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    Use of a PCV2 immunogenic composition for lessening clinical symptoms in pigs
    1.
    发明公开
    Use of a PCV2 immunogenic composition for lessening clinical symptoms in pigs 审中-公开
    使用PCV2免疫原性组合物减轻猪的临床症状

    公开(公告)号：EP2374476A1

    公开(公告)日：2011-10-12

    申请号：EP11164856.4

    申请日：2006-12-28

    申请人： BOEHRINGER INGELHEIM VETMEDICA, INC.

    发明人： Roof, Michael B. ,  Hayes, Phillip Wayne ,  Eichmeyer, Marc ,  Nitzel, Greg ,  Schaeffer, Merrill

    IPC分类号： A61K39/12

    CPC分类号： A61K39/12 ,  A61K2039/5252 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/55566 ,  C12N7/00 ,  C12N2750/10022 ,  C12N2750/10023 ,  C12N2750/10034 ,  C12N2750/10051 ,  C12N2750/10071 ,  C12N2750/14143

    摘要： The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.

    摘要翻译： 本发明涉及包含猪圆环病毒2型（PCV2）抗原的免疫原性组合物用于治疗几种临床表现（疾病）的用途。 优选地，临床表现与PCV2感染有关。 优选地，它们包括淋巴结病，淋巴耗竭和/或多核/巨组织细胞。 此外，临床症状包括淋巴结病和猪中的一种或多种以下症状：（1）伴有小叶间水肿的间质性肺炎，（2）皮肤苍白或黄疸，（3）斑驳萎缩肝，（4）胃溃疡 ，（5）肾炎和（6）生殖障碍，例如 流产，死胎，木乃伊等。此外，临床症状包括Pia类病变，通常已知其与细胞内劳索尼亚菌感染相关。