Qing , ZINDELL, Renee, M.
IPC分类号： C07D405/14 , A61K31/357 , C07D319/20 , C07D405/10 , C07D405/12 , C07D487/10 , A61P9/00
CPC分类号： C07D491/052 , A61K31/357 , C07D295/096 , C07D295/155 , C07D319/20 , C07D405/10 , C07D405/12 , C07D405/14 , C07D413/10 , C07D417/10 , C07D417/14 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/04 , C07D513/04 , C07D519/00
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公开(公告)号：EP2970163A1
公开(公告)日：2016-01-20
申请号：EP14719465.8
申请日：2014-03-13
IPC分类号： C07D277/56 , C07D417/04 , C07D487/08 , C07D487/10 , A61K31/426 , A61K31/427 , A61P11/06 , A61P19/02 , A61P29/00 , A61P37/00
CPC分类号： C07D277/56 , C07D417/04 , C07D487/08 , C07D487/10
摘要： The present invention encompasses compounds of the formula (I) wherein the groups ring A and Cy are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.
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