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公开(公告)号：EP1625154B1
公开(公告)日：2014-01-08
申请号：EP04731118.8
申请日：2004-05-05
发明人： COULOMBE, René , BEAULIEU, Pierre, Louis , JOLICOEUR, Eric , KUKOLJ, George , LAPLANTE, Steven , POUPART, Marc-André
CPC分类号： C07K14/005 , C07K2299/00 , C12N9/127 , C12N2770/24222
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公开(公告)号：EP1587787A1
公开(公告)日：2005-10-26
申请号：EP04703130.7
申请日：2004-01-19
发明人： BEAULIEU, Pierre Louis , BROCHU, Christian , CHABOT, Catherine , JOLICOEUR, Eric , KAWAI, Stephen , POUPART, Marc-André , TSANTRIZOS, Youla S.
IPC分类号： C07D209/08 , C07D405/04 , C07D405/14 , C07D401/06 , C07D409/04 , C07D409/14 , C07D401/14 , C07D417/14 , C07D401/04 , C07D413/14 , C07D513/04 , C07D209/30 , A61K31/404 , A61P31/12
CPC分类号： C07D401/04 , C07D209/08 , C07D209/30 , C07D401/06 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07D513/04
摘要： An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula (I): wherein wherein A, B, R2, R3, L, M1, M2, M3, M4, Y1, Y0, Z and Sp are as defined in claim 1, or a salt thereof, as an inhibitor of HCV NS5B polymerase.
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公开(公告)号：EP2914588A1
公开(公告)日：2015-09-09
申请号：EP13792793.5
申请日：2013-10-31
发明人： THIBEAULT, Carl , RANCOURT, Jean , BEAULIEU, Pierre L. , DECOR, Anne , GRAND-MAITRE, Chantal , KUHN, Cyrille , VILLEMURE, Elisia , LEBLANC, Melissa , LACOSTE, Jean-Eric , MOREAU, Benoit , JOLICOEUR, Eric , SURPRENANT, Simon , HUCKE, Oliver
IPC分类号： C07D401/14 , C07D403/08 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/10 , C07D491/107 , A61P31/22 , A61K31/404 , A61K31/407 , A61K31/421 , A61K31/4178 , A61K31/4439 , A61K31/4196 , A61K31/497
CPC分类号： C07D491/107 , C07D401/14 , C07D403/06 , C07D403/08 , C07D403/14 , C07D413/14 , C07D471/04 , C07D471/10 , C07D487/10
摘要： Compounds of Formula (I) wherein R
1 , R
2 , R
3A , R
3B , Y, Z
1 and Z
2 are defined herein, are useful for the treatment of cytomegalovirus disease and/or infection.-
公开(公告)号：EP1625154A1
公开(公告)日：2006-02-15
申请号：EP04731118.8
申请日：2004-05-05
发明人： COULOMBE, René , BEAULIEU, Pierre, Louis , JOLICOEUR, Eric , KUKOLJ, George , LAPLANTE, Steven , POUPART, Marc-André
CPC分类号： C07K14/005 , C07K2299/00 , C12N9/127 , C12N2770/24222
摘要： The HCV NS5B polymerase, when complexed with certain inhibitors, adopts a confirmation in which the finger loop region defined by amino acid residues 18 to 35 is displaced to expose a binding pocket defined generally by amino acid residues 392, 393, 395, 396, 399, 424, 425, 428, 429, 492, 493, 494, 495, 496, 500 and 503. This newly exposed binding pocket defines a novel target in the search of further chemical entities which are capable of binding to HCV NS5B and modulating, or preferably inhibiting, the polymerase activity of HCV NS5B.
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公开(公告)号：EP2914588B1
公开(公告)日：2016-09-14
申请号：EP13792793.5
申请日：2013-10-31
发明人： THIBEAULT, Carl , RANCOURT, Jean , BEAULIEU, Pierre L. , DÉCOR, Anne , GRAND-MAITRE, Chantal , KUHN, Cyrille , VILLEMURE, Elisia , LEBLANC, Melissa , LACOSTE, Jean-Eric , MOREAU, Benoit , JOLICOEUR, Eric , SURPRENANT, Simon , HUCKE, Oliver
IPC分类号： C07D401/14 , C07D403/08 , C07D403/14 , C07D413/14 , C07D471/04 , C07D487/10 , C07D491/107 , A61P31/22 , A61K31/404 , A61K31/407 , A61K31/421 , A61K31/4178 , A61K31/4439 , A61K31/4196 , A61K31/497
CPC分类号： C07D491/107 , C07D401/14 , C07D403/06 , C07D403/08 , C07D403/14 , C07D413/14 , C07D471/04 , C07D471/10 , C07D487/10
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