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1.发明公开Phenyl or phenylalkyl substituted naphtalene derivatives having retinoid-like activity as well as anti-tumor activities 失效苯基苯基烷基取代基Naphthalenderivate mitRetinoidähnlicherAktivitätund Antitumor Wirkungen。
公开(公告)号：EP0661261A1
公开(公告)日：1995-07-05
申请号：EP95100032.2
申请日：1995-01-02
IPC分类号： C07C235/84 , C07C233/81 , C07C69/76 , C07C63/66 , C07C63/33 , C07C327/48 , A61K31/165 , A61K31/19
CPC分类号： C07C63/72 , C07C63/331 , C07C69/76 , C07C233/81 , C07C235/66 , C07C327/48
摘要： This invention relates to a retinoid compound of formula I
in which
Y is -CO-NH-, -CR²=CR³-, -CO-O-, -O-CO-, -C(=S)-NH-, -C≡C-, -O-CH₂-, -CH₂-O-, or -CH₂-CH₂-;
A is -(CH₂) t - or a bond;
Q is phenyl optionally substituted with one to three same or different C₁₋₆alkyl, C₁₋₆alkoxy, halogen, or -CO₂R⁴;
R¹ is -CO₂Z, -CONHR⁵, C₁₋₆alkyl, -CH₂OH, or -CHO;
R², R³, R⁴, R⁵, and Z are independently hydrogen or C₁₋₆alkyl;
t is one to six.摘要翻译： 本发明涉及其中Y是-CO-NH-，-CR 2 = CR 3 - ， - CO-O-，-O-CO-，-C（ = S）-NH-，-C元素C，-O-CH 2 - ， - CH 2 -O-或-CH 2 -CH 2 - ; A是 - （CH 2）t - 或键; Q是任选被一至三个相同或不同的C 1-6烷基，C 1-6烷氧基，卤素或-CO 2 R 4取代的苯基; R 1是-CO 2 Z，-CONHR 5，C 1-6烷基，-CH 2 OH或-CHO; R 2，R 3，R 4，R 5和Z独立地是氢或C 1-6烷基; t是一到六。
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2.发明授权Phenyl or phenylalkyl substituted naphtalene derivatives having retinoid-like activity as well as anti-tumor activities 失效苯基或苯基 - 取代的萘衍生物与类视黄醇样活性和抗肿瘤作用
公开(公告)号：EP0661261B1
公开(公告)日：1997-05-07
申请号：EP95100032.2
申请日：1995-01-02
IPC分类号： C07C235/84 , C07C233/81 , C07C69/76 , C07C63/66 , C07C63/33 , C07C327/48 , A61K31/165 , A61K31/19
CPC分类号： C07C63/72 , C07C63/331 , C07C69/76 , C07C233/81 , C07C235/66 , C07C327/48
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