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公开(公告)号：EP2220046A1
公开(公告)日：2010-08-25
申请号：EP08800314.0
申请日：2008-09-11
发明人： TSANTRIZOS, Youla, S. , BAILEY, Murray, D. , BILODEAU, François , CARSON, Rebekah, J. , COULOMBE, René , FADER, Lee , HALMOS, Teddy , KAWAI, Stephen , LANDRY, Serge , LAPLANTE, Steven , MORIN, Sébastien , PARISIEN, Mathieu , POUPART, Marc-André , SIMONEAU, Bruno
IPC分类号： C07D215/14 , A61K31/47 , A61K31/4709 , A61K31/538 , A61P31/18 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D491/06
CPC分类号： C07D215/14 , A61K31/47 , A61K31/4709 , A61K31/473 , A61K31/4741 , A61K31/538 , A61K31/5383 , C07D215/18 , C07D221/16 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D491/06 , C07D498/06
摘要： Compounds of formula (I): wherein R4, R6 and R7 are defined herein, are useful as inhibitors of HIV replication.
摘要翻译： 式（I）化合物：其中R 4，R 6和R 7如本文所定义，可用作HIV复制的抑制剂。
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公开(公告)号：EP1625154B1
公开(公告)日：2014-01-08
申请号：EP04731118.8
申请日：2004-05-05
发明人： COULOMBE, René , BEAULIEU, Pierre, Louis , JOLICOEUR, Eric , KUKOLJ, George , LAPLANTE, Steven , POUPART, Marc-André
CPC分类号： C07K14/005 , C07K2299/00 , C12N9/127 , C12N2770/24222
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公开(公告)号：EP2220076B1
公开(公告)日：2012-01-18
申请号：EP08848765.7
申请日：2008-11-03
发明人： TSANTRIZOS, Youla S. , BAILEY, Murray D. , BILODEAU, François , CARSON, Rebekah J. , FADER, Lee , HALMOS, Teddy , KAWAI, Stephen , LANDRY, Serge , LAPLANTE, Steven , SIMONEAU, Bruno
IPC分类号： C07D413/04 , A61K31/47 , A61K31/4709 , A61K31/538 , A61P31/18 , C07D215/02 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/06
CPC分类号： C07D413/14 , C07D215/14 , C07D215/18 , C07D215/20 , C07D215/38 , C07D215/48 , C07D401/04 , C07D405/04 , C07D405/14 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/12 , C07D417/14 , C07D491/04
摘要： Compounds of formula I : wherein c, R2, R3, R4, R5, R6, R7 and R8 are defined herein, are useful as inhibitors of HIV replication.
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公开(公告)号：EP1625154A1
公开(公告)日：2006-02-15
申请号：EP04731118.8
申请日：2004-05-05
发明人： COULOMBE, René , BEAULIEU, Pierre, Louis , JOLICOEUR, Eric , KUKOLJ, George , LAPLANTE, Steven , POUPART, Marc-André
CPC分类号： C07K14/005 , C07K2299/00 , C12N9/127 , C12N2770/24222
摘要： The HCV NS5B polymerase, when complexed with certain inhibitors, adopts a confirmation in which the finger loop region defined by amino acid residues 18 to 35 is displaced to expose a binding pocket defined generally by amino acid residues 392, 393, 395, 396, 399, 424, 425, 428, 429, 492, 493, 494, 495, 496, 500 and 503. This newly exposed binding pocket defines a novel target in the search of further chemical entities which are capable of binding to HCV NS5B and modulating, or preferably inhibiting, the polymerase activity of HCV NS5B.
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公开(公告)号：EP2429993B1
公开(公告)日：2015-01-21
申请号：EP10774456.7
申请日：2010-05-13
发明人： YOAKIM, Christiane , BAILEY, Murray, D . , BILODEAU, Francois , CARSON, Rebekah, J . , FADER , Lee , KAWAI, Stephen , LAPLANTE, Steven , SIMONEAU, Bruno , SURPRENANT, Simon , THIBEAULT , Carl , TSANTRIZOS, Youla, S . , MORIN, Sebastien
IPC分类号： C07D213/55 , A61K31/44 , A61K31/5375 , A61K31/54 , A61P31/18 , C07D213/60 , C07D401/00 , C07D405/00 , C07D413/00 , C07D417/00 , C07D471/04 , C07D491/06 , C07D498/06
CPC分类号： C07D213/81 , A61K31/4375 , A61K31/44 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/4741 , A61K31/501 , A61K31/506 , A61K31/538 , A61K31/5383 , A61K45/06 , C07D213/55 , C07D401/12 , C07D405/10 , C07D405/14 , C07D411/10 , C07D413/10 , C07D413/14 , C07D417/10 , C07D471/04 , C07D491/06 , C07D498/06
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公开(公告)号：EP2220076A1
公开(公告)日：2010-08-25
申请号：EP08848765.7
申请日：2008-11-03
发明人： TSANTRIZOS, Youla S. , BAILEY, Murray D. , BILODEAU, François , CARSON, Rebekah J. , FADER, Lee , HALMOS, Teddy , KAWAI, Stephen , LANDRY, Serge , LAPLANTE, Steven , SIMONEAU, Bruno
IPC分类号： C07D413/04 , A61K31/47 , A61K31/4709 , A61K31/538 , A61P31/18 , C07D215/02 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/06
CPC分类号： C07D413/14 , C07D215/14 , C07D215/18 , C07D215/20 , C07D215/38 , C07D215/48 , C07D401/04 , C07D405/04 , C07D405/14 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/12 , C07D417/14 , C07D491/04
摘要： Compounds of formula I : wherein c, R2, R3, R4, R5, R6, R7 and R8 are defined herein, are useful as inhibitors of HIV replication.
摘要翻译： 式I化合物：其中c，R2，R3，R4，R5，R6，R7和R8如本文所定义，可用作HIV复制的抑制剂。
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