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1.发明授权ACYLSULFONAMIDE COMPOUNDS AS INHIBITORS OF RNA-DEPENDENT RNA (VIRAL) POLYMERASES 有权酰基磺酰胺化合物作为RNA依赖的RNA聚合酶的抑制剂
公开(公告)号：EP1587585B1
公开(公告)日：2008-10-15
申请号：EP04703128.1
申请日：2004-01-19
IPC分类号： A61P31/14 , C07D401/04 , C07D405/04 , C07D403/04 , C07D409/04 , A61K31/404 , A61K31/4184 , A61K31/343 , A61K31/381
CPC分类号： C07D401/04 , C07D209/08 , C07D403/04 , C07D405/04 , C07D407/04 , C07D409/04
摘要： An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula (I) wherein A, B, R2, R3, M1, M2, M3, M4, Y1 and Z are as defined in claim 1, or a salt thereof, as an inhibitor of HCV NS5B polymerase.
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2.发明公开ACYLSULFONAMIDE COMPOUNDS AS INHIBITORS OF RNA-DEPENDENT RNA (VIRAL) POLYMERASES 有权酰基磺酰胺化合物作为RNA依赖的RNA聚合酶的抑制剂
公开(公告)号：EP1587585A1
公开(公告)日：2005-10-26
申请号：EP04703128.1
申请日：2004-01-19
IPC分类号： A61P31/14 , C07D401/04 , C07D405/04 , C07D403/04 , C07D409/04 , A61K31/404 , A61K31/4184 , A61K31/343 , A61K31/381
CPC分类号： C07D401/04 , C07D209/08 , C07D403/04 , C07D405/04 , C07D407/04 , C07D409/04
摘要： An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula (I) wherein A, B, R2, R3, M1, M2, M3, M4, Y1 and Z are as defined in claim 1, or a salt thereof, as an inhibitor of HCV NS5B polymerase.
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公开(公告)号：EP1625154B1
公开(公告)日：2014-01-08
申请号：EP04731118.8
申请日：2004-05-05
发明人： COULOMBE, René , BEAULIEU, Pierre, Louis , JOLICOEUR, Eric , KUKOLJ, George , LAPLANTE, Steven , POUPART, Marc-André
CPC分类号： C07K14/005 , C07K2299/00 , C12N9/127 , C12N2770/24222
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公开(公告)号：EP1625154A1
公开(公告)日：2006-02-15
申请号：EP04731118.8
申请日：2004-05-05
发明人： COULOMBE, René , BEAULIEU, Pierre, Louis , JOLICOEUR, Eric , KUKOLJ, George , LAPLANTE, Steven , POUPART, Marc-André
CPC分类号： C07K14/005 , C07K2299/00 , C12N9/127 , C12N2770/24222
摘要： The HCV NS5B polymerase, when complexed with certain inhibitors, adopts a confirmation in which the finger loop region defined by amino acid residues 18 to 35 is displaced to expose a binding pocket defined generally by amino acid residues 392, 393, 395, 396, 399, 424, 425, 428, 429, 492, 493, 494, 495, 496, 500 and 503. This newly exposed binding pocket defines a novel target in the search of further chemical entities which are capable of binding to HCV NS5B and modulating, or preferably inhibiting, the polymerase activity of HCV NS5B.
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