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1.COMPOUNDS AND METHODS FOR THE TREATMENT OF ISOCITRATE DEHYDROGNASE RELATED DISEASES 审中-公开
标题翻译: 化合物和方法治疗由异柠檬酸介导的疾病公开(公告)号:EP2691391A4
公开(公告)日:2014-09-10
申请号:EP12800687
申请日:2012-03-29
申请人: BROAD INST INC , HARVARD COLLEGE
发明人: HUSSAIN MAHMUD , ITO DAISUKE , LAW JASON , LEIENDECKER MATTHIAS , LIU KE , MUNOZ BENITO , SCHREIBER STUART , SHAMJI ALYKHAN , STERN ANDREW
IPC分类号: C07D419/12 , A61K31/553 , A61K31/554 , A61P35/00 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D498/04
CPC分类号: C07D419/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D498/04
摘要: The invention relates to compounds of Formula I or a pharmaceutically acceptable salt, ester or prodrug thereof:
摘要翻译: 本发明涉及式I或其药学上可接受的盐,酯或前药的化合物:
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公开(公告)号:EP0785992A4
公开(公告)日:1999-12-22
申请号:EP95937629
申请日:1995-10-25
IPC分类号: C12N15/00 , C07K14/47 , C07K14/705 , C07K14/715 , C07K19/00 , C12N5/10 , C12N15/62 , C12R1/91 , C12N15/12
CPC分类号: C07K14/715 , C07K14/4705 , C07K2319/00 , C07K2319/03 , C07K2319/42 , C07K2319/715 , C07K2319/72 , C12N15/62
摘要: This invention concerns materials, methods and applications relating to the multimerizing of chimeric proteins with a dimeric or multimeric, preferably non-peptidic, ligand. Aspects of the invention are exemplified by ligand-mediated transformation of stem cells permitting stem cell growth in a growth-factor independent manner.
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