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1.发明公开Use of a PCV2 immunogenic composition for lessening clinical symptoms in pigs 审中-公开使用PCV2免疫原性组合物减轻猪的临床症状
公开(公告)号：EP2374476A1
公开(公告)日：2011-10-12
申请号：EP11164856.4
申请日：2006-12-28
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/5258 , A61K2039/545 , A61K2039/552 , A61K2039/55516 , A61K2039/55555 , A61K2039/55566 , C12N7/00 , C12N2750/10022 , C12N2750/10023 , C12N2750/10034 , C12N2750/10051 , C12N2750/10071 , C12N2750/14143
摘要： The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.
摘要翻译： 本发明涉及包含猪圆环病毒2型（PCV2）抗原的免疫原性组合物用于治疗几种临床表现（疾病）的用途。 优选地，临床表现与PCV2感染有关。 优选地，它们包括淋巴结病，淋巴耗竭和/或多核/巨组织细胞。 此外，临床症状包括淋巴结病和猪中的一种或多种以下症状：（1）伴有小叶间水肿的间质性肺炎，（2）皮肤苍白或黄疸，（3）斑驳萎缩肝，（4）胃溃疡 ，（5）肾炎和（6）生殖障碍，例如 流产，死胎，木乃伊等。此外，临床症状包括Pia类病变，通常已知其与细胞内劳索尼亚菌感染相关。
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公开(公告)号：EP2275130A2
公开(公告)日：2011-01-19
申请号：EP10174456.3
申请日：2006-12-28
发明人： Roof, Michael B. , Eichmeyer, Marc Allan , Nitzel, Greg , Hayes, Phillip Wayne , Schaeffer, Merrill Lynn
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/5258 , A61K2039/545 , A61K2039/552 , A61K2039/55516 , A61K2039/55555 , A61K2039/55566 , C12N7/00 , C12N2750/10022 , C12N2750/10023 , C12N2750/10034 , C12N2750/10051 , C12N2750/10071 , C12N2750/14143
摘要： The present invention relates to an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.
摘要翻译： 本发明涉及包含用于治疗几种临床表现（疾病）的2型猪圆环病毒（PCV2）抗原的免疫原性组合物。 优选地，临床表现与PCV2感染有关。 优选地，它们包括淋巴结病，淋巴耗竭和/或多核/巨组织细胞。 此外，临床症状包括淋巴结病和猪中的一种或多种以下症状：（1）伴有小叶间水肿的间质性肺炎，（2）皮肤苍白或黄疸，（3）斑驳萎缩肝，（4）胃溃疡 ，（5）肾炎和（6）生殖障碍，例如 流产，死胎，木乃伊等。此外，临床症状包括Pia类病变，通常已知其与细胞内劳索尼亚菌感染相关。
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公开(公告)号：EP2371385A1
公开(公告)日：2011-10-05
申请号：EP11164854.9
申请日：2006-12-28
发明人： Roof, Michael B. , Eichmeyer, Marc Allan , Nitzel, Greg , Hayes, Phillip Wayne , Schaeffer, Merrill Lynn
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/5258 , A61K2039/545 , A61K2039/552 , A61K2039/55516 , A61K2039/55555 , A61K2039/55566 , C12N7/00 , C12N2750/10022 , C12N2750/10023 , C12N2750/10034 , C12N2750/10051 , C12N2750/10071 , C12N2750/14143
摘要： The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.
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4.发明公开Use of a PCV2 immunogenic composition for lessening clinical symptoms in pigs 有权使用的免疫原性PCV2组合物的猪衰减系统疾病
公开(公告)号：EP2371382A1
公开(公告)日：2011-10-05
申请号：EP11164849.9
申请日：2006-12-28
发明人： Roof, Michael B. , Eichmeyer, Marc Allan , Nitzel, Greg , Hayes, Phillip Wayne , Schaeffer, Merrill Lynn
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/5258 , A61K2039/545 , A61K2039/552 , A61K2039/55516 , A61K2039/55555 , A61K2039/55566 , C12N7/00 , C12N2750/10022 , C12N2750/10023 , C12N2750/10034 , C12N2750/10051 , C12N2750/10071 , C12N2750/14143
摘要： The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.
摘要翻译： 本发明涉及使用免疫原性组合物的那样包括猪圆环病毒2型（PCV2）用于治疗几种临床表现（疾病）的抗原。 优选地，临床表现与PCV2感染相关。 优选地，它们包括淋巴结病，淋巴耗尽和/或多核/巨组织细胞。 更过去，临床症状包括与一种淋巴结肿大或以下症状中的猪的倍数：（1）间质性肺炎并小叶水肿，（2）皮肤苍白或黄疸，（3）斑驳萎缩性肝，（4）胃溃疡 （5）肾炎和（6）生殖病症，例如 流产，死产，木乃伊等。另外更多的临床症状包括皮娅样病变，通常已知的与胞内劳森菌感染有关。
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5.发明公开Multivalent PCV2 immunogenic compositions and methods of producing them 审中-公开多价PCV2免疫原性Zusammensetzungen und deren Vorbereitungsverfahren
公开(公告)号：EP2275132A2
公开(公告)日：2011-01-19
申请号：EP10174464.7
申请日：2006-12-28
发明人： Eichmeyer, Marc Allan , Hayes, Phillip Wayne , Nitzel, Greg , Roof, Michael B. , Schaeffer, Merrill Lynn
IPC分类号： A61K39/295 , A61K39/04 , A61K39/12 , C12N15/866
CPC分类号： A61K39/12 , A61K38/00 , A61K39/04 , A61K49/0004 , A61K2039/545 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C07K14/005 , C12N2750/10034 , C12N2750/14043 , C12N2770/10034
摘要： An improved method for recovering the protein expressed by open reading frame 2 from porcine circovirus type 2 is provided. Also provided is recombinant PCV2 ORF2 protein, and immunogenic compositions comprising PCV2 ORF2 protein. Moreover, multivalent combination vaccines are provided which include an immunological agent effective for reducing the incidence of or lessening the severity of PCV2 infection, preferably PCV2 ORF2 protein, or an immunogenic composition comprising PCV2 ORF2 protein, and at least one immunogenic active component of another disease-causing organism in swine,
摘要翻译： 提供了一种用于从猪圆环病毒2型中回收开放阅读框2表达的蛋白质的改进方法。 还提供重组PCV2 ORF2蛋白和包含PCV2 ORF2蛋白的免疫原性组合物。 此外，提供了多价组合疫苗，其包括有效降低PCV2感染（优选PCV2 ORF2蛋白）或包含PCV2 ORF2蛋白质的免疫原性组合物的发病率或降低PCV2 ORF2蛋白质的严重性的免疫学试剂，以及另一种疾病的至少一种免疫原性活性成分 在猪中有生物，
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公开(公告)号：EP2772266A1
公开(公告)日：2014-09-03
申请号：EP14164842.8
申请日：2012-03-12
IPC分类号： A61K39/125 , A61K39/145 , A61K39/245 , A61P11/00
CPC分类号： C12N7/00 , A61K2039/505 , A61K2039/5254 , C12N2770/32034 , C12N2770/32734
摘要： The disclosure provides for immunogenic compositions against Equine Rhinitis Virus, particularly Equine Rhinitis A and B Virus, and methods for their use and preparation. The immunogenic compositions, in alternate embodiments, also include other equine pathogens.
摘要翻译： 本公开提供了针对马鼻炎病毒，特别是马鼻炎A和B病毒的免疫原性组合物及其使用和制备方法。 在替代实施方案中，免疫原性组合物还包括其他马病原体。
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7.发明公开Use of a PCV2 immunogenic composition for lessening clinical symptoms in pigs 有权使用的免疫原性PCV2成分为猪疾病症状衰减
公开(公告)号：EP2371383A1
公开(公告)日：2011-10-05
申请号：EP11164850.7
申请日：2006-12-28
发明人： Roof, Michael B. , Eichmeyer, Marc Allan , Nitzel, Greg , Hayes, Phillip Wayne , Schaeffer, Merrill Lynn
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/5258 , A61K2039/545 , A61K2039/552 , A61K2039/55516 , A61K2039/55555 , A61K2039/55566 , C12N7/00 , C12N2750/10022 , C12N2750/10023 , C12N2750/10034 , C12N2750/10051 , C12N2750/10071 , C12N2750/14143
摘要： The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.
摘要翻译： 本发明涉及使用免疫原性组合物的那样包括猪圆环病毒2型（PCV2）用于治疗几种临床表现（疾病）的抗原。 优选地，临床表现与PCV2感染相关。 优选地，它们包括淋巴结病，淋巴耗尽和/或多核/巨组织细胞。 更过去，临床症状包括与一种淋巴结肿大或以下症状中的猪的倍数：（1）间质性肺炎并小叶水肿，（2）皮肤苍白或黄疸，（3）斑驳萎缩性肝，（4）胃溃疡 （5）肾炎和（6）生殖病症，例如 流产，死产，木乃伊等。另外更多的临床症状包括皮娅样病变，通常已知的与胞内劳森菌感染有关。
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8.发明公开
公开(公告)号：EP2275132A3
公开(公告)日：2011-04-20
申请号：EP10174464.7
申请日：2006-12-28
发明人： Eichmeyer, Marc Allan , Hayes, Phillip Wayne , Nitzel, Greg , Roof, Michael B. , Schaeffer, Merrill Lynn
IPC分类号： A61K39/295 , A61K39/04 , A61K39/12 , C12N15/866
CPC分类号： A61K39/12 , A61K38/00 , A61K39/04 , A61K49/0004 , A61K2039/545 , A61K2039/552 , A61K2039/55566 , A61K2039/70 , C07K14/005 , C12N2750/10034 , C12N2750/14043 , C12N2770/10034
摘要： An improved method for recovering the protein expressed by open reading frame 2 from porcine circovirus type 2 is provided. Also provided is recombinant PCV2 ORF2 protein, and immunogenic compositions comprising PCV2 ORF2 protein. Moreover, multivalent combination vaccines are provided which include an immunological agent effective for reducing the incidence of or lessening the severity of PCV2 infection, preferably PCV2 ORF2 protein, or an immunogenic composition comprising PCV2 ORF2 protein, and at least one immunogenic active component of another disease-causing organism in swine,
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公开(公告)号：EP2275130A3
公开(公告)日：2011-03-23
申请号：EP10174456.3
申请日：2006-12-28
发明人： Roof, Michael B. , Eichmeyer, Marc Allan , Nitzel, Greg , Hayes, Phillip Wayne , Schaeffer, Merrill Lynn
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/5258 , A61K2039/545 , A61K2039/552 , A61K2039/55516 , A61K2039/55555 , A61K2039/55566 , C12N7/00 , C12N2750/10022 , C12N2750/10023 , C12N2750/10034 , C12N2750/10051 , C12N2750/10071 , C12N2750/14143
摘要： The present invention relates to an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.
摘要翻译： 本发明涉及包含用于治疗几种临床表现（疾病）的猪圆环病毒2型（PCV2）抗原的免疫原性组合物。 优选地，临床表现与PCV2感染相关。 优选地，它们包括淋巴结病，淋巴细胞减少和/或多核/巨细胞组织细胞。 此外，临床症状包括与猪中的一种或多种以下症状相结合的淋巴结病：（1）间质性肺炎与小叶间水肿，（2）皮肤苍白或黄疸，（3）斑驳萎缩性肝脏，（4）胃溃疡 ，（5）肾炎和（6）生殖障碍，例如 流产，死胎，木乃伊等。此外，临床症状包括Pia样病变，通常已知与细胞内劳森氏菌感染有关。
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10.发明授权Use of a PCV2 immunogenic composition for lessening clinical symptoms in pigs 有权使用的免疫原性PCV2组合物的猪衰减系统疾病
公开(公告)号：EP2371382B1
公开(公告)日：2016-03-02
申请号：EP11164849.9
申请日：2006-12-28
发明人： Roof, Michael B. , Eichmeyer, Marc Allan , Nitzel, Greg , Hayes, Phillip Wayne , Schaeffer, Merrill Lynn
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/5258 , A61K2039/545 , A61K2039/552 , A61K2039/55516 , A61K2039/55555 , A61K2039/55566 , C12N7/00 , C12N2750/10022 , C12N2750/10023 , C12N2750/10034 , C12N2750/10051 , C12N2750/10071 , C12N2750/14143
摘要： The present invention relates to an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.
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