利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

9 条记录 (耗时 0.018 秒)

    Deoxy taxols
    1.
    发明公开
    Deoxy taxols 失效
    脱氧紫杉醇酯衍生物。

    公开(公告)号：EP0590267A2

    公开(公告)日：1994-04-06

    申请号：EP93112247.7

    申请日：1993-07-30

    申请人： Bristol-Myers Squibb Company

    发明人： Farina, Vittorio ,  Chen, Shu-Hui ,  Langley, David R. ,  Wittman, Mark D. ,  Kant, Joydeep ,  Vyas, Dolatrai

    IPC分类号： C07D305/14 ,  C07F7/18 ,  A61K31/335 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12

    CPC分类号： C07D407/12 ,  C07C233/82 ,  C07C271/22 ,  C07D305/14 ,  C07D409/12 ,  C07D413/12 ,  C07F7/1856 ,  C07F9/65512 ,  C07F9/65586 ,  H01L21/4839

    摘要： in which

    R¹ is -COR z in which R z is RO- or R;
    R g is C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, or a radical of the formula -W-R x in which W is a bond, C₂₋₆ alkenediyl, or -(CH₂) t -, in which t is one to six; and R x is naphthyl, phenyl, or heteroaryl, and furthermore R x can be optionally substituted with one to three same or different C₁₋₆ alkyl, C₁₋₆ alkoxy, halogen or -CF₃ groups;
    R² is -OCOR, H, OH, -OR, -OSO₂R, -OCONR o R, -OCONHR, -OCOO(CH₂) t R, or -OCOOR; and
    R and R o are independently C₁₋₆ alkyl, C₂₋₆ alkenyl, C₃₋₆ cycloalkyl, C₂₋₆ alkynyl, or phenyl, optionally substituted with one to three same or different C₁₋₆ alkyl, C₁₋₆ alkoxy, halogen or -CF₃ groups.

    Further provided by this invention are pharmaceutical formulations and intermediates for the the preparation of deoxy taxols of formula I. A method of treating mammalian tumors using a compound of formula I is also provided.

    摘要翻译： 其中R 1为-COR z，其中R z为RO-或R; R g是C 1-6烷基，C 2-6烯基，C 2-6炔基，C 3-6环烷基或其中W是键的式-WR x基团，C 2-6亚烯基或 - （CH 2）t - ，其中t为1至6; 并且R x是萘基，苯基或杂芳基，此外R x可以任选地被一至三个相同或不同的C 1-6烷基，C 1-6烷氧基，卤素或-CF 3基团取代; R 2是-OCOR，H，OH，-OR，-OSO 2 R，-OCONR o，-OCONHR，-OCOO（CH 2）t R或-OCOOR; 并且R和R o独立地为C 1-6烷基，C 2-6烯基，C 3-6环烷基，C 2-6炔基或苯基，任选地被一至三个相同或不同的C 1-6烷基，C 1-6烷氧基 ，卤素或-CF 3基团。 本发明进一步提供了用于制备式I的脱氧紫杉醇的药物制剂和中间体。还提供了使用式I化合物治疗哺乳动物肿瘤的方法。

    Fluoro taxols with antitumor activity
    4.
    发明公开
    Fluoro taxols with antitumor activity 失效
    氟紫杉醇抗肿瘤剂Wirkung。

    公开(公告)号：EP0577082A1

    公开(公告)日：1994-01-05

    申请号：EP93110374.1

    申请日：1993-06-29

    申请人： Bristol-Myers Squibb Company

    发明人： Chen, Shu-Hui ,  Farina, Vittorio ,  Vyas, Dolatrai ,  Kant, Joydeep

    IPC分类号： A61K31/335 ,  C07D305/14

    CPC分类号： H05K1/16 ,  C07C233/82 ,  C07C271/22 ,  C07D305/14 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07F7/1856 ,  C07F9/65512 ,  C07F9/65586 ,  H01L21/4839 ,  H05K1/0306 ,  H05K1/092 ,  H05K3/403

    摘要： This invention relates to a fluorinated taxol of formula I

    in which

    R¹ is -COR z in which R z is RO- or R;
    R g is C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, or a radical of the formula -W-R x in which W is a bond, C₂₋₆ alkenediyl, or -(CH₂) t -, in which t is one to six; and R x is naphthyl, furyl, thienyl or phenyl, and furthermore R x can be optionally substituted with one to three same or different C₁₋₆ alkyl, C₁₋₆ alkoxy, halogen or -CF₃ groups;
    R² is -OCOR, H, OH, -OR, -OSO₂R, -OCONR o R, -OCONHR, -OCOO(CH₂) t R, or -OCOOR; and
    R and R o are independently C₁₋₆ alkyl, C₂₋₆ alkenyl, C₃₋₆ cycloalkyl, C₂₋₆ alkynyl, or phenyl, optionally substituted with one to three same or different C₁₋₆ alkyl, C₁₋₆ alkoxy, halogen or -CF₃ groups.
    Further provided by this invention are pharmaceutical formulations and useful intermediates for the fluorinated taxols of formula I. A method of treating mammalian tumors using a compound of formula I is also provided.

    摘要翻译： 本发明涉及式Ⅰ的氟化紫杉醇，其中R 1为-COR z，其中R z为RO-或R; R g是C 1-6烷基，C 2-6烯基，C 2-6炔基，C 3-6环烷基或其中W是键的式-WR x基团，C 2-6亚烯基或 - （CH 2）t - ，其中t为1至6; 并且R x是萘基，呋喃基，噻吩基或苯基，此外R x可以任选地被一至三个相同或不同的C 1-6烷基，C 1-6烷氧基，卤素或-CF 3基团取代; R 2是-OCOR，H，OH，-OR，-OSO 2 R，-OCONR o，-OCONHR，-OCOO（CH 2）t R或-OCOOR; 并且R和R o独立地为C 1-6烷基，C 2-6烯基，C 3-6环烷基，C 2-6炔基或苯基，任选地被一至三个相同或不同的C 1-6烷基，C 1-6烷氧基 ，卤素或-CF 3基团。 本发明进一步提供了用于式I的氟化的紫杉醇的药物制剂和有用的中间体。还提供了使用式I化合物治疗哺乳动物肿瘤的方法。

    Deoxy taxols
    9.
    发明公开
    Deoxy taxols 失效
    脱氧紫杉醇

    公开(公告)号：EP0590267A3

    公开(公告)日：1994-05-18

    申请号：EP93112247.7

    申请日：1993-07-30

    申请人： Bristol-Myers Squibb Company

    发明人： Farina, Vittorio ,  Chen, Shu-Hui ,  Langley, David R. ,  Wittman, Mark D. ,  Kant, Joydeep ,  Vyas, Dolatrai

    IPC分类号： C07D305/14 ,  C07F7/18 ,  A61K31/335 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12

    CPC分类号： C07D407/12 ,  C07C233/82 ,  C07C271/22 ,  C07D305/14 ,  C07D409/12 ,  C07D413/12 ,  C07F7/1856 ,  C07F9/65512 ,  C07F9/65586 ,  H01L21/4839

    摘要： in which
    R¹ is -COR z in which R z is RO- or R; R g is C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, or a radical of the formula -W-R x in which W is a bond, C₂₋₆ alkenediyl, or -(CH₂) t -, in which t is one to six; and R x is naphthyl, phenyl, or heteroaryl, and furthermore R x can be optionally substituted with one to three same or different C₁₋₆ alkyl, C₁₋₆ alkoxy, halogen or -CF₃ groups; R² is -OCOR, H, OH, -OR, -OSO₂R, -OCONR o R, -OCONHR, -OCOO(CH₂) t R, or -OCOOR; and R and R o are independently C₁₋₆ alkyl, C₂₋₆ alkenyl, C₃₋₆ cycloalkyl, C₂₋₆ alkynyl, or phenyl, optionally substituted with one to three same or different C₁₋₆ alkyl, C₁₋₆ alkoxy, halogen or -CF₃ groups. Further provided by this invention are pharmaceutical formulations and intermediates for the the preparation of deoxy taxols of formula I. A method of treating mammalian tumors using a compound of formula I is also provided.

    摘要翻译： 其中R 1是-CORz，其中Rz是RO-或R; Rg是C 1-6烷基，C 2-6链烯基，C 2-6炔基，C 3-6环烷基或式-W-Rx的基团，其中W是键，C 2-6链烯二基或 - （CH 2）t - ，其中t是1到6; Rx是萘基，苯基或杂芳基，而且Rx可以任选被1-3个相同或不同的C1-6烷基，C1-6烷氧基，卤素或-CF3基团取代; R 2是-OCOR，H，OH，-OR，-OSO 2 R，-OCONR 0R，-OCONHR，-OCOO（CH 2）t R或-OCOOR; R 1和R 2独立地为C 1-6烷基，C 2-6链烯基，C 3-6环烷基，C 2-6炔基或苯基，它们任选被1-3个相同或不同的C 1-6烷基，C 1-6烷氧基，卤素或 -CF 3基团。 本发明进一步提供了用于制备式I的脱氧紫杉醇的药物制剂和中间体。还提供了使用式I化合物治疗哺乳动物肿瘤的方法。