公开(公告)号：EP0585368A1

公开(公告)日：1994-03-09

申请号：EP92912606.0

申请日：1992-04-22

申请人： BROWN UNIVERSITY RESEARCH FOUNDATION

发明人： DIONNE, Keith, E. ,  EMERICH, Dwaine, F. ,  HOFFMAN, Diane ,  SCHARP, David, W. ,  LACY, Paul, E. ,  AEBISCHER, Patrick ,  SANBERG, Paul, R. ,  CHRISTENSON, Lisa ,  HEGRE, Orion, D. ,  VASCONCELLOS, Alfred, V. ,  LYSAGHT, Michael, J. ,  GENTILE, Frank, T.

IPC分类号： A61F2 ,  A61K9 ,  A61K35 ,  A61K38 ,  A61K39 ,  A61K47 ,  A61K48 ,  A61L27 ,  C12N5

CPC分类号： A61K9/0092 ,  A61K9/0024 ,  A61K9/4816 ,  A61K35/12 ,  A61K35/30 ,  A61K35/39 ,  A61K38/185 ,  A61K48/00 ,  A61K2035/126 ,  A61K2035/128 ,  C12N5/0012 ,  C12N5/0062 ,  C12N5/0614 ,  C12N5/0656 ,  C12N5/0677 ,  C12N2510/02 ,  Y10S514/814 ,  Y10S514/866

摘要： An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region containing isolated cells and materials sufficient to maintain the cells, and a permselective, biocompatible, peripheral region free of the isolated cells, which immunoisolates the core yet provides for the delivery of the secreted product or metabolic function to the individual. The vehicle is particularly well-suited to delivery of insulin from immunoisolated islets of Langerhans, and can also be used advantageously for delivery of high molecular weight products, such as products larger than IgG. A method of making a biocompatible, immunoisolatory implantable vehicle, consisting in a first embodiment of a coextrusion process, and in a second embodiment of a stepwise process. A method for isolating cells within a biocompatible, immunoisolatory implantable vehicle, which protects the isolated cells from attack by the immune system of an individual in whom the vehicle is implanted. A method of providing a needed biological product or metabolic function to an individual, comprising implanting into the individual an immunoisolatory vehicle containing isolated cells which produce the product or provide the metabolic function.

公开(公告)号：EP0585368B1

公开(公告)日：1997-08-06

申请号：EP92912606.8

申请日：1992-04-22

申请人： BROWN UNIVERSITY RESEARCH FOUNDATION

发明人： DIONNE, Keith, E. ,  EMERICH, Dwaine, F. ,  HOFFMAN, Diane ,  SCHARP, David, W. ,  LACY, Paul, E. ,  AEBISCHER, Patrick ,  SANBERG, Paul, R. ,  CHRISTENSON, Lisa ,  HEGRE, Orion, D. ,  VASCONCELLOS, Alfred, V. ,  LYSAGHT, Michael, J. ,  GENTILE, Frank, T.

IPC分类号： A61F13/00

CPC分类号： A61K9/0092 ,  A61K9/0024 ,  A61K9/4816 ,  A61K35/12 ,  A61K35/30 ,  A61K35/39 ,  A61K38/185 ,  A61K48/00 ,  A61K2035/126 ,  A61K2035/128 ,  C12N5/0012 ,  C12N5/0062 ,  C12N5/0614 ,  C12N5/0656 ,  C12N5/0677 ,  C12N2510/02 ,  Y10S514/814 ,  Y10S514/866

摘要： An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region containing isolated cells and materials sufficient to maintain the cells, and a permselective, biocompatible, peripheral region free of the isolated cells, which immunoisolates the core yet provides for the delivery of the secreted product or metabolic function to the individual. The vehicle is particularly well-suited to delivery of insulin from immunoisolated islets of Langerhans, and can also be used advantageously for delivery of high molecular weight products, such as products larger than IgG. A method of making a biocompatible, immunoisolatory implantable vehicle, consisting in a first embodiment of a coextrusion process, and in a second embodiment of a stepwise process. A method for isolating cells within a biocompatible, immunoisolatory implantable vehicle, which protects the isolated cells from attack by the immune system of an individual in whom the vehicle is implanted. A method of providing a needed biological product or metabolic function to an individual, comprising implanting into the individual an immunoisolatory vehicle containing isolated cells which produce the product or provide the metabolic function.

公开(公告)号：EP0550719B1

公开(公告)日：1997-03-05

申请号：EP92915009.2

申请日：1992-06-25

申请人： BROWN UNIVERSITY RESEARCH FOUNDATION

发明人： AEBISCHER, Patrick ,  GODDARD, Moses ,  MOLDAUER, John, G. ,  MULHAUSER, Paul, J. ,  RATHBUN, M., Anne ,  SANBERG, Paul, R. ,  VASCONCELLOS, Alfred, V.

IPC分类号： A61M31/00 ,  A61M37/00

CPC分类号： A61K9/0085 ,  A61F2/022 ,  A61M31/002

摘要： Implantable therapy systems are disclosed for the local and controlled delivery of a biologically active factor to the brain, spinal cord and other target regions of a subject suffering from a dibilatating condition. The method of the invention involves surgically exposing an insertion site, generally located above a predetermined treatment site (12), in a patient. A cannula (20), having an obturator (30) positioned therein, is inserted at the insertion site, defining a pathway to the treatment site. The cannula (20) is preferably a low friction polymeric material such as polytetrafluoroethylene. The cannula (20) generally has an open proximal end for receiving the obturator (30), and an open distal end, preferably a tapered end, for delivery of neurologically active factors to the treatment site (12). The obturator (30) is then removed from the cannula (20), and a biocompatible tethered vehicle (40) containing a biologically active material is inserted into the cannula along the passageway. A guide wire (32) can be inserted within the cannula, behind the vehicle (40), to position the proximal end of the vehicle at the proximal tip of the cannula (20b). Once the vehicle (40) is positioned near the proximal end of the cannula (20), the cannula is removed from the passageway, followed by the guide wire (32), leaving the vehicle (40) positioned at the treatment site (12).

摘要翻译： 公开了可植入治疗系统用于局部和受控地将生物活性因子递送至患有二拉丁化病症的受试者的大脑，脊髓和其他目标区域。 本发明的方法涉及通常位于预定治疗部位（12）上方的插入部位手术暴露于患者体内。 其中定位有插塞（30）的插管（20）插入插入部位，限定通向治疗部位的通路。 套管（20）优选为低摩擦聚合材料，例如聚四氟乙烯。 套管20通常具有用于接收闭塞器30的开口近端和用于将神经活性因子递送至治疗部位12的开放远端，优选锥形端。 然后从插管（20）中取出阻塞器（30），并且沿着通路将含有生物活性物质的生物相容性系留车辆（40）插入插管中。 导丝（32）可插入插管内，在车辆（40）后方，以将车辆的近端定位在套管（20b）的近端尖端处。 一旦车辆（40）定位在套管（20）的近端附近，将套管从通路移除，接着导丝（32）移出，使得车辆（40）位于治疗部位（12）处， 。

公开(公告)号：EP0550719A1

公开(公告)日：1993-07-14

申请号：EP92915009.0

申请日：1992-06-25

申请人： BROWN UNIVERSITY RESEARCH FOUNDATION

发明人： AEBISCHER, Patrick ,  GODDARD, Moses ,  MOLDAUER, John, G. ,  MULHAUSER, Paul, J. ,  RATHBUN, M., Anne ,  SANBERG, Paul, R. ,  VASCONCELLOS, Alfred, V.

IPC分类号： A61M37 ,  A61F2 ,  A61K9 ,  A61M31

CPC分类号： A61K9/0085 ,  A61F2/022 ,  A61M31/002

摘要： Systèmes thérapeutiques implantables pour l'administration locale et régulée d'un facteur biologiquement actif au cerveau, à la moëlle épinière et à d'autres régions cibles d'un sujet souffrant d'une infection débilitante. La méthode consiste à exposer chirurgicalement un site d'insertion, situé généralement au-dessus d'un site de traitement prédéterminé (12), chez un patient. Une canule (20), dans laquelle est placé un obturateur (30) est insérée au niveau du site d'insertion, constituant ainsi un trajet vers le site de traitement. La canule (20) est constituée de préférence d'un matériau polymère à basse friction, tel que le polytétrafluoréthylène. La canule (20) présente généralement une extrémité proximale ouverte pour la réception de l'obturateur (30), et une extrémité distale ouverte destinée à la délivrance des facteurs neurologiquement actifs sur le site de traitement (12). L'obturateur (30) est ensuite retiré de la canule (20), un véhicule biocompatible (40) retenu par une attache (40) et contenant un matériau biologiquement actif est inséré dans la canule le long du trajet. Un fil de guidage (30) peut être inséré dans la canule, derrière le véhicule (40) pour placer l'extrémité proximale du véhicule à l'extrémité proximale de la canule (20b). Une fois que le véhicule (40) est placé près de l'extrémité proximale de la canule (20), on retire tout d'abord la canule, puis le fil de guidage (32), en laissant en place le véhicule (40) sur le site de traitement (12).

摘要翻译： 可植入的治疗系统用于局部和受控地将生物活性因子递送至患有衰弱感染的受试者的大脑，脊髓和其他目标区域。 该方法涉及手术地暴露插入位点，该插入位置通常位于预定治疗部位（12）上方的患者体内。 其中放置有挡板（30）的套管（20）插入插入部位，由此提供通向治疗部位的路径。 套管（20）优选由低摩擦聚合物材料如聚四氟乙烯制成。 套管（20）通常具有用于接收闭塞器（30）的开放近端和用于将神经活性因子递送至治疗部位（12）的开放远端。 然后从插管（20）中取出闭塞器（30），将由紧固件（40）保持并包含生物活性物质的生物相容性媒介物（40）沿着该路径插入到插管中。 导丝（30）可以插入到车辆（40）后面的套管中，以将车辆的近端定位在套管（20b）的近端处。 一旦车辆（40）放置在套管（20）的近端附近，首先移除套管然后导丝（32），将车辆（40）留在原位。 在治疗部位（12）。