摘要:
The present invention concerns novel water-soluble phosphonooxymethyl ethers of taxane derivatives, their use as antitumor agents, and pharmaceutical compositions containing the novel compounds.
摘要:
Solutions of carboplatin and other malonato platinum(II) antitumor agents are prepared containing stabilizing amounts of 1,1-cyclobutanedicarboxylic acid or salt at pH 4-8. The stabilizers inhibit unacceptable discoloration and precipitation. The solutions may also be stabilized by purging the carrier with air or oxygen and, optionally, blanketing the headspace with air or oxygen.
摘要:
Disclosed herein are stable, ready-to-use cisplatin aqueous solutions containing high concentrations of chloride ion. Solutions of this invention contain less aquated platinum species and are closer to physiological pH than known cisplatin solutions. Also included are lyophilized cisplatin compositions having high chloride concentrations.
摘要:
The present invention concerns a new pseudopolymorph of paclitaxel, a pharmaceutical composition thereof, and its use as an antitumor agent. Another aspect relates to preparation of this pseudopolymorph.
摘要:
A new antitumor antibiotic designated BMY-40800 is produced by fermentation of Streptomyces hygroscopicus ATCC 53653. The new compound inhibits the growth of tumors in experimental animals.
摘要:
A stable, amorphous, lyophilized dihydrochloride salt of 7-(α-(2-aminothiazol-4-yl)-α-(Z)-methoxyiminoacetamido]-3-[(1-methyl-1-pyrrolidinium)methyl]-3-cephem-4-carboxylate is described. This lyophilized salt is more easily prepared than the crystalline counterpart and can be reconstituted in effective concentrations for intramuscular and intravenous injection utilizing suitable organic and inorganic bases to pH 3-7.0.