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    PCV2 ORF2 immunogenic composition
    1.
    发明公开
    PCV2 ORF2 immunogenic composition 审中-公开
    PCV2ORF2免疫原性组合物

    公开(公告)号：EP2275130A2

    公开(公告)日：2011-01-19

    申请号：EP10174456.3

    申请日：2006-12-28

    申请人： BOEHRINGER INGELHEIM VETMEDICA, INC.

    发明人： Roof, Michael B. ,  Eichmeyer, Marc Allan ,  Nitzel, Greg ,  Hayes, Phillip Wayne ,  Schaeffer, Merrill Lynn

    IPC分类号： A61K39/12

    CPC分类号： A61K39/12 ,  A61K2039/5252 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/55566 ,  C12N7/00 ,  C12N2750/10022 ,  C12N2750/10023 ,  C12N2750/10034 ,  C12N2750/10051 ,  C12N2750/10071 ,  C12N2750/14143

    摘要： The present invention relates to an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.

    摘要翻译： 本发明涉及包含用于治疗几种临床表现（疾病）的2型猪圆环病毒（PCV2）抗原的免疫原性组合物。 优选地，临床表现与PCV2感染有关。 优选地，它们包括淋巴结病，淋巴耗竭和/或多核/巨组织细胞。 此外，临床症状包括淋巴结病和猪中的一种或多种以下症状：（1）伴有小叶间水肿的间质性肺炎，（2）皮肤苍白或黄疸，（3）斑驳萎缩肝，（4）胃溃疡 ，（5）肾炎和（6）生殖障碍，例如 流产，死胎，木乃伊等。此外，临床症状包括Pia类病变，通常已知其与细胞内劳索尼亚菌感染相关。

    PCV2 ORF2 immunogenic composition
    9.
    发明公开
    PCV2 ORF2 immunogenic composition 审中-公开
    PCV2 ORF2 immunogenische Zusammensetzung

    公开(公告)号：EP2275130A3

    公开(公告)日：2011-03-23

    申请号：EP10174456.3

    申请日：2006-12-28

    申请人： BOEHRINGER INGELHEIM VETMEDICA, INC.

    发明人： Roof, Michael B. ,  Eichmeyer, Marc Allan ,  Nitzel, Greg ,  Hayes, Phillip Wayne ,  Schaeffer, Merrill Lynn

    IPC分类号： A61K39/12

    CPC分类号： A61K39/12 ,  A61K2039/5252 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/55566 ,  C12N7/00 ,  C12N2750/10022 ,  C12N2750/10023 ,  C12N2750/10034 ,  C12N2750/10051 ,  C12N2750/10071 ,  C12N2750/14143

    摘要： The present invention relates to an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.

    摘要翻译： 本发明涉及包含用于治疗几种临床表现（疾病）的猪圆环病毒2型（PCV2）抗原的免疫原性组合物。 优选地，临床表现与PCV2感染相关。 优选地，它们包括淋巴结病，淋巴细胞减少和/或多核/巨细胞组织细胞。 此外，临床症状包括与猪中的一种或多种以下症状相结合的淋巴结病：（1）间质性肺炎与小叶间水肿，（2）皮肤苍白或黄疸，（3）斑驳萎缩性肝脏，（4）胃溃疡 ，（5）肾炎和（6）生殖障碍，例如 流产，死胎，木乃伊等。此外，临床症状包括Pia样病变，通常已知与细胞内劳森氏菌感染有关。

    PCV2 immunogenic compositions and methods of producing such compositions
    10.
    发明公开
    PCV2 immunogenic compositions and methods of producing such compositions 有权
    用于在方法中使用用于预防PCV2感染PCV2免疫原性组合物

    公开(公告)号：EP2281829A2

    公开(公告)日：2011-02-09

    申请号：EP10174465.4

    申请日：2005-12-29

    申请人： BOEHRINGER INGELHEIM VETMEDICA, INC.

    发明人： Eichmeyer, Marc Allan ,  Schaeffer, Merrill Lynn ,  Nitzel, Greg

    IPC分类号： C07K14/01 ,  A61K39/12

    CPC分类号： A61K39/12 ,  A61K33/00 ,  A61K45/06 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55555 ,  C07K14/005 ,  C12N2710/14143 ,  C12N2710/14163 ,  C12N2750/10022 ,  C12N2750/10034 ,  C12N2750/10051 ,  C12N2770/10034

    摘要： An improved method for recovering the protein expressed by open reading frame 2 from porcine circovirus type 2 is provided. The method generally involves the steps of transfecting recombinant virus containing open reading frame 2 coding sequences into cells contained in growth media, causing the virus to express open reading frame 2, and recovering the expressed protein in the supernate. This recovery should take place beginning approximately 5 days after infection of the cells in order to permit sufficient quantities of recombinant protein to be expressed and secreted from the cell into the growth media. Such methods avoid costly and time consuming extraction procedures required to separate and recover the recombinant protein from within the cells.

    摘要翻译： 提供了一种用于回收由开放阅读框2从2型猪圆环过表达的蛋白质的改进方法。 该方法基因反弹涉及到转染的重组病毒含有开放阅读框2的编码序列到包含在生长培养基中的细胞，从而导致病毒表达的开放阅读框架2，并回收在所述上清液中过量表达的蛋白质的步骤。 此恢复shoulderstand发生开始感染细胞后约5天以允许重组蛋白的量足以中过表达，并从细胞到生长培养基中分泌。 搜索方法避免分离和从细胞内恢复所述重组蛋白需要昂贵和费时的提取程序。