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公开(公告)号：EP0871619B1
公开(公告)日：2002-11-06
申请号：EP96945567.4
申请日：1996-12-04
发明人： CRUTE, James, J. , FAUCHE, Anne-Marie , GRYGON, Christopher, A. , HARGRAVE, Karl, D. , SIMONEAU, Bruno , THAVONEKHAM, Bounkham
IPC分类号： C07D277/40 , A61K31/425 , C07D417/12 , C07D417/14 , C07D277/28 , C07D277/30 , C07D277/24
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/28 , C07D277/40 , C07D277/42 , C07D277/46 , C07D277/48 , C07D417/12 , C07D417/14
摘要： This invention relates to methods for inhibiting herpes replication and for treating herpes infection in a mammal by inhibiting the herpes helicase-primase enzyme complex. This invention also relates to thiazolylphenyl derivatives of formula (G) that inhibit the herpes helicase-primase and to pharmaceutical compositions comprising the thiazolylphenyl derivatives, to methods of using and methods of producing the thiazolylphenyl derivatives. In formula (G), R and Z are as defined in the application where Z is the characterising feature.
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公开(公告)号：EP0871619A1
公开(公告)日：1998-10-21
申请号：EP96945567.0
申请日：1996-12-04
发明人： CRUTE, James, J. , FAUCHE, Anne-Marie , GRYGON, Christopher, A. , HARGRAVE, Karl, D. , SIMONEAU, Bruno , THAVONEKHAM, Bounkham
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/28 , C07D277/40 , C07D277/42 , C07D277/46 , C07D277/48 , C07D417/12 , C07D417/14
摘要： This invention relates to methods for inhibiting herpes replication and for treating herpes infection in a mammal by inhibiting the herpes helicase-primase enzyme complex. This invention also relates to thiazolylphenyl derivatives of formula (G) that inhibit the herpes helicase-primase and to pharmaceutical compositions comprising the thiazolylphenyl derivatives, to methods of using and methods of producing the thiazolylphenyl derivatives. In formula (G), R and Z are as defined in the application where Z is the characterising feature.
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